Longo Lab @ ELSI
@liamlongo.bsky.social
Protein Historian
Specially Appointed Associate Professor at the Earth-Life Science Institute, Institute of Science Tokyo
Affiliate Research Scientist at the Blue Marble Space Institute of Science
My academic journey: 🇺🇸 → 🇮🇱 → 🇯🇵
Specially Appointed Associate Professor at the Earth-Life Science Institute, Institute of Science Tokyo
Affiliate Research Scientist at the Blue Marble Space Institute of Science
My academic journey: 🇺🇸 → 🇮🇱 → 🇯🇵
Reposted by Longo Lab @ ELSI
Exploring the role of short peptide motifs (focusing on Walker A P-loop) at the origins of life using simulations. Discussion of collaborative work with the @liamlongo.bsky.social and other colleagues. What can molecular fossils teach us about the first proteins? theconversation.com/molecular-fo...
Molecular ‘fossils’ offer microscopic clues to the origins of life – but they take care to interpret
A protein historian and evolutionary biochemist found that a protein sequence present across all known life didn’t form as researchers previously thought it did.
theconversation.com
September 16, 2025 at 3:18 PM
Exploring the role of short peptide motifs (focusing on Walker A P-loop) at the origins of life using simulations. Discussion of collaborative work with the @liamlongo.bsky.social and other colleagues. What can molecular fossils teach us about the first proteins? theconversation.com/molecular-fo...
Representation shapes the questions we ask. Here, we use contrastive learning to unite sequence and structure and build a new, global "map" of protein space.
Preprint: www.biorxiv.org/content/10.1...
Congratulations to Guy Yanai, who led this work, Rachel Kolodny, Nir Ben Tal, and Gabriel Axel
Preprint: www.biorxiv.org/content/10.1...
Congratulations to Guy Yanai, who led this work, Rachel Kolodny, Nir Ben Tal, and Gabriel Axel
September 8, 2025 at 8:14 PM
Representation shapes the questions we ask. Here, we use contrastive learning to unite sequence and structure and build a new, global "map" of protein space.
Preprint: www.biorxiv.org/content/10.1...
Congratulations to Guy Yanai, who led this work, Rachel Kolodny, Nir Ben Tal, and Gabriel Axel
Preprint: www.biorxiv.org/content/10.1...
Congratulations to Guy Yanai, who led this work, Rachel Kolodny, Nir Ben Tal, and Gabriel Axel
Is phylogenetics the only record of protein history? No!
Led by Tatsuya Corlett, we show that the history of enzymes is written into the structure of metabolism. From there, we reconstruct a self-consistent model of metabolic and enzyme evolution.
www.biorxiv.org/content/10.1...
Led by Tatsuya Corlett, we show that the history of enzymes is written into the structure of metabolism. From there, we reconstruct a self-consistent model of metabolic and enzyme evolution.
www.biorxiv.org/content/10.1...
The History of Enzyme Evolution Embedded in Metabolism
Phylogenetic reconstructions are a primary record of protein evolution. But what other records can attest to the deep history of enzymes, and what tools are needed to decode their meaning? Here, we de...
www.biorxiv.org
July 21, 2025 at 2:09 PM
Is phylogenetics the only record of protein history? No!
Led by Tatsuya Corlett, we show that the history of enzymes is written into the structure of metabolism. From there, we reconstruct a self-consistent model of metabolic and enzyme evolution.
www.biorxiv.org/content/10.1...
Led by Tatsuya Corlett, we show that the history of enzymes is written into the structure of metabolism. From there, we reconstruct a self-consistent model of metabolic and enzyme evolution.
www.biorxiv.org/content/10.1...
Reposted by Longo Lab @ ELSI
"Protein Problem: Georgia Tech Researchers Challenge Fundamental Assumption in Evolutionary Biochemistry", GT press release on our latest paper with @liamlongo.bsky.social and colleagues. research.gatech.edu/protein-prob...
Protein Problem: Georgia Tech Researchers Challenge Fundamental Assumption in Evolutionary Biochemistry | Research
How did life originate? Ancient proteins may hold the clues. Every organism on Earth is made up of proteins. Although all organisms — even single-celled ones —have complex protein structures now, this...
research.gatech.edu
May 1, 2025 at 7:37 PM
"Protein Problem: Georgia Tech Researchers Challenge Fundamental Assumption in Evolutionary Biochemistry", GT press release on our latest paper with @liamlongo.bsky.social and colleagues. research.gatech.edu/protein-prob...
Excited to announce that @preinerin.bsky.social, @colemathis.bsky.social and I were awarded an @hfspo.bsky.social research grant! 🎉
If you are an experimentalist interested in studying protein histories as a graduate student in the Longo Lab ELSI, please get in touch.
If you are an experimentalist interested in studying protein histories as a graduate student in the Longo Lab ELSI, please get in touch.
March 30, 2025 at 7:05 AM
Excited to announce that @preinerin.bsky.social, @colemathis.bsky.social and I were awarded an @hfspo.bsky.social research grant! 🎉
If you are an experimentalist interested in studying protein histories as a graduate student in the Longo Lab ELSI, please get in touch.
If you are an experimentalist interested in studying protein histories as a graduate student in the Longo Lab ELSI, please get in touch.
Reposted by Longo Lab @ ELSI
Our ambidextrous HhH peptide is now in @angewandtechemie.bsky.social
Proud of the great team @liamlongo.bsky.social , Metanis lab and Koby Levy lab
Proud of the great team @liamlongo.bsky.social , Metanis lab and Koby Levy lab
Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain
Now out now in @angewandtechemie.bsky.social
Exciting collaboration with Norman Metanis and Koby Levy
onlinelibrary.wiley.com/doi/10.1002/...
Now out now in @angewandtechemie.bsky.social
Exciting collaboration with Norman Metanis and Koby Levy
onlinelibrary.wiley.com/doi/10.1002/...
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain
The helix-hairpin-helix (HhH) motif is an ancient and ubiquitous nucleic acid-binding element that has emerged as a model system for studying the evolution of dsDNA-binding domains from simple peptid....
onlinelibrary.wiley.com
March 29, 2025 at 4:22 AM
Our ambidextrous HhH peptide is now in @angewandtechemie.bsky.social
Proud of the great team @liamlongo.bsky.social , Metanis lab and Koby Levy lab
Proud of the great team @liamlongo.bsky.social , Metanis lab and Koby Levy lab
Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases
Now out in Molecular Biology and Evolution
Exciting collaboration with @lynnkamerlin.bsky.social
academic.oup.com/mbe/advance-...
Now out in Molecular Biology and Evolution
Exciting collaboration with @lynnkamerlin.bsky.social
academic.oup.com/mbe/advance-...
Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases
Abstract. At the heart of many nucleoside triphosphatases is a conserved phosphate-binding sequence motif. A current model of early enzyme evolution propos
academic.oup.com
March 28, 2025 at 4:10 PM
Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases
Now out in Molecular Biology and Evolution
Exciting collaboration with @lynnkamerlin.bsky.social
academic.oup.com/mbe/advance-...
Now out in Molecular Biology and Evolution
Exciting collaboration with @lynnkamerlin.bsky.social
academic.oup.com/mbe/advance-...
Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain
Now out now in @angewandtechemie.bsky.social
Exciting collaboration with Norman Metanis and Koby Levy
onlinelibrary.wiley.com/doi/10.1002/...
Now out now in @angewandtechemie.bsky.social
Exciting collaboration with Norman Metanis and Koby Levy
onlinelibrary.wiley.com/doi/10.1002/...
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain
The helix-hairpin-helix (HhH) motif is an ancient and ubiquitous nucleic acid-binding element that has emerged as a model system for studying the evolution of dsDNA-binding domains from simple peptid....
onlinelibrary.wiley.com
March 28, 2025 at 4:02 PM
Functional Ambidexterity of an Ancient Nucleic Acid-Binding Domain
Now out now in @angewandtechemie.bsky.social
Exciting collaboration with Norman Metanis and Koby Levy
onlinelibrary.wiley.com/doi/10.1002/...
Now out now in @angewandtechemie.bsky.social
Exciting collaboration with Norman Metanis and Koby Levy
onlinelibrary.wiley.com/doi/10.1002/...
Need phosphorylating power? Maybe our universal polyphosphate kinase can help!
ATP ✅ GTP ✅ CTP ✅ UTP ✅
in vitro transcription ✅
An energizing collaboration with the Matsuura Group @ ELSI. Check out the preprint here👇
www.biorxiv.org/content/10.1...
ATP ✅ GTP ✅ CTP ✅ UTP ✅
in vitro transcription ✅
An energizing collaboration with the Matsuura Group @ ELSI. Check out the preprint here👇
www.biorxiv.org/content/10.1...
A universal polyphosphate kinase powers in vitro transcription
Polyphosphate kinases (PPKs) catalyze phosphoryl transfer between polyphosphates and nucleotides. Polyphosphates are a cost-effective source of phosphorylating power, making polyphosphate kinases an a...
www.biorxiv.org
March 26, 2025 at 6:47 AM
Need phosphorylating power? Maybe our universal polyphosphate kinase can help!
ATP ✅ GTP ✅ CTP ✅ UTP ✅
in vitro transcription ✅
An energizing collaboration with the Matsuura Group @ ELSI. Check out the preprint here👇
www.biorxiv.org/content/10.1...
ATP ✅ GTP ✅ CTP ✅ UTP ✅
in vitro transcription ✅
An energizing collaboration with the Matsuura Group @ ELSI. Check out the preprint here👇
www.biorxiv.org/content/10.1...