Marco A. coelho
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marcoacoelho.bsky.social
Marco A. coelho
@marcoacoelho.bsky.social
30 followers 23 following 1 posts
Fungal Genomics & Evolution | Mating-type loci | Exploring the origins of Cryptococcus pathogens | Chromosome evolution
Assistant Research Professor @ Duke University
scholars.duke.edu/person/marco.dias.coelho
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Marco A. coelho @marcoacoelho.bsky.social · Feb 17
🚨 New preprint alert! 🚨
Excited to share our latest study on mating-type locus evolution in *Cryptococcus* and closely related species! 🧬🔬

Check it out on bioRxiv: 🔗 www.biorxiv.org/content/10.1...

Feedback and discussions welcome! #FungalGenomics #Cryptococcus #Evolution #MATlocus
Reposted by Marco A. coelho
plosbiology.org
Evolution of fungal mating systems: Study of #Cryptococcus & Kwoniella by @marcoacoelho.bsky.social @marciadavidpalma.bsky.social &co shows that MAT locus fusions & recombination suppression drive diversity of #SexualReproduction in #fungi @plosbiology.org 🧪 plos.io/479579M
Top: Micrographs showing hyphal filaments extending from colony peripheries in a sexual cross between CBS8507 and CBS10435 after 2 weeks of incubation on CMA and V8 pH 5 media, in the dark, at room temperature. Insets depict two types of basidia: globose (a–c) and lageniform (b–d). Black arrows indicate clusters of cells emerging near basidia (either at the surface or embedded), scored as potential meiotic progeny (basidiospores). Bottom: Schematic representation of key chromosomal rearrangements and evolutionary events underlying transitions from tetrapolar to bipolar and pseudobipolar mating configurations. The phylogenetic tree highlights inferred changes in MAT locus structure, with color-coded branches representing both extant and reconstructed MAT configurations. Dashed lines indicate unresolved phylogenetic relationships among clades A, B, and C. Insets summarize distinct evolutionary stages, including: the ancestral organization with unlinked and compact P/R and HD loci (1); small-scale expansion of the P/R locus in Kwoniella (2); two independent large-scale expansions of the P/R locus in Cryptococcus (5); relocation of P/R and HD loci onto the same chromosome in Kwoniella resulting in either pseudobipolar (3) or fused (4) MAT configurations; and independent HD-P/R fusion events with HD gene loss in Cryptococcus pathogens and Cryptococcus sp. 3 (6). These transitions illustrate the diverse pathways by which chromosomal rearrangements (CRs) have shaped MAT locus architecture in these fungal lineages.
October 6, 2025 at 7:59 AM
Reposted by Marco A. coelho
asiya-gusa.bsky.social
SCIENCE MAKES AMERICA GREAT!!! 🧬 🧫 👩🏾‍🔬 #standupforscience2025
March 7, 2025 at 6:58 PM
Reposted by Marco A. coelho
biorxivpreprint.bsky.social
Tracing the evolution and genomic dynamics of mating-type loci in Cryptococcus pathogens and closely related species https://www.biorxiv.org/content/10.1101/2025.02.12.637874v1
February 17, 2025 at 1:33 AM
marcoacoelho.bsky.social
🚨 New preprint alert! 🚨
Excited to share our latest study on mating-type locus evolution in *Cryptococcus* and closely related species! 🧬🔬

Check it out on bioRxiv: 🔗 www.biorxiv.org/content/10.1...

Feedback and discussions welcome! #FungalGenomics #Cryptococcus #Evolution #MATlocus
February 17, 2025 at 9:12 PM
Reposted by Marco A. coelho
marciadavidpalma.bsky.social
🚀New review in Nature from Nicola Case @CowenLab: www.nature.com/articles/s41...
February 5, 2025 at 4:40 PM
Reposted by Marco A. coelho
marciadavidpalma.bsky.social
Our latest Pearl, "Decoding Cryptococcus: From African biodiversity to worldwide prevalence," is now in PLOS Pathogens! We reflect on how biogeography, genetic diversity, and ecological factors shape global distribution, with a special focus on African biodiversity. journals.plos.org/plospathogen...
Decoding Cryptococcus: From African biodiversity to worldwide prevalence
journals.plos.org
February 3, 2025 at 9:47 PM