Manuel Kaulich
@manuelkaulich.bsky.social
Professor @ Goethe Uni & IBC2-GU, Co-founder of Vivlion. #BerlinER #FrankfurtER
Reposted by Manuel Kaulich
Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉
www.nature.com/articles/s41...
We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!
🧵
www.nature.com/articles/s41...
We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!
🧵
August 4, 2025 at 1:52 PM
Our paper benchmarking foundation models for perturbation effect prediction is finally published 🎉🥳🎉
www.nature.com/articles/s41...
We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!
🧵
www.nature.com/articles/s41...
We show that none of the available* models outperform simple linear baselines. Since the original preprint, we added more methods, metrics, and prettier figures!
🧵
In times when science must defend itself, the decision by the German Research Foundation (DFG) to significantly support German universities through the Excellence Initiative for the next seven years is a signal that stands unparalleled.
www.dfg.de/en/news/news...
www.dfg.de/en/news/news...
Announcement of Clusters of Excellence to Receive Funding in the Future, Thursday, 22 May 2025, from approx. 5 pm
www.dfg.de
May 22, 2025 at 6:03 PM
In times when science must defend itself, the decision by the German Research Foundation (DFG) to significantly support German universities through the Excellence Initiative for the next seven years is a signal that stands unparalleled.
www.dfg.de/en/news/news...
www.dfg.de/en/news/news...
Such a wonderful example of what genetic screens can tell us about human patho/physiology.
Cudos @mgarnett.bsky.social, Fiona Behan and many more.
Cudos @mgarnett.bsky.social, Fiona Behan and many more.
Six years after the discovery of WRN synthetic lethality in MSI cancers, WRN inhibitors hit center stage again today at #aacr25 with report of the first in human phase 1 trial data for RO7589831. Can’t wait to see it!
April 27, 2025 at 3:47 PM
Such a wonderful example of what genetic screens can tell us about human patho/physiology.
Cudos @mgarnett.bsky.social, Fiona Behan and many more.
Cudos @mgarnett.bsky.social, Fiona Behan and many more.
Congratulations! & thanks for letting us contribute to this wonderful story.
I am excited to announce the publication of our paper in @molsystbiol.org!
I am incredibly grateful for this wonderful collaboration with the team of @manuelkaulich.bsky.social. A big thank you to @yasirde.bsky.social, @shawangela.bsky.social and to @maxbillmann.bsky.social!
doi.org/10.1038/s443...
I am incredibly grateful for this wonderful collaboration with the team of @manuelkaulich.bsky.social. A big thank you to @yasirde.bsky.social, @shawangela.bsky.social and to @maxbillmann.bsky.social!
doi.org/10.1038/s443...
BaCoN (Balanced Correlation Network) improves prediction of gene buffering | Molecular Systems Biology
imageimageFunctional buffering between pairs of genes can be predicted by correlating the knockout
fitness effect of one with the expression of another gene across cell lines. BaCoN
(Balanced Cor...
www.embopress.org
April 24, 2025 at 1:55 PM
Congratulations! & thanks for letting us contribute to this wonderful story.
Reposted by Manuel Kaulich
A record low…. only 16% of Germans think that Germany can trust the US.
A record fast…. never before lost a US president support for its political agenda that fast.
www.spiegel.de/politik/deut...
A record fast…. never before lost a US president support for its political agenda that fast.
www.spiegel.de/politik/deut...
Deutschlandtrend der ARD: Nur 16 Prozent halten USA noch für vertrauenswürdig
Bleiben die USA der wichtigste Verbündete Europas? Die große Mehrheit in Deutschland glaubt einer Umfrage zufolge offenbar nicht mehr an eine gute Zusammenarbeit.
www.spiegel.de
March 8, 2025 at 12:56 PM
A record low…. only 16% of Germans think that Germany can trust the US.
A record fast…. never before lost a US president support for its political agenda that fast.
www.spiegel.de/politik/deut...
A record fast…. never before lost a US president support for its political agenda that fast.
www.spiegel.de/politik/deut...
If a team wished to include combinatorial gene perturbation and bioinformatics in their program, please reach out.
Just announced! Seven new Cancer Grand Challenges – with awards of up to £20m – available for research teams around the world to tackle the biggest questions in cancer research.
Read more: cruk.ink/4ha3LgZ 1/2
Read more: cruk.ink/4ha3LgZ 1/2
March 7, 2025 at 5:35 AM
If a team wished to include combinatorial gene perturbation and bioinformatics in their program, please reach out.
Reposted by Manuel Kaulich
New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le....
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
February 25, 2025 at 4:17 PM
New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le....
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.
February 23, 2025 at 7:01 PM
Interested in synthetic lethality or how functional genomics can be leveraged for clinical benefit?
Then, this is the place to meet:
www.grc.org/synthetic-le...
Then, this is the place to meet:
www.grc.org/synthetic-le...
2025 Synthetic Lethality Approaches in Oncology Conference GRC
The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
February 13, 2025 at 7:53 AM
Interested in synthetic lethality or how functional genomics can be leveraged for clinical benefit?
Then, this is the place to meet:
www.grc.org/synthetic-le...
Then, this is the place to meet:
www.grc.org/synthetic-le...
If you search for unexpected phenotypes (genetic interactions), aren't they expected when observed? 🤔
February 2, 2025 at 5:16 PM
If you search for unexpected phenotypes (genetic interactions), aren't they expected when observed? 🤔
Which rate do you consider appropriate,
10% or 1% ?
10% or 1% ?
Thinking about grant alternatives to fund basic research?
Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?
Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?
February 1, 2025 at 1:50 PM
Which rate do you consider appropriate,
10% or 1% ?
10% or 1% ?
Thinking about grant alternatives to fund basic research?
Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?
Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?
January 30, 2025 at 9:06 PM
Thinking about grant alternatives to fund basic research?
Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?
Provocative thought - How about getting a royalty rate per accessed publication (per corresponding author)?
Reposted by Manuel Kaulich
📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)
Highly recommended!
Register here
grc.org/synthetic-le...
Highly recommended!
Register here
grc.org/synthetic-le...
2025 Synthetic Lethality Approaches in Oncology Conference GRC
The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.
grc.org
January 29, 2025 at 8:05 PM
📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)
Highly recommended!
Register here
grc.org/synthetic-le...
Highly recommended!
Register here
grc.org/synthetic-le...
Reposted by Manuel Kaulich
FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here:
bit.ly/40cIfSl
@fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social
bit.ly/40cIfSl
@fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social
Network Biology
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
bit.ly
January 14, 2025 at 8:29 PM
FYI 🔔The abstract deadline for #cshlnetworks is coming up - Jan. 27th! Register to submit your abstract here:
bit.ly/40cIfSl
@fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social
bit.ly/40cIfSl
@fritzroth.bsky.social @jsvanleeuwen.bsky.social @pedrobeltrao.bsky.social
Hallo Bluesky!
Wir sind die Deutsche Forschungsgemeinschaft. #DFG Als Selbstverwaltungsorganisation der #Wissenschaft in Deutschland fördern wir erkenntnisgeleitete #Forschung. Hier erhaltet Ihr Infos u.a. zu Förderangeboten, Ausschreibungen und Anträgen. Wir freuen uns auf den Austausch!
Wir sind die Deutsche Forschungsgemeinschaft. #DFG Als Selbstverwaltungsorganisation der #Wissenschaft in Deutschland fördern wir erkenntnisgeleitete #Forschung. Hier erhaltet Ihr Infos u.a. zu Förderangeboten, Ausschreibungen und Anträgen. Wir freuen uns auf den Austausch!
January 14, 2025 at 6:49 PM
Reposted by Manuel Kaulich
Make your mark on the future of #PrecisionMedicine
at #CRISPR25!
Showcase #CRISPR methods for modulating the genome at scale🧬
𝗦𝘂𝗯𝗺𝗶𝘁 𝗮𝗻 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝟰 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 for a chance to build your professional profile at the forefront of a global community.
📎 bit.ly/3BDXOtP
at #CRISPR25!
Showcase #CRISPR methods for modulating the genome at scale🧬
𝗦𝘂𝗯𝗺𝗶𝘁 𝗮𝗻 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝟰 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 for a chance to build your professional profile at the forefront of a global community.
📎 bit.ly/3BDXOtP
January 7, 2025 at 9:12 AM
Make your mark on the future of #PrecisionMedicine
at #CRISPR25!
Showcase #CRISPR methods for modulating the genome at scale🧬
𝗦𝘂𝗯𝗺𝗶𝘁 𝗮𝗻 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝟰 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 for a chance to build your professional profile at the forefront of a global community.
📎 bit.ly/3BDXOtP
at #CRISPR25!
Showcase #CRISPR methods for modulating the genome at scale🧬
𝗦𝘂𝗯𝗺𝗶𝘁 𝗮𝗻 𝗮𝗯𝘀𝘁𝗿𝗮𝗰𝘁 𝗯𝘆 𝟰 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 for a chance to build your professional profile at the forefront of a global community.
📎 bit.ly/3BDXOtP
Are you interested in how genes/proteins interact to regulate cellular and organismal physiology?
If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting.
meetings.cshl.edu/meetings.asp...
If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting.
meetings.cshl.edu/meetings.asp...
Network Biology
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
meetings.cshl.edu
December 19, 2024 at 7:27 AM
Are you interested in how genes/proteins interact to regulate cellular and organismal physiology?
If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting.
meetings.cshl.edu/meetings.asp...
If so, let's grab a coffee at the upcoming #CSHL Network Biology meeting.
meetings.cshl.edu/meetings.asp...
I messed up my earlier message by using the wrong link/date. So here is the correction!!
See you in Hinxton (2–4 April, 2025)
coursesandconferences.wellcomeconnectingscience.org/event/crispr...
See you in Hinxton (2–4 April, 2025)
coursesandconferences.wellcomeconnectingscience.org/event/crispr...
CRISPR and Beyond: Perturbations at Scale to Understand Genomes — 20250402
Exploring methods to modulate the genome at scale
coursesandconferences.wellcomeconnectingscience.org
December 11, 2024 at 12:26 PM
I messed up my earlier message by using the wrong link/date. So here is the correction!!
See you in Hinxton (2–4 April, 2025)
coursesandconferences.wellcomeconnectingscience.org/event/crispr...
See you in Hinxton (2–4 April, 2025)
coursesandconferences.wellcomeconnectingscience.org/event/crispr...
Wow !
Not only the topic, but look at this line up of speakers.
How can one not go?
Not only the topic, but look at this line up of speakers.
How can one not go?
Excited to launch a new Gordon Research Conference on synthetic lethality in oncology. Great cutting edge program, superb speakers and lots of networking opportunities. Applications open.
www.grc.org/synthetic-le...
www.grc.org/synthetic-le...
2025 Synthetic Lethality Approaches in Oncology Conference GRC
The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.
www.grc.org
November 28, 2024 at 5:19 AM
Wow !
Not only the topic, but look at this line up of speakers.
How can one not go?
Not only the topic, but look at this line up of speakers.
How can one not go?
Reposted by Manuel Kaulich
Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️
November 25, 2024 at 1:47 PM
Look who's here
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️
@pnas.org ✔️
@science.org ✔️
@naturecellbiology.bsky.social ✔️
@natrevgenet.bsky.social ✔️
@naturebiotech.bsky.social ✔️
@naturemicrobiol.bsky.social ✔️
@naturechemistry.bsky.social ✔️
@genesdev.bsky.social ✔️
@cellchembiol.bsky.social ✔️
@genomeresearch.bsky.social ✔️
@jcellbiol.bsky.social ✔️
I’ll be pitching a Mosbacher Kolloquium at the next annual meeting of the German Society for Biochemistry and Molecular Biology (GBM).
The topic will be „Advances in gene regulation, editing, and medicine“.
Anything that you’d like to be highlighted?
gbm-online.de/en/the-gbm-2...
The topic will be „Advances in gene regulation, editing, and medicine“.
Anything that you’d like to be highlighted?
gbm-online.de/en/the-gbm-2...
GBM-Startseite - Homepage of the German Society for Biochemistry and Molecular Biology (GBM, Gesellschaft für Biochemie und Molekularbiologie e.V.)
The German Society for Biochemistry and Molecular Biology - GBM is an interest representation for scientists. Contents are scientific meetings, study groups (Fachgruppen), journals Biospektrum and Bio...
gbm-online.de
November 24, 2024 at 5:38 PM
I’ll be pitching a Mosbacher Kolloquium at the next annual meeting of the German Society for Biochemistry and Molecular Biology (GBM).
The topic will be „Advances in gene regulation, editing, and medicine“.
Anything that you’d like to be highlighted?
gbm-online.de/en/the-gbm-2...
The topic will be „Advances in gene regulation, editing, and medicine“.
Anything that you’d like to be highlighted?
gbm-online.de/en/the-gbm-2...
Reposted by Manuel Kaulich
Join us for the 6th CRISPR and Beyond Conference on 2-4 April 2025!🧬 A must-attend event for researchers in high-throughput screening and #GeneEditing, exploring emerging technologies and models. #CRISPR25
👉Programme and registration: bit.ly/3Amz34N
👉Programme and registration: bit.ly/3Amz34N
November 19, 2024 at 2:40 PM
Join us for the 6th CRISPR and Beyond Conference on 2-4 April 2025!🧬 A must-attend event for researchers in high-throughput screening and #GeneEditing, exploring emerging technologies and models. #CRISPR25
👉Programme and registration: bit.ly/3Amz34N
👉Programme and registration: bit.ly/3Amz34N
Incredibly proud of my PhD student @MartinWegner for receiving this year’s PhD award of the @GoetheUniversityFrankfurt. 🎉🎊🥳🍾
I guess with 11 papers, multiple patents, and a spinoff, it’s kind of deserved 🤔
I guess with 11 papers, multiple patents, and a spinoff, it’s kind of deserved 🤔
November 19, 2024 at 7:04 PM
Incredibly proud of my PhD student @MartinWegner for receiving this year’s PhD award of the @GoetheUniversityFrankfurt. 🎉🎊🥳🍾
I guess with 11 papers, multiple patents, and a spinoff, it’s kind of deserved 🤔
I guess with 11 papers, multiple patents, and a spinoff, it’s kind of deserved 🤔