Manish Butte
@manishbutte.bsky.social
Pediatric immunologist specializing in inborn errors of immunity, T cell Immunologist, Professor and Division Chief, UCLA Dept of Pediatrics, Microbiology / Immunology, and Human Genetics
Intriguing paper from @josephsunlab.bsky.social about IL12 signaling that comes *before* TCR signaling leading to memory. Re "delayed expression" of IL12R in CD8 T cells, I wonder if that's related to the change from short to full-length transcripts that occurs upon activation (see PMID: 23024274)?
Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells?
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes
Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues …
www.sciencedirect.com
January 31, 2026 at 4:20 PM
Intriguing paper from @josephsunlab.bsky.social about IL12 signaling that comes *before* TCR signaling leading to memory. Re "delayed expression" of IL12R in CD8 T cells, I wonder if that's related to the change from short to full-length transcripts that occurs upon activation (see PMID: 23024274)?
Yay! I'll be there, and speaking on our use of machine learning at UCLA to find undiagnosed patients with immune deficiency diseases.
UC Health CDI2 upcoming conference!
Thriving through change: Adapting, Advancing, Achieving
Stellar listening of speakers, likes of which include @kdpsingh.bsky.social!
Register
👇
na.eventscloud.com/website/5224...
Thriving through change: Adapting, Advancing, Achieving
Stellar listening of speakers, likes of which include @kdpsingh.bsky.social!
Register
👇
na.eventscloud.com/website/5224...
Home
na.eventscloud.com
January 28, 2026 at 12:12 AM
Yay! I'll be there, and speaking on our use of machine learning at UCLA to find undiagnosed patients with immune deficiency diseases.
This is a fantastic article by the @fletcherlabucb.bsky.social at Berkeley about macrophages assessing and eating the cells they bump into based on their membrane tension. I wonder if regulatory T cells, which also perform trogocytosis, use a similar mechanism (not FcγR-based, obviously).
How does a macrophage decide to eat or simply nibble? Check out our latest paper! You can also read this nice review. Congrats Caitlin for leading this amazing work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Target cell cortical tension regulates macrophage trogocytosis - Nature Cell Biology
Cornell et al. show that target cells with low cortical tension induce macrophages to preferentially trogocytose, or engulf in small fragments, whereas target cells with high cortical tension tend tow...
www.nature.com
January 22, 2026 at 6:54 PM
This is a fantastic article by the @fletcherlabucb.bsky.social at Berkeley about macrophages assessing and eating the cells they bump into based on their membrane tension. I wonder if regulatory T cells, which also perform trogocytosis, use a similar mechanism (not FcγR-based, obviously).
Cool advance in the epigenetics of Lamarckism. I wonder if a recent history of infections in fathers-to-be can be encoded in the epigenetics of sperm and passed down as well (e.g., microRNAs or chromatin organization at interferon response genes after viral infection).
Male mice that exercise can pass their newly gained fitness on to male offspring.
If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
If the same holds true in humans, researchers say, fathers could help improve the health of any future children by staying in shape themselves. https://scim.ag/47igpZm
Well-exercised male mice appear to pass fitness to their male offspring
Surprising epigenetic effect relies on snippets of RNA packaged within sperm
scim.ag
October 13, 2025 at 2:01 PM
Cool advance in the epigenetics of Lamarckism. I wonder if a recent history of infections in fathers-to-be can be encoded in the epigenetics of sperm and passed down as well (e.g., microRNAs or chromatin organization at interferon response genes after viral infection).
Melissa Lechner's group at UCLA identified both CD4+ (Tfh) and CD8+ (Tc1) T cells as drivers of the autoimmune diabetes that arises after anti-PD1 therapy, and showed the nonspecific JAK inhib ruxolitinib could prevent it! Wow. My suspicion is that targeting IFNg-STAT1 alone probably is enough.
Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy @jci-insight.bsky.social
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
July 9, 2025 at 5:16 PM
Melissa Lechner's group at UCLA identified both CD4+ (Tfh) and CD8+ (Tc1) T cells as drivers of the autoimmune diabetes that arises after anti-PD1 therapy, and showed the nonspecific JAK inhib ruxolitinib could prevent it! Wow. My suspicion is that targeting IFNg-STAT1 alone probably is enough.
One the many advances in this incredible paper by Columbia's Milner and Izar labs shows that GOF variants in PIK3CD are not all that rare, including p.M285T that occurs in 1/8000, and is correlated with autoimmune diseases. There are many more APDS patients lurking out there! #IEI #raredisease
Now online! Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment
Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment
In lieu of traditional genetic variant testing approaches, an approach using scalable variant classification in primary human T cells with a clinically relevant readout can inform rapid diagnosis and treatment of inborn errors of immunity.
dlvr.it
June 21, 2025 at 2:47 PM
One the many advances in this incredible paper by Columbia's Milner and Izar labs shows that GOF variants in PIK3CD are not all that rare, including p.M285T that occurs in 1/8000, and is correlated with autoimmune diseases. There are many more APDS patients lurking out there! #IEI #raredisease
New antifungals are much needed -- 41 of these patients receiving olorofim had coccidioidomycosis. #valleyfever
New hope for hard-to-treat fungal infections: Phase 2b results show #Olorofim is effective and well-tolerated in patients with few or no treatment options.
Read in The Lancet Infectious Diseases 👉 www.sciencedirect.com/science/arti...
#IFD #Antifungals #ClinicalTrials
Read in The Lancet Infectious Diseases 👉 www.sciencedirect.com/science/arti...
#IFD #Antifungals #ClinicalTrials
Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study
Only a small number of antifungal therapies for invasive fungal disease (IFD) are currently available, and many pathogens are resistant to one or more…
www.sciencedirect.com
June 18, 2025 at 4:06 PM
New antifungals are much needed -- 41 of these patients receiving olorofim had coccidioidomycosis. #valleyfever
Reposted by Manish Butte
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 7, 2025 at 11:33 PM
⚠️ Effective Monday 2/10/25, NIH indirect rate capped at 15%. Applies to existing & future grants.
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
—> Deep budget cuts & program closures coming to a university near you.
Is this the break the glass moment for university administrators who have been silent so far about the attack on science?
Bravo to Paul Bollyky @pbollyky.bsky.social at Stanford for his lab's paper showing that complementary groups of phage can be mixed to provide broad and effective antimicrobial therapy against Pseudomonas and Staph infections. Brilliant work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A blueprint for broadly effective bacteriophage-antibiotic cocktails against bacterial infections - Nature Communications
The application of phage therapy for multidrug-resistant infections is mainly limited to personalized therapy due to the narrow host range of individual phages. Here, Kim et al. identify groups of pha...
www.nature.com
December 4, 2024 at 10:01 PM
Bravo to Paul Bollyky @pbollyky.bsky.social at Stanford for his lab's paper showing that complementary groups of phage can be mixed to provide broad and effective antimicrobial therapy against Pseudomonas and Staph infections. Brilliant work!
www.nature.com/articles/s41...
www.nature.com/articles/s41...