#WhoWantsToLiveForever

Its not so awesome that they revived 7000 year old algae.. (its diatomea it would have done it itself)

But by reviving these ancient cells, they gain a glimpse into past marine ecosystems, offering invaluable insights into how marine life adapts to changing environments. 🧬

#DoOrDie #DNADamageResponse

Thats a cool story :

When a cells DNA is damaged, and needs a quick reaction, its actually the buildup of (errorenous) RNA that through ribosome confusion and bumping into each other actually signals the quick response for apoptosis. Makes a lot of sense.

#dopamine doesnt flood in brain but is instead released in disparate hotspots with millisecond precision – which suggests the brain can selectively target small neural populations with the neurotransmitter to fine-tune specific behaviors or decisions!!

#NoPainNoGain

newatlas.com/mental-healt...

#booksky

#baseEditing #personalizedMedicine
#precisionGeneEditing

We are there!! 💛🧬

As of June, at least 20 clinical trials with base or prime editors are underway. The newer base and prime editing medicines modify or insert specific nucleotides into the DNA without creating double-stranded breaks.

we recently found some really neat RNA-guided DNA-cutting systems in phages. Despite remarkable similarities to CRISPR systems, including encoding guide RNAs in arrays, they appear entirely evolutionarily distinct (but definitely related to snoRNAs 🤓)
We decided to call them TIGR-Tas systems 🐯

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

#TransposableElements altho abundant in the human genome, are repressed by methylation and chromatin modifications.

Here authors show another mechanism of repression; hierarchical chromatin topology (TADs) - when disrupted they can lead to co-option of LTRs as alternative promotors of #oncogenes!

This is too cute not to be shared. And its weekend. Light read time.

The experiment was: can claude ai run a physical shop. The answer is of course no. Poor claude(ius) ended up having an identity crisis trying to please everyone ❤️

LOVE to encounter a good review! Feels like reading what should become a textbook in comparative immunology!

Different organisms make intentional changes to their DNA, relying on similar mechanisms, function usually for immune defens or pathogenicity.

Thanks authors
@sebastianevda.bsky.social

Another day, another wonder;

Archea parasite with a circular genome of only 238Kbp (!) found within a dinoflagellate.

It only encodes for replicative machinery: can replicate but not sustain itself, making that line between life and non-life blurry! What a life

www.biorxiv.org/content/10.1...

Op op!

Google introduces AlphaGenome - their tool to predict effect of mutations, including gene expression, splicing patterns, chromatin accessability, 3d genome structure.

Also first model to predict splice junctions from sequence.

Lets see how it works!

#AlphaGenome #google #genomics

This is pretty cool! Turns out genome doubling occurs in one third of metastatic cancers!

Seems that during metastasis cancer cells tend to evolve by maximizing CNAs, while not generating too many mutations that could potentially stimulate an immune response.
#cancerEvolution

One last thanks to the #TCTeAC organisers, especially @svobodalab.bsky.social‬. And shoutout to all whom I met throughout the killing game: @majakuzman.bsky.social for organising, @da-bar.bsky.social for bodyguarding, @valeriyk1.bsky.social for scouting, @itaiyanai.bsky.social for enabling, /1

Would you trust a single base edit to rewrite your future? :)

this could be a cool thing to follow up in few years.

Eli Lilly just spent a billion dollars for a single base editing drug that lowers LDL levels by 50% by silencing PCSK9 gene in the liver with a single-course therapy.