Laboratory of Chemical and Biological Probes
@locbp.bsky.social
Working at the interface of chemistry and biology at the University of Zurich. PI: Pablo Rivera-Fuentes
Reposted by Laboratory of Chemical and Biological Probes
They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...
November 6, 2025 at 8:30 AM
They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...
We are hiring! Excited about redox chemical biology? Help us discover what controls the redox state of the Golgi apparatus. Also, please help us spread the word by reposting this ad. Apply here: jobs.uzh.ch/job-vacancie...
UZH: PhD Position in Redox Chemical Biology
We are a dynamic, interdisciplinary, medium-size lab working at the interface of chemistry and biology. We work on the development of probes to visualize and control biological processes in living sys...
jobs.uzh.ch
October 31, 2025 at 4:36 PM
We are hiring! Excited about redox chemical biology? Help us discover what controls the redox state of the Golgi apparatus. Also, please help us spread the word by reposting this ad. Apply here: jobs.uzh.ch/job-vacancie...
Reposted by Laboratory of Chemical and Biological Probes
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry
Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...
www.nature.com
October 30, 2025 at 10:27 AM
How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)
www.nature.com/articles/s41...
Congratulations to Doro for another presentation prize! This time for her talk at SCF ChemBio in Paris.
🎉 Congratulations to the winners of the Best Trainee Communications Prizes at the #ICBS trainee symposium, held at the start of #ChemBioParis2025 !
Hayoung Son - Seoul National University
Mikkel Nielsen - Aarhus University
Dorothea Kossmann - University of Zurich
#ChemBio #ChemSky
📸Fabien Venturi
Hayoung Son - Seoul National University
Mikkel Nielsen - Aarhus University
Dorothea Kossmann - University of Zurich
#ChemBio #ChemSky
📸Fabien Venturi
October 15, 2025 at 10:42 AM
Congratulations to Doro for another presentation prize! This time for her talk at SCF ChemBio in Paris.
Reposted by Laboratory of Chemical and Biological Probes
The @locbp.bsky.social @chem.uzh.ch developed a gene expression reporter system based on the coexpression of the protein of interest BiP/GRP78 and the reporter HaloTag. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
October 8, 2025 at 11:47 AM
The @locbp.bsky.social @chem.uzh.ch developed a gene expression reporter system based on the coexpression of the protein of interest BiP/GRP78 and the reporter HaloTag. chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Congratulations to Hen (again)! Her paper, in collaboration with Jade, Juan, and the EPFL ACCESS team was just published. The paper describes a chemigenetic gene reporter tool for time-stamping and pulse-chase-type experiments.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Two‐Color Timestamping of Gene Expression with a Chemigenetic Reporter System
A chemigenetic reporter assay is developed that enables monitoring of BiP/GRP78 expression, an important chaperone and key regulator of the unfolded protein response. The system is based on the coexp....
chemistry-europe.onlinelibrary.wiley.com
September 15, 2025 at 7:54 AM
Congratulations to Hen (again)! Her paper, in collaboration with Jade, Juan, and the EPFL ACCESS team was just published. The paper describes a chemigenetic gene reporter tool for time-stamping and pulse-chase-type experiments.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Congratulation's to Hen! Great job presenting her chemigenetic gene expression reporter system!
Congratulations to all the Poster Presentation Awardees @chem.uzh.ch at the SCS Fall Meeting: Noah Rychener 👏, Vincent Freiburghaus 👏, Henriette Lämmermann 👏, Fan Liu 👏, Nanchen Dongfang 👏 and Shangkun Li 👏
September 12, 2025 at 2:03 PM
Congratulation's to Hen! Great job presenting her chemigenetic gene expression reporter system!
Congrats to Juan! His discovery of hemicyanines as potent activators of paraptotic cell death has just been published! With great contributions from Jade (initial observations of ER swelling) and Craig (crucial supporting experiments)!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Potent Inducers of Paraptosis through Electronic Tuning of Hemicyanine Electrophiles
Paraptosis is a distinct form of programmed cell death characterized by cytoplasmic vacuolization, mitochondrial swelling, and endoplasmic reticulum (ER) dilation, offering an alternative to apoptosis...
pubs.acs.org
August 26, 2025 at 10:15 AM
Congrats to Juan! His discovery of hemicyanines as potent activators of paraptotic cell death has just been published! With great contributions from Jade (initial observations of ER swelling) and Craig (crucial supporting experiments)!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Happy to share the results of a fun side project in which we used the COUPY dye and mutants of HaloTag7 to show that changes in fluorescence lifetime correlate with the polarity of the protein binding pocket!
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
#FLIM #fluorescence #HaloTag
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
#FLIM #fluorescence #HaloTag
Fluorescence Lifetime Multiplexing with Environment‐Sensitive Chemigenetic Probes
HaloTag (HT) is a versatile self-labeling protein that has been widely adopted in fluorescence microscopy. Besides its established use as an intensity-based marker and sensor, interest in using HT fo....
chemistry-europe.onlinelibrary.wiley.com
April 30, 2025 at 12:10 PM
Happy to share the results of a fun side project in which we used the COUPY dye and mutants of HaloTag7 to show that changes in fluorescence lifetime correlate with the polarity of the protein binding pocket!
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
#FLIM #fluorescence #HaloTag
chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1...
#FLIM #fluorescence #HaloTag
🚨Open PhD positions in chemical biology!🚨
Join us in developing chemigenetic probes for imaging and sensing.
⚗️🧫Experience in chemical synthesis and/or protein engineering?
🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment?
Apply (or re-post)!
jobs.uzh.ch/job-vacancie...
Join us in developing chemigenetic probes for imaging and sensing.
⚗️🧫Experience in chemical synthesis and/or protein engineering?
🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment?
Apply (or re-post)!
jobs.uzh.ch/job-vacancie...
UZH: PhD position in Chemical Biology
In the Laboratory of Chemical and Biological probes (PI: Pablo Rivera Fuentes), we do research at the interface of chemistry and biology, particularly in the fields of redox biology, development of im...
jobs.uzh.ch
April 7, 2025 at 6:28 AM
🚨Open PhD positions in chemical biology!🚨
Join us in developing chemigenetic probes for imaging and sensing.
⚗️🧫Experience in chemical synthesis and/or protein engineering?
🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment?
Apply (or re-post)!
jobs.uzh.ch/job-vacancie...
Join us in developing chemigenetic probes for imaging and sensing.
⚗️🧫Experience in chemical synthesis and/or protein engineering?
🗻🇨🇭Love mountains, chocolate, and a safe, diverse, and engaging environment?
Apply (or re-post)!
jobs.uzh.ch/job-vacancie...
Reposted by Laboratory of Chemical and Biological Probes
🚨 PhD Opportunity!
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
March 17, 2025 at 10:41 AM
🚨 PhD Opportunity!
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
Passionate about enzyme engineering or genetic code expansion? 🧬 Our lab is hiring a PhD student!
🔬 Exciting interdisciplinary research
🤝 Engaging environment 🌱
📄 Does this sound like you, apply now! ⏳🔗
📢 Know someone? Share this! 🔄
jobs.uzh.ch/job-vacancie...
Reposted by Laboratory of Chemical and Biological Probes
Looking for a PhD candidate to join my group at the University of Zurich If you are an excellent and motivated student🧑🔬and want to integrate organic synthesis, photochemistry and redox chemistry in a research🧪 we want to know more about you! More info: www.stacko.group Appreciate sharing the post.
February 25, 2025 at 8:22 AM
Looking for a PhD candidate to join my group at the University of Zurich If you are an excellent and motivated student🧑🔬and want to integrate organic synthesis, photochemistry and redox chemistry in a research🧪 we want to know more about you! More info: www.stacko.group Appreciate sharing the post.
Now online at a peer-reviewed journal, Carla's careful characterization of the redox state of glutathione in the Golgi apparatus: www.sciencedirect.com/science/arti...
Characterization of the Glutathione Redox State in the Golgi Apparatus
Redox homeostasis is crucial for cell function, and, in eukaryotic cells, studying it in a compartmentalized way is essential due to the redox variati…
www.sciencedirect.com
February 20, 2025 at 2:24 PM
Now online at a peer-reviewed journal, Carla's careful characterization of the redox state of glutathione in the Golgi apparatus: www.sciencedirect.com/science/arti...
Reposted by Laboratory of Chemical and Biological Probes
Exciting news from the lab! Our first preprint, “Hydrophobic Tuning with Non-Canonical Amino Acids in a Copper Metalloenzyme” is now available.
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
Hydrophobic tuning with non-canonical amino acids in a copper metalloenzyme
Hydrophobicity controls many aspects of protein and enzyme function. Although hydrophobic tuning can be achieved to a limited extent with canonical amino acids, the incorporation of non- canonical ami...
www.biorxiv.org
February 11, 2025 at 9:28 AM
Exciting news from the lab! Our first preprint, “Hydrophobic Tuning with Non-Canonical Amino Acids in a Copper Metalloenzyme” is now available.
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
In this study, we rewrite the rules of enzyme engineering with a cyclic, hydrophobic twist that’s anything but ordinary.
🔍: www.biorxiv.org/content/10.1...
Congratulations to @puentene.bsky.social, who won the best poster award at #SMPS24 @smps4.bsky.social!!
January 27, 2025 at 9:28 AM
Congratulations to @puentene.bsky.social, who won the best poster award at #SMPS24 @smps4.bsky.social!!
Reposted by Laboratory of Chemical and Biological Probes
Another brilliant session by Pablo Rivera-Fuentes from the University of Zurich on 'Single-Molecule Protein Identification using Blinking Patterns.'
#SMPS4
#SMPS4
January 23, 2025 at 12:48 PM
Another brilliant session by Pablo Rivera-Fuentes from the University of Zurich on 'Single-Molecule Protein Identification using Blinking Patterns.'
#SMPS4
#SMPS4
Just out on bioRxiv, Carla Miró reports the first quantitative determination of the redox state of glutathione in the Golgi apparatus. Spoiler alert: it is very oxidized and in relatively low concentrations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Characterization of the Glutathione Redox State in the Golgi Apparatus
Redox homeostasis is crucial for cell function, and, in eukaryotic cells, studying it in a compartmentalized way is essential due to the redox variations between different organelles. The redox state ...
www.biorxiv.org
December 9, 2024 at 6:44 AM
Just out on bioRxiv, Carla Miró reports the first quantitative determination of the redox state of glutathione in the Golgi apparatus. Spoiler alert: it is very oxidized and in relatively low concentrations!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Long overdue, we have left the propaganda machine formerly known as Twitter and will be posting exclusively here!
November 13, 2024 at 6:24 AM
Long overdue, we have left the propaganda machine formerly known as Twitter and will be posting exclusively here!