LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group
@ljrusselllab.bsky.social
Russell Lab | NUCancer | Newcastle University
https://www.ncl.ac.uk/medical-sciences/people/profile/lisarussell.html
https://www.ncl.ac.uk/medical-sciences/people/profile/lisarussell.html
Pinned
Beyond the genome: Harnessing the power of super-enhancers for blood cancer - Cancer Research UK - Cancer News
The mysteries of the epiregulome need to be tackled head-on if we are to get new precision treatments for blood cancers
news.cancerresearchuk.org
Lisa Russell just wrote an insightful article for #CancerNews from @cancerresearchuk.org where she takes us through the promise of super-enhancer biology and what it means for cancer. Read the whole article here:
news.cancerresearchuk.org/2025/05/21/b...
news.cancerresearchuk.org/2025/05/21/b...
I was welcomed to the lab meeting yesterday by this spooky bunch 🤪. Always up for a giggle and certainly made my day 😆
November 1, 2025 at 10:15 PM
I was welcomed to the lab meeting yesterday by this spooky bunch 🤪. Always up for a giggle and certainly made my day 😆
Viruses effectively deliver gene-editing proteins into leukaemia cells. Envelope proteins ‘coat’ the virus, and the best envelope choice can vary between different leukaemias. We use fluorescent dyes to decide which envelope will allow the best delivery of the gene-editing proteins to the cells.
October 13, 2025 at 1:51 PM
Viruses effectively deliver gene-editing proteins into leukaemia cells. Envelope proteins ‘coat’ the virus, and the best envelope choice can vary between different leukaemias. We use fluorescent dyes to decide which envelope will allow the best delivery of the gene-editing proteins to the cells.
We’re proud to share the inspiring story of Dr. Dan Mattison — diagnosed with leukaemia at age 14, and now a Foundation Year 2 doctor. Dan and his family are welcoming a £4.1 million investment from @cancerresearchuk.org. Read more here: www.ncl.ac.uk/press/articl...
Alumnus who survived teenage cancer welcomes multi-million funding
A Newcastle University graduate who survived cancer as a teen and was inspired to become a doctor by those who cared for him, is welcoming a multi-million pound investment from Cancer Research UK.
www.ncl.ac.uk
September 30, 2025 at 7:17 AM
We’re proud to share the inspiring story of Dr. Dan Mattison — diagnosed with leukaemia at age 14, and now a Foundation Year 2 doctor. Dan and his family are welcoming a £4.1 million investment from @cancerresearchuk.org. Read more here: www.ncl.ac.uk/press/articl...
Last week on #WorldCancerResearchDay the whole lab and other colleagues from @nucancer.bsky.social turned into bakers to help fundraising for @cancerresearchuk.org, a charity close to us for their commitment to fund groundbreaking projects in cancer research. Lovely seeing the public engaged!
September 28, 2025 at 1:20 PM
Last week on #WorldCancerResearchDay the whole lab and other colleagues from @nucancer.bsky.social turned into bakers to help fundraising for @cancerresearchuk.org, a charity close to us for their commitment to fund groundbreaking projects in cancer research. Lovely seeing the public engaged!
September is #ChildhoodCancerAwarenessMonth. Our team joined the @childcancernth.bsky.social campaign #PaintTheToonGold to show support for children with cancer and their families. Together, we can raise awareness and keep pushing research forward.
September 19, 2025 at 4:35 PM
September is #ChildhoodCancerAwarenessMonth. Our team joined the @childcancernth.bsky.social campaign #PaintTheToonGold to show support for children with cancer and their families. Together, we can raise awareness and keep pushing research forward.
We were excited to share our recent research findings and projects at #CLRUK25 in York. Dr. Brittain and Dr. Alqahtani were thrilled to present their projects, supported by @cancerresearchuk.org and @bloodcanceruk.bsky.social. Dr. Marchetti brought great energy while chairing the first session.
September 12, 2025 at 3:44 PM
We were excited to share our recent research findings and projects at #CLRUK25 in York. Dr. Brittain and Dr. Alqahtani were thrilled to present their projects, supported by @cancerresearchuk.org and @bloodcanceruk.bsky.social. Dr. Marchetti brought great energy while chairing the first session.
Morning coffee and train for the whole lab today, direction #CLRUK25 in York! Looking forward to seeing everyone from the CLR-UK network! #ChildhoodCancerAwarenessMonth #BloodCancerAwarenessMonth
September 11, 2025 at 8:28 AM
Morning coffee and train for the whole lab today, direction #CLRUK25 in York! Looking forward to seeing everyone from the CLR-UK network! #ChildhoodCancerAwarenessMonth #BloodCancerAwarenessMonth
Research is not a solo effort.
It takes teamwork. It takes belief. It takes collaboration.
We know what it takes to beat blood cancer and so does @dr-ahlamq.bsky.social whose work is funded by @bloodcanceruk.bsky.social grant co-led by Lisa & @letimarchetti.bsky.social
#BloodCancerAwarenessMonth
It takes teamwork. It takes belief. It takes collaboration.
We know what it takes to beat blood cancer and so does @dr-ahlamq.bsky.social whose work is funded by @bloodcanceruk.bsky.social grant co-led by Lisa & @letimarchetti.bsky.social
#BloodCancerAwarenessMonth
September 4, 2025 at 8:23 AM
Research is not a solo effort.
It takes teamwork. It takes belief. It takes collaboration.
We know what it takes to beat blood cancer and so does @dr-ahlamq.bsky.social whose work is funded by @bloodcanceruk.bsky.social grant co-led by Lisa & @letimarchetti.bsky.social
#BloodCancerAwarenessMonth
It takes teamwork. It takes belief. It takes collaboration.
We know what it takes to beat blood cancer and so does @dr-ahlamq.bsky.social whose work is funded by @bloodcanceruk.bsky.social grant co-led by Lisa & @letimarchetti.bsky.social
#BloodCancerAwarenessMonth
We recently welcomed Dr Nicholas Brittain to the
LEGEND group, who has joined as a Research
Associate to investigate mechanisms driving
super-enhancers in paediatric leukaemia as part
of a research project funded by @cancerresearchuk.org
LEGEND group, who has joined as a Research
Associate to investigate mechanisms driving
super-enhancers in paediatric leukaemia as part
of a research project funded by @cancerresearchuk.org
August 8, 2025 at 2:58 PM
We recently welcomed Dr Nicholas Brittain to the
LEGEND group, who has joined as a Research
Associate to investigate mechanisms driving
super-enhancers in paediatric leukaemia as part
of a research project funded by @cancerresearchuk.org
LEGEND group, who has joined as a Research
Associate to investigate mechanisms driving
super-enhancers in paediatric leukaemia as part
of a research project funded by @cancerresearchuk.org
Recent nice weather called for a social outing of the LEGEND group, filled with fun, sport and a MUST stop for ice cream by the coast 🍦. We also had our first lab retreat at Cockle Park, featuring good scientific discussion 🧬 and a
visit by our @ukri.org MRC collaborators from Edinburgh ✨
visit by our @ukri.org MRC collaborators from Edinburgh ✨
August 8, 2025 at 8:05 AM
Recent nice weather called for a social outing of the LEGEND group, filled with fun, sport and a MUST stop for ice cream by the coast 🍦. We also had our first lab retreat at Cockle Park, featuring good scientific discussion 🧬 and a
visit by our @ukri.org MRC collaborators from Edinburgh ✨
visit by our @ukri.org MRC collaborators from Edinburgh ✨
Thrilled to have contributed to ground-breaking research led by Dr Joan Boyes (@universityofleeds.bsky.social), just out in Nature (@nature.com)! 🧬 We show that tiny DNA fragments, naturally cut from the genome, can linger—causing more damage & helping leukaemia progress.
August 7, 2025 at 8:31 AM
Thrilled to have contributed to ground-breaking research led by Dr Joan Boyes (@universityofleeds.bsky.social), just out in Nature (@nature.com)! 🧬 We show that tiny DNA fragments, naturally cut from the genome, can linger—causing more damage & helping leukaemia progress.
Our lab was delighted to host a visit from @cancerresearchuk.org fundraisers, campaigners, and patient advocates Sue Duncombe and Patrick McGuire. It was a pleasure to share our research, to give an insight into our daily work and highlight how CRUK support helps us move science forward.
July 8, 2025 at 3:30 PM
Our lab was delighted to host a visit from @cancerresearchuk.org fundraisers, campaigners, and patient advocates Sue Duncombe and Patrick McGuire. It was a pleasure to share our research, to give an insight into our daily work and highlight how CRUK support helps us move science forward.
Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group
🌟 Nominate Children’s Cancer North for a chance to win £5,000!
The Benefact Movement for Good Health & Wellbeing Special Draw is open until May 4. By nominating us, Children’s Cancer North could win £5,000 to help make life better for children and young people affected by cancer
👉 loom.ly/dFhKtac
The Benefact Movement for Good Health & Wellbeing Special Draw is open until May 4. By nominating us, Children’s Cancer North could win £5,000 to help make life better for children and young people affected by cancer
👉 loom.ly/dFhKtac
Nominate a charity - Movement for Good
Nominate a charity for a Movement for Good award now.
loom.ly
April 28, 2025 at 11:27 AM
🌟 Nominate Children’s Cancer North for a chance to win £5,000!
The Benefact Movement for Good Health & Wellbeing Special Draw is open until May 4. By nominating us, Children’s Cancer North could win £5,000 to help make life better for children and young people affected by cancer
👉 loom.ly/dFhKtac
The Benefact Movement for Good Health & Wellbeing Special Draw is open until May 4. By nominating us, Children’s Cancer North could win £5,000 to help make life better for children and young people affected by cancer
👉 loom.ly/dFhKtac
Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group
We are hiring! Great opportunity for a RA with bioinformatic skills
We are looking for talented researcher to work on a project to detect gene fusions and driver mutations in a large cohort of children with ALL treated across multiple different trials to determine their clinical relevance.
We are looking for talented researcher to work on a project to detect gene fusions and driver mutations in a large cohort of children with ALL treated across multiple different trials to determine their clinical relevance.
Research Assistant/Associate in Cancer Genomics
Research Assistant/Associate in Cancer Genomics
jobs.ncl.ac.uk
June 27, 2025 at 6:46 AM
We are hiring! Great opportunity for a RA with bioinformatic skills
We are looking for talented researcher to work on a project to detect gene fusions and driver mutations in a large cohort of children with ALL treated across multiple different trials to determine their clinical relevance.
We are looking for talented researcher to work on a project to detect gene fusions and driver mutations in a large cohort of children with ALL treated across multiple different trials to determine their clinical relevance.
Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group
Having a great day with the whole @ljrusselllab.bsky.social group, attending the @nucancer.bsky.social 2025 conference, showcasing excellent research from across the faculty, including some of our own from the #WolfsonCentre in the Herschel building, Alistair Poll and Melvin Joy. More to come later!
June 10, 2025 at 1:38 PM
Having a great day with the whole @ljrusselllab.bsky.social group, attending the @nucancer.bsky.social 2025 conference, showcasing excellent research from across the faculty, including some of our own from the #WolfsonCentre in the Herschel building, Alistair Poll and Melvin Joy. More to come later!
Reposted by LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group
@ljrusselllab.bsky.social has crafted beautiful items for Children's Cancer North!
If you want to help this amazing charity, have a look at the shop :
Lunch Bag: shorturl.at/jvdLm
Phone Holder: shorturl.at/QbFXN
Pouch: shorturl.at/ryX6x
If you want to help this amazing charity, have a look at the shop :
Lunch Bag: shorturl.at/jvdLm
Phone Holder: shorturl.at/QbFXN
Pouch: shorturl.at/ryX6x
CCN Lunch Bag - Children's Cancer North
With this CCN lunch bag, you’re not only getting a beautifully hand-crafted accessory but also helping fund vital research and support children with cancer
childrenscancernorth.org.uk
June 11, 2025 at 1:46 PM
@ljrusselllab.bsky.social has crafted beautiful items for Children's Cancer North!
If you want to help this amazing charity, have a look at the shop :
Lunch Bag: shorturl.at/jvdLm
Phone Holder: shorturl.at/QbFXN
Pouch: shorturl.at/ryX6x
If you want to help this amazing charity, have a look at the shop :
Lunch Bag: shorturl.at/jvdLm
Phone Holder: shorturl.at/QbFXN
Pouch: shorturl.at/ryX6x
Great poster session by the LEGEND team. Lots of informative discussions had with other @nucancer.bsky.social colleagues.
June 10, 2025 at 3:16 PM
Great poster session by the LEGEND team. Lots of informative discussions had with other @nucancer.bsky.social colleagues.
Great morning had at the @nucancer.bsky.social conference. Proud to see the work of the team presented as recent success stories coming from the centre.
June 10, 2025 at 11:51 AM
Great morning had at the @nucancer.bsky.social conference. Proud to see the work of the team presented as recent success stories coming from the centre.
First time running a "Meet the Expert" session today at the European School for Haematology. Despite being nervous and not really knowing what to expect, I thoroughly enjoyed myself. I had a lovely group of attendees who made the experience one to remember.
May 23, 2025 at 4:31 PM
First time running a "Meet the Expert" session today at the European School for Haematology. Despite being nervous and not really knowing what to expect, I thoroughly enjoyed myself. I had a lovely group of attendees who made the experience one to remember.
Privileged to have been asked to speak at this years ESH conference on acute lymphoblastic leukaemia in beautiful Malahide, Dublin. Great opportunity for extensive discussion and new collaborations.
May 23, 2025 at 4:23 PM
Privileged to have been asked to speak at this years ESH conference on acute lymphoblastic leukaemia in beautiful Malahide, Dublin. Great opportunity for extensive discussion and new collaborations.
Lisa Russell just wrote an insightful article for #CancerNews from @cancerresearchuk.org where she takes us through the promise of super-enhancer biology and what it means for cancer. Read the whole article here:
news.cancerresearchuk.org/2025/05/21/b...
news.cancerresearchuk.org/2025/05/21/b...
Beyond the genome: Harnessing the power of super-enhancers for blood cancer - Cancer Research UK - Cancer News
The mysteries of the epiregulome need to be tackled head-on if we are to get new precision treatments for blood cancers
news.cancerresearchuk.org
May 22, 2025 at 1:51 PM
Lisa Russell just wrote an insightful article for #CancerNews from @cancerresearchuk.org where she takes us through the promise of super-enhancer biology and what it means for cancer. Read the whole article here:
news.cancerresearchuk.org/2025/05/21/b...
news.cancerresearchuk.org/2025/05/21/b...
Well done to all the Wolfson Childhood Cancer Research Centre runners for completing the #ChildrensCancerRun today at Gosforth Park. @childcancernth.bsky.social @newcastleuni.bsky.social
May 18, 2025 at 7:24 PM
Well done to all the Wolfson Childhood Cancer Research Centre runners for completing the #ChildrensCancerRun today at Gosforth Park. @childcancernth.bsky.social @newcastleuni.bsky.social
Great day at the #ChildrensCancerRun inspiring young minds and raising money to support families through a cancer diagnosis and to fund vital cancer research here in the North East @childcancernth.bsky.social
May 18, 2025 at 1:44 PM
Great day at the #ChildrensCancerRun inspiring young minds and raising money to support families through a cancer diagnosis and to fund vital cancer research here in the North East @childcancernth.bsky.social
Had a great time at SIOPE meeting this week. Hearing the latest research on the biology and diagnosis of childhood leukaemia. Also had the privilege of seeing my PhD supervisor being awarded a Lifetime Achievement Award for her contribution to the field.
May 17, 2025 at 8:31 PM
Had a great time at SIOPE meeting this week. Hearing the latest research on the biology and diagnosis of childhood leukaemia. Also had the privilege of seeing my PhD supervisor being awarded a Lifetime Achievement Award for her contribution to the field.
Our lab was delighted to host a lab tour for the fantastic team from @teleperformance-gp.bsky.social We were happy to showcase our expertise in cell culture(Leti&Cami), gene editing (Ahlam&Ahmed) and data analysis (Phoebe). Thanks for sponsoring the Business Beats Cancer North East.
May 2, 2025 at 3:54 PM
Our lab was delighted to host a lab tour for the fantastic team from @teleperformance-gp.bsky.social We were happy to showcase our expertise in cell culture(Leti&Cami), gene editing (Ahlam&Ahmed) and data analysis (Phoebe). Thanks for sponsoring the Business Beats Cancer North East.