@maraaspinall.bsky.social
ALSO IN THIS ISSUE
#GAO report recommends coordinated national testing strategy
More evidence for #p-tau217 as #Alzheimer’s #biomarker
Do home medical tests really “miss the mark”?
#sensitiveandspecific #diagnostics #wearabledevice #infectiousdisease #pandemicpreparedness #hometesting
#GAO report recommends coordinated national testing strategy
More evidence for #p-tau217 as #Alzheimer’s #biomarker
Do home medical tests really “miss the mark”?
#sensitiveandspecific #diagnostics #wearabledevice #infectiousdisease #pandemicpreparedness #hometesting
A windfall of wearables
Volume 12, Issue 6 | July 17, 2025
open.substack.com
July 18, 2025 at 12:48 AM
ALSO IN THIS ISSUE
#GAO report recommends coordinated national testing strategy
More evidence for #p-tau217 as #Alzheimer’s #biomarker
Do home medical tests really “miss the mark”?
#sensitiveandspecific #diagnostics #wearabledevice #infectiousdisease #pandemicpreparedness #hometesting
#GAO report recommends coordinated national testing strategy
More evidence for #p-tau217 as #Alzheimer’s #biomarker
Do home medical tests really “miss the mark”?
#sensitiveandspecific #diagnostics #wearabledevice #infectiousdisease #pandemicpreparedness #hometesting
ALSO IN THIS ISSUE
Diagnosing #preeclampsia early in pregnancy - finally
Good news about #heartdisease
#ctDNA edges towards clinical use
#CDC ends #birdflu emergency
Highest annual #measles cases in 33 years
#sensitiveandspecific #microsoftAI #diagnostics
open.substack.com/pub/sensitiv...
Diagnosing #preeclampsia early in pregnancy - finally
Good news about #heartdisease
#ctDNA edges towards clinical use
#CDC ends #birdflu emergency
Highest annual #measles cases in 33 years
#sensitiveandspecific #microsoftAI #diagnostics
open.substack.com/pub/sensitiv...
A harder look at Microsoft’s AI diagnostics platform
Volume 12, Issue 5 | July 10, 2025
open.substack.com
July 11, 2025 at 1:11 AM
ALSO IN THIS ISSUE
Diagnosing #preeclampsia early in pregnancy - finally
Good news about #heartdisease
#ctDNA edges towards clinical use
#CDC ends #birdflu emergency
Highest annual #measles cases in 33 years
#sensitiveandspecific #microsoftAI #diagnostics
open.substack.com/pub/sensitiv...
Diagnosing #preeclampsia early in pregnancy - finally
Good news about #heartdisease
#ctDNA edges towards clinical use
#CDC ends #birdflu emergency
Highest annual #measles cases in 33 years
#sensitiveandspecific #microsoftAI #diagnostics
open.substack.com/pub/sensitiv...
IN THIS ISSUE
#FDA approves #homesampling for HPV
Blood proteins allow ultra-early diagnosis of #liverdisease
Faster #antibiotic selection with updated mass-spec
New #sampletype: You won’t believe your ears
#sensitiveandspecific#diagnostics#samplecollection#AI
#oncology #massspectrometry#diabetes
#FDA approves #homesampling for HPV
Blood proteins allow ultra-early diagnosis of #liverdisease
Faster #antibiotic selection with updated mass-spec
New #sampletype: You won’t believe your ears
#sensitiveandspecific#diagnostics#samplecollection#AI
#oncology #massspectrometry#diabetes
AI mines primary-care data to diagnose cancer
Volume 11, Issue 20 | May 15, 2025
open.substack.com
May 16, 2025 at 3:54 AM
IN THIS ISSUE
#FDA approves #homesampling for HPV
Blood proteins allow ultra-early diagnosis of #liverdisease
Faster #antibiotic selection with updated mass-spec
New #sampletype: You won’t believe your ears
#sensitiveandspecific#diagnostics#samplecollection#AI
#oncology #massspectrometry#diabetes
#FDA approves #homesampling for HPV
Blood proteins allow ultra-early diagnosis of #liverdisease
Faster #antibiotic selection with updated mass-spec
New #sampletype: You won’t believe your ears
#sensitiveandspecific#diagnostics#samplecollection#AI
#oncology #massspectrometry#diabetes
ALSO IN THIS ISSUE
#mRNA in #liquidbiopsy could improve cancer Dx
Conclusions on post-cancer surveillance outdated
#USDA axes new testing for #salmonella rule
#Measles Outbreaks: Death count now three
#sensitiveandspecific #diagnostics #dianostictesting #diagnosticscreening #coloncancer
#mRNA in #liquidbiopsy could improve cancer Dx
Conclusions on post-cancer surveillance outdated
#USDA axes new testing for #salmonella rule
#Measles Outbreaks: Death count now three
#sensitiveandspecific #diagnostics #dianostictesting #diagnosticscreening #coloncancer
Don’t let perfect be the enemy of the good in colon cancer screening
Volume 11, Issue 19 | May 8, 2025
open.substack.com
May 9, 2025 at 4:33 AM
ALSO IN THIS ISSUE
#mRNA in #liquidbiopsy could improve cancer Dx
Conclusions on post-cancer surveillance outdated
#USDA axes new testing for #salmonella rule
#Measles Outbreaks: Death count now three
#sensitiveandspecific #diagnostics #dianostictesting #diagnosticscreening #coloncancer
#mRNA in #liquidbiopsy could improve cancer Dx
Conclusions on post-cancer surveillance outdated
#USDA axes new testing for #salmonella rule
#Measles Outbreaks: Death count now three
#sensitiveandspecific #diagnostics #dianostictesting #diagnosticscreening #coloncancer
Spotlight on Alzheimer’s: The biomarker race
#sensitiveandspecific #diagnostics #diagnostictesting #screening #alzheimers #alzheimersassociation #cognitivedecline #biomarkers #pTau #liquidbiopsy #pTau217 #pTau181
#sensitiveandspecific #diagnostics #diagnostictesting #screening #alzheimers #alzheimersassociation #cognitivedecline #biomarkers #pTau #liquidbiopsy #pTau217 #pTau181
Spotlight on Alzheimer’s: The biomarker race
Volume 11, Issue 18 | May 1, 2025
open.substack.com
May 2, 2025 at 1:38 AM
Spotlight on Alzheimer’s: The biomarker race
#sensitiveandspecific #diagnostics #diagnostictesting #screening #alzheimers #alzheimersassociation #cognitivedecline #biomarkers #pTau #liquidbiopsy #pTau217 #pTau181
#sensitiveandspecific #diagnostics #diagnostictesting #screening #alzheimers #alzheimersassociation #cognitivedecline #biomarkers #pTau #liquidbiopsy #pTau217 #pTau181
The Diagnostics Year in Review
#yearinreview #diagnostics #sensitiveandspecific #diagnostictesting #technology #AI #therapeutics #reimbursement #FDA #laboratorydevelopedtests #companiondiagnostics #liqidbiopsy #multiomics #hometesting #precisionmedicine #birdflu #measles
#yearinreview #diagnostics #sensitiveandspecific #diagnostictesting #technology #AI #therapeutics #reimbursement #FDA #laboratorydevelopedtests #companiondiagnostics #liqidbiopsy #multiomics #hometesting #precisionmedicine #birdflu #measles
The Diagnostics Year in Review
Volume 11, Issue 17 | April 24, 2025
open.substack.com
April 25, 2025 at 1:21 AM
IN THIS ISSUE
Rapid TB test using saliva
Could overuse of #CTscans raise cancer rates?
Where might a polygenic risk score fit in #prostatecancer screening?
A no-contact #skinmonitor
#BirdFlu Update: #Pasteurization kills virus
#sensitiveandspecific#diagnostics#lungcancer#tuberculosis#measles
Rapid TB test using saliva
Could overuse of #CTscans raise cancer rates?
Where might a polygenic risk score fit in #prostatecancer screening?
A no-contact #skinmonitor
#BirdFlu Update: #Pasteurization kills virus
#sensitiveandspecific#diagnostics#lungcancer#tuberculosis#measles
A breath test for lung cancer?
Volume 11, Issue 16 | April 17, 2025
open.substack.com
April 18, 2025 at 3:54 AM
IN THIS ISSUE
Rapid TB test using saliva
Could overuse of #CTscans raise cancer rates?
Where might a polygenic risk score fit in #prostatecancer screening?
A no-contact #skinmonitor
#BirdFlu Update: #Pasteurization kills virus
#sensitiveandspecific#diagnostics#lungcancer#tuberculosis#measles
Rapid TB test using saliva
Could overuse of #CTscans raise cancer rates?
Where might a polygenic risk score fit in #prostatecancer screening?
A no-contact #skinmonitor
#BirdFlu Update: #Pasteurization kills virus
#sensitiveandspecific#diagnostics#lungcancer#tuberculosis#measles
IN THIS ISSUE
#FDA decreases animal testing requirements for #monoclonalantibodies
#BirdFlu Update: 1,000 herds and counting
#Measles Outbreaks: Another child has died
#PCR detects seafood fraud
Blood test predicts improvement after spinal-cord injury
#Telehealth provides second-opinion options
#FDA decreases animal testing requirements for #monoclonalantibodies
#BirdFlu Update: 1,000 herds and counting
#Measles Outbreaks: Another child has died
#PCR detects seafood fraud
Blood test predicts improvement after spinal-cord injury
#Telehealth provides second-opinion options
When and how will we know if MCEDs are worth it?
Volume 11, Issue 15 | April 10, 2025
open.substack.com
April 11, 2025 at 4:42 AM
IN THIS ISSUE
#FDA decreases animal testing requirements for #monoclonalantibodies
#BirdFlu Update: 1,000 herds and counting
#Measles Outbreaks: Another child has died
#PCR detects seafood fraud
Blood test predicts improvement after spinal-cord injury
#Telehealth provides second-opinion options
#FDA decreases animal testing requirements for #monoclonalantibodies
#BirdFlu Update: 1,000 herds and counting
#Measles Outbreaks: Another child has died
#PCR detects seafood fraud
Blood test predicts improvement after spinal-cord injury
#Telehealth provides second-opinion options
ALSO IN THIS ISSUE
- #HHS #Layoffs
- Can a smell test diagnose the earliest stage of #cognitive impairment?
- A wearable computer?
- #Colonoscopy vs. #FIT: Acceptance and efficacy
- First Fully At-Home STI Test Approved
#sensitiveandspecific#diagnostics#FDA#LDT#AROMHA
#elasticfiber#athometest
- #HHS #Layoffs
- Can a smell test diagnose the earliest stage of #cognitive impairment?
- A wearable computer?
- #Colonoscopy vs. #FIT: Acceptance and efficacy
- First Fully At-Home STI Test Approved
#sensitiveandspecific#diagnostics#FDA#LDT#AROMHA
#elasticfiber#athometest
FDA’s Final Rule on LDTs is dead
Volume 11, Issue 14 | April 3, 2025
open.substack.com
April 4, 2025 at 3:04 AM
ALSO IN THIS ISSUE
- #HHS #Layoffs
- Can a smell test diagnose the earliest stage of #cognitive impairment?
- A wearable computer?
- #Colonoscopy vs. #FIT: Acceptance and efficacy
- First Fully At-Home STI Test Approved
#sensitiveandspecific#diagnostics#FDA#LDT#AROMHA
#elasticfiber#athometest
- #HHS #Layoffs
- Can a smell test diagnose the earliest stage of #cognitive impairment?
- A wearable computer?
- #Colonoscopy vs. #FIT: Acceptance and efficacy
- First Fully At-Home STI Test Approved
#sensitiveandspecific#diagnostics#FDA#LDT#AROMHA
#elasticfiber#athometest
#sensitiveandspecific #diagnostics #diagnosticscreening #sarcopenia #cardiovascularrisk #mammogram #postpartumdepression #ovariancancer #healthequity #medicalequity #cervicalcancer #endometrialcancer
Spotlight on Women’s Health
Volume 11, Issue 13 | March 27, 2025
open.substack.com
March 28, 2025 at 2:39 AM
ALSO IN THIS ISSUE:
Could smartwatches diagnose heart attacks?
Bird Flu Update: OPPR no longer staffed
Can a test of a hair sample rule out autism?
#sensitiveandspecific #diagnostics #diagnostictesting #AI #wearabledevice #heartattack #painmeasurement #painscale #birdflu #hairsample #autism
Could smartwatches diagnose heart attacks?
Bird Flu Update: OPPR no longer staffed
Can a test of a hair sample rule out autism?
#sensitiveandspecific #diagnostics #diagnostictesting #AI #wearabledevice #heartattack #painmeasurement #painscale #birdflu #hairsample #autism
Moving beyond the “smiley face” pain scale
Volume 11, Issue 12 | March 20, 2025
open.substack.com
March 21, 2025 at 2:31 AM
ALSO IN THIS ISSUE:
Could smartwatches diagnose heart attacks?
Bird Flu Update: OPPR no longer staffed
Can a test of a hair sample rule out autism?
#sensitiveandspecific #diagnostics #diagnostictesting #AI #wearabledevice #heartattack #painmeasurement #painscale #birdflu #hairsample #autism
Could smartwatches diagnose heart attacks?
Bird Flu Update: OPPR no longer staffed
Can a test of a hair sample rule out autism?
#sensitiveandspecific #diagnostics #diagnostictesting #AI #wearabledevice #heartattack #painmeasurement #painscale #birdflu #hairsample #autism
As the innovations kept coming, we did our best to keep up, focusing on diagnostic-related #technologies that we deemed likely to make the biggest impact.
#sensitiveandspecific #diagnostics #AI #artificialintelligence #cancerdetection #cardiology #neurology #obstetrics #radiology #yearinreview
#sensitiveandspecific #diagnostics #AI #artificialintelligence #cancerdetection #cardiology #neurology #obstetrics #radiology #yearinreview
Sensitive & Specific: The Year in AI
Volume 11, Issue 11 | March 13, 2025
open.substack.com
March 14, 2025 at 1:09 AM
As the innovations kept coming, we did our best to keep up, focusing on diagnostic-related #technologies that we deemed likely to make the biggest impact.
#sensitiveandspecific #diagnostics #AI #artificialintelligence #cancerdetection #cardiology #neurology #obstetrics #radiology #yearinreview
#sensitiveandspecific #diagnostics #AI #artificialintelligence #cancerdetection #cardiology #neurology #obstetrics #radiology #yearinreview
Admin. rehires some #FDA workers
Possible new method to find source of #inflammation
#Diagnostic pajamas
#BirdFlu update: Under right conditions, wind can spread virus
People say they want #pharmacogenomic testing - do they really?
#sensitiveandspecific#diagnostics#wearabledevice #sleepmonitor
Possible new method to find source of #inflammation
#Diagnostic pajamas
#BirdFlu update: Under right conditions, wind can spread virus
People say they want #pharmacogenomic testing - do they really?
#sensitiveandspecific#diagnostics#wearabledevice #sleepmonitor
Using the immune system itself to diagnose disease
Volume 11, Issue 9 | February 27, 2025
open.substack.com
February 28, 2025 at 1:36 AM
Admin. rehires some #FDA workers
Possible new method to find source of #inflammation
#Diagnostic pajamas
#BirdFlu update: Under right conditions, wind can spread virus
People say they want #pharmacogenomic testing - do they really?
#sensitiveandspecific#diagnostics#wearabledevice #sleepmonitor
Possible new method to find source of #inflammation
#Diagnostic pajamas
#BirdFlu update: Under right conditions, wind can spread virus
People say they want #pharmacogenomic testing - do they really?
#sensitiveandspecific#diagnostics#wearabledevice #sleepmonitor
ALSO IN THIS ISSUE
- Administration cuts #medicaldevicestaff at #FDA, Lab Leadership at #CDC / #CDRH
- #BirdFlu: Administration “accidentally” fires critical staff
- Bird Flu: Human to pet cat transmission
- Blood test for early #stroke diagnosis
#sensitiveandspecific#diagnostics#AI#staffcuts
- Administration cuts #medicaldevicestaff at #FDA, Lab Leadership at #CDC / #CDRH
- #BirdFlu: Administration “accidentally” fires critical staff
- Bird Flu: Human to pet cat transmission
- Blood test for early #stroke diagnosis
#sensitiveandspecific#diagnostics#AI#staffcuts
FDA regulation of AI: challenging before, now what?
Volume 11, Issue 8 | February 20, 2025
open.substack.com
February 21, 2025 at 2:32 AM
ALSO IN THIS ISSUE
- Administration cuts #medicaldevicestaff at #FDA, Lab Leadership at #CDC / #CDRH
- #BirdFlu: Administration “accidentally” fires critical staff
- Bird Flu: Human to pet cat transmission
- Blood test for early #stroke diagnosis
#sensitiveandspecific#diagnostics#AI#staffcuts
- Administration cuts #medicaldevicestaff at #FDA, Lab Leadership at #CDC / #CDRH
- #BirdFlu: Administration “accidentally” fires critical staff
- Bird Flu: Human to pet cat transmission
- Blood test for early #stroke diagnosis
#sensitiveandspecific#diagnostics#AI#staffcuts
ALSO IN THIS ISSUE
Will these two pTaus be the key to early Alzheimer’s dx?
AI decision support might help diagnose CRC earlier
Bird Flu Update: Asymptomatic infections in people
#sensitiveandspecific#diagnostics#diagnostictesting #alzheimers#AI#athometest#prostatecancer #colorectalcancer#birdflu
Will these two pTaus be the key to early Alzheimer’s dx?
AI decision support might help diagnose CRC earlier
Bird Flu Update: Asymptomatic infections in people
#sensitiveandspecific#diagnostics#diagnostictesting #alzheimers#AI#athometest#prostatecancer #colorectalcancer#birdflu
A potential at-home test for aggressive prostate cancer
Volume 11, Issue 7 | February 13, 2025
open.substack.com
February 14, 2025 at 1:20 AM
ALSO IN THIS ISSUE
Will these two pTaus be the key to early Alzheimer’s dx?
AI decision support might help diagnose CRC earlier
Bird Flu Update: Asymptomatic infections in people
#sensitiveandspecific#diagnostics#diagnostictesting #alzheimers#AI#athometest#prostatecancer #colorectalcancer#birdflu
Will these two pTaus be the key to early Alzheimer’s dx?
AI decision support might help diagnose CRC earlier
Bird Flu Update: Asymptomatic infections in people
#sensitiveandspecific#diagnostics#diagnostictesting #alzheimers#AI#athometest#prostatecancer #colorectalcancer#birdflu
ALSO IN THIS ISSUE
A biomarker for severe Long COVID
Bird Flu Update: Wild bird version of virus found in cattle
Why the resistance to using biomarkers to Dx Alzheimer’s?
#sensitiveandspecific#diagnostics#biomedicaldiagnostics #biomarker#LongCOVID#asthma#noninvasivetest#birdflu #H5N1#alzheimers
A biomarker for severe Long COVID
Bird Flu Update: Wild bird version of virus found in cattle
Why the resistance to using biomarkers to Dx Alzheimer’s?
#sensitiveandspecific#diagnostics#biomedicaldiagnostics #biomarker#LongCOVID#asthma#noninvasivetest#birdflu #H5N1#alzheimers
A noninvasive test that could improve asthma treatment
Volume 11, Issue 6 | February 6, 2025
open.substack.com
February 7, 2025 at 2:02 AM
ALSO IN THIS ISSUE
A biomarker for severe Long COVID
Bird Flu Update: Wild bird version of virus found in cattle
Why the resistance to using biomarkers to Dx Alzheimer’s?
#sensitiveandspecific#diagnostics#biomedicaldiagnostics #biomarker#LongCOVID#asthma#noninvasivetest#birdflu #H5N1#alzheimers
A biomarker for severe Long COVID
Bird Flu Update: Wild bird version of virus found in cattle
Why the resistance to using biomarkers to Dx Alzheimer’s?
#sensitiveandspecific#diagnostics#biomedicaldiagnostics #biomarker#LongCOVID#asthma#noninvasivetest#birdflu #H5N1#alzheimers
ALSO IN THIS ISSUE:
-Could MCEDs work better in symptomatic patients?
-Using speech to diagnose depression
-Bird Flu Update: Ducks with H5N9 raise reassortment concern
#sensitiveandspecific#diagnostics#diagnosticscreening #bladdercancer#athometest#MCED#AI#depression #AIinDiagnostics#birdflu
-Could MCEDs work better in symptomatic patients?
-Using speech to diagnose depression
-Bird Flu Update: Ducks with H5N9 raise reassortment concern
#sensitiveandspecific#diagnostics#diagnosticscreening #bladdercancer#athometest#MCED#AI#depression #AIinDiagnostics#birdflu
An at-home test for bladder cancer?
Volume 11, Issue 5 | January 30, 2025
open.substack.com
January 31, 2025 at 1:29 AM
ALSO IN THIS ISSUE:
-Could MCEDs work better in symptomatic patients?
-Using speech to diagnose depression
-Bird Flu Update: Ducks with H5N9 raise reassortment concern
#sensitiveandspecific#diagnostics#diagnosticscreening #bladdercancer#athometest#MCED#AI#depression #AIinDiagnostics#birdflu
-Could MCEDs work better in symptomatic patients?
-Using speech to diagnose depression
-Bird Flu Update: Ducks with H5N9 raise reassortment concern
#sensitiveandspecific#diagnostics#diagnosticscreening #bladdercancer#athometest#MCED#AI#depression #AIinDiagnostics#birdflu
ALSO IN THIS ISSUE
AI helps ultrasonographers image lungs
Cross-border collaboration helps diagnose rare diseases
A blood test for asthma?
Bird flu update: CDC updates risk assessment, turkeys must be tested
#sensitiveandspecific#diagnostics#AI#birdflu#raredisease #colonoscopy#bloodtest#asthma
AI helps ultrasonographers image lungs
Cross-border collaboration helps diagnose rare diseases
A blood test for asthma?
Bird flu update: CDC updates risk assessment, turkeys must be tested
#sensitiveandspecific#diagnostics#AI#birdflu#raredisease #colonoscopy#bloodtest#asthma
After normal colonoscopy, can you wait 15 years?
Volume 11, Issue 4 | January 23, 2025
open.substack.com
January 24, 2025 at 1:34 AM
ALSO IN THIS ISSUE
AI helps ultrasonographers image lungs
Cross-border collaboration helps diagnose rare diseases
A blood test for asthma?
Bird flu update: CDC updates risk assessment, turkeys must be tested
#sensitiveandspecific#diagnostics#AI#birdflu#raredisease #colonoscopy#bloodtest#asthma
AI helps ultrasonographers image lungs
Cross-border collaboration helps diagnose rare diseases
A blood test for asthma?
Bird flu update: CDC updates risk assessment, turkeys must be tested
#sensitiveandspecific#diagnostics#AI#birdflu#raredisease #colonoscopy#bloodtest#asthma