Pietro Berico
@locusbearico.bsky.social
Researcher at NYU Langone. PhD at IGBMC. MSc at UNIMIB. 3D chromatin & melanoma
Pinned
Pietro Berico
@locusbearico.bsky.social
· Dec 22
A targetable developmental program co-regulates angiogenesis and immune evasion
Ultraviolet (UV)-induced DNA mutations produce genetic drivers of cutaneous melanoma initiation and numerous neoantigens that can trigger anti-tumor immune responses in the host. Consequently, melanom...
www.biorxiv.org
If you are looking for an holiday read, check out our new story on how HOXD13 promotes melanoma growth! Others stories are coming soon thanks to my mentor and partner in crime Eva Hernando at @nyulangonepccsm.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pietro Berico
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
August 28, 2025 at 3:15 PM
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com) paper, Miranda Hunter (@mrndhntr.bsky.social) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
Another great preprint out from the Hernando lab, lead by Maria Gomez and Allie Kartz. Did you know that melanoma brain metastasis upregulate the carnosine dipeptidase CNDP1 through MITF to prevent intracellular copper accumulation?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis
Brain metastatic cells undergo metabolic adaptations, such as increased reliance on oxidative phosphorylation. Integrating proteomic and transcriptomic profiling of patient samples revealed a consiste...
www.biorxiv.org
April 5, 2025 at 4:02 PM
Another great preprint out from the Hernando lab, lead by Maria Gomez and Allie Kartz. Did you know that melanoma brain metastasis upregulate the carnosine dipeptidase CNDP1 through MITF to prevent intracellular copper accumulation?
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature Communications
Super-enhancers (SEs) drive specific gene expression programmes underlying different cancer cell states offering opportunities for therapeutic targeting. Here, the authors suggest targeting SE-depende...
www.nature.com
January 9, 2025 at 2:33 AM
Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pietro Berico
Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon
🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics
Single-cell mapping of regulatory DNA:Protein interactions
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...
biorxiv.org
January 2, 2025 at 9:54 PM
Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon
If you are looking for an holiday read, check out our new story on how HOXD13 promotes melanoma growth! Others stories are coming soon thanks to my mentor and partner in crime Eva Hernando at @nyulangonepccsm.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A targetable developmental program co-regulates angiogenesis and immune evasion
Ultraviolet (UV)-induced DNA mutations produce genetic drivers of cutaneous melanoma initiation and numerous neoantigens that can trigger anti-tumor immune responses in the host. Consequently, melanom...
www.biorxiv.org
December 22, 2024 at 1:10 PM
If you are looking for an holiday read, check out our new story on how HOXD13 promotes melanoma growth! Others stories are coming soon thanks to my mentor and partner in crime Eva Hernando at @nyulangonepccsm.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pietro Berico
We just posted a preprint about a death mechanism that we find truly surprising.
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
Pol II degradation activates cell death independently from the loss of transcription
Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here,...
www.biorxiv.org
December 13, 2024 at 2:17 PM
We just posted a preprint about a death mechanism that we find truly surprising.
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
When you turn off transcription, cells die (duh!)... but did you know this happens due to loss of Pol II itself, not loss of Pol II activity!?!
preprint here and a thread (1/n): www.biorxiv.org/content/10.1...
🧪
Reposted by Pietro Berico
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements - Nature Genetics
ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...
www.nature.com
November 27, 2024 at 4:13 AM
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pietro Berico
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...
www.cell.com
November 14, 2024 at 4:02 PM
Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it"
www.cell.com/action/showP...
www.cell.com/action/showP...