Longhua Guo
@longhuaguo.bsky.social
Genetics | Genomics | Aging, Regeneration and Rejuvenation. Assistant Professor @ U of Michigan. Lab: guolabagingreg.com
Pinned
Longhua Guo
@longhuaguo.bsky.social
· Apr 12
Regeneration leads to global tissue rejuvenation in aging sexual planarians - Nature Aging
The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immort...
www.nature.com
The article: Regeneration leads to global tissue rejuvenation in aging sexual planarians
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Longhua Guo
ISRB Zone 3 Webinar this Friday (Oct 17th). @isrbio.bsky.social Aging and Regeneration with Longhua Guo @longhuaguo.bsky.social and Kevin Murach @kevinmurachphd.bsky.social
October 13, 2025 at 3:27 PM
ISRB Zone 3 Webinar this Friday (Oct 17th). @isrbio.bsky.social Aging and Regeneration with Longhua Guo @longhuaguo.bsky.social and Kevin Murach @kevinmurachphd.bsky.social
Reposted by Longhua Guo
Science has already saved countless lives and will save many more if we let it. Hearing firsthand from patients whose lives have been saved by medical research (tinyurl.com/m65339fh) shows how vital this funding is, even for those lucky enough not to have needed it yet.
Please share
#ScienceSavedMe
Please share
#ScienceSavedMe
September 3, 2025 at 10:12 PM
Science has already saved countless lives and will save many more if we let it. Hearing firsthand from patients whose lives have been saved by medical research (tinyurl.com/m65339fh) shows how vital this funding is, even for those lucky enough not to have needed it yet.
Please share
#ScienceSavedMe
Please share
#ScienceSavedMe
Reposted by Longhua Guo
Registration for “ReBilD 2025” (Emerging Leaders in Regenerative Biology and Development) is now open! Gain hands-on training with diverse regenerating animal models and attend daily lectures by leaders in the field. Please RT. mdibl.org/course/rebil... @mdibiolab.bsky.social
ReBilD: Emerging Leaders in Regenerative Biology and Development 2025 – MDI Biological Laboratory
mdibl.org
December 2, 2024 at 7:51 PM
Registration for “ReBilD 2025” (Emerging Leaders in Regenerative Biology and Development) is now open! Gain hands-on training with diverse regenerating animal models and attend daily lectures by leaders in the field. Please RT. mdibl.org/course/rebil... @mdibiolab.bsky.social
Rejuvenation in planarians. Check out the details in this link: www.nature.com/nataging?gcl... @nataging.nature.com
Nature Aging
How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the ...
www.nature.com
May 20, 2025 at 6:53 PM
Rejuvenation in planarians. Check out the details in this link: www.nature.com/nataging?gcl... @nataging.nature.com
Decelerated aging in old mice skeletal muscle after regeneration. This phenotype measured with DNA methylation clock was further enhanced with senolytics treatment.
Chambers et al. “At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle” #myoblue onlinelibrary.wiley.com/doi/full/10....
At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle
Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targe...
onlinelibrary.wiley.com
April 22, 2025 at 5:53 PM
Decelerated aging in old mice skeletal muscle after regeneration. This phenotype measured with DNA methylation clock was further enhanced with senolytics treatment.
Reposted by Longhua Guo
Cool data here. We have some mouse data (regeneration, not amputation) that supports this! Stay tuned and great stuff @longhuaguo.bsky.social #myoblue @natureaging.bsky.social
We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotypes were reversed to youthful states.
April 13, 2025 at 12:08 PM
Cool data here. We have some mouse data (regeneration, not amputation) that supports this! Stay tuned and great stuff @longhuaguo.bsky.social #myoblue @natureaging.bsky.social
We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotypes were reversed to youthful states.
April 12, 2025 at 6:21 PM
We identified aging-associated changes in sexual strains of the extremely long-lived planarian Schmidtea mediterranea. Following amputation and regeneration in older animals, aging-associated phenotypes were reversed to youthful states.
Reposted by Longhua Guo
Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea, and global reversal of such changes after regeneration.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Regeneration leads to global tissue rejuvenation in aging sexual planarians - Nature Aging
The freshwater planarian S. mediterranea is an important model organism for regeneration research but its use in aging research is little explored and S. mediterranea is commonly referred to as immort...
doi.org
April 7, 2025 at 7:26 AM
Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea, and global reversal of such changes after regeneration.
doi.org/10.1038/s435...
doi.org/10.1038/s435...
Reposted by Longhua Guo
We are grateful to @isrbio.bsky.social for their support of the ReBilD course @mdibiolab.bsky.social. mdibl.org/course/rebil... Please RT. 🙌
February 7, 2025 at 5:51 PM
We are grateful to @isrbio.bsky.social for their support of the ReBilD course @mdibiolab.bsky.social. mdibl.org/course/rebil... Please RT. 🙌
Reposted by Longhua Guo
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.
November 17, 2024 at 2:47 PM
We need to have a ‘code of conduct’ for reviewing manuscripts, like (1) if you say that something is not novel then provide the reference. (2) If you propose an experiment, state precisely to which claim it is crucial. (3) If you want to say something nasty then sign your name.