Leander Goldbach
@lgoldbach.bsky.social
Ph.D. student @ Wagner Lab - University of Zürich
Reposted by Leander Goldbach
Hello Bluesky!
Does Nₑ really explain mutation rate (μ) or genome size (GS) in vertebrates?
We find the apparent Nₑ–μ link in Bergeron et al. (2023) is a “back-door” path via generation time, and GS is decoupled from both Nₑ and life-history traits.
www.pnas.org/doi/10.1073/...
#evobio #PNAS
Does Nₑ really explain mutation rate (μ) or genome size (GS) in vertebrates?
We find the apparent Nₑ–μ link in Bergeron et al. (2023) is a “back-door” path via generation time, and GS is decoupled from both Nₑ and life-history traits.
www.pnas.org/doi/10.1073/...
#evobio #PNAS
February 7, 2026 at 9:23 PM
Hello Bluesky!
Does Nₑ really explain mutation rate (μ) or genome size (GS) in vertebrates?
We find the apparent Nₑ–μ link in Bergeron et al. (2023) is a “back-door” path via generation time, and GS is decoupled from both Nₑ and life-history traits.
www.pnas.org/doi/10.1073/...
#evobio #PNAS
Does Nₑ really explain mutation rate (μ) or genome size (GS) in vertebrates?
We find the apparent Nₑ–μ link in Bergeron et al. (2023) is a “back-door” path via generation time, and GS is decoupled from both Nₑ and life-history traits.
www.pnas.org/doi/10.1073/...
#evobio #PNAS
Reposted by Leander Goldbach
I'm looking for a Swiss department to host me for an SNSF Starting Grant.
I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com
If your department might be a match, let’s chat!
I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com
If your department might be a match, let’s chat!
Home | Timothy Fuqua
timothyfuqua.com
February 10, 2026 at 10:42 AM
I'm looking for a Swiss department to host me for an SNSF Starting Grant.
I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com
If your department might be a match, let’s chat!
I research how gene expression evolves and emerges by combining wet lab + computational work in a variety of model systems (E. coli, Drosophila, yeast). More: timothyfuqua.com
If your department might be a match, let’s chat!
Reposted by Leander Goldbach
Goed stuk over het wetenschappelijk publicatiesysteem.
Mijn voorstel is om het systeem op de schop te gooien: "niet eerst op journals wachten voordat zij de kwaliteit beoordelen, maar gelijk publiceren en vervolgens in alle openheid de peerreview doen"
#PublishReviewCurate
@cwtsnl.bsky.social
Mijn voorstel is om het systeem op de schop te gooien: "niet eerst op journals wachten voordat zij de kwaliteit beoordelen, maar gelijk publiceren en vervolgens in alle openheid de peerreview doen"
#PublishReviewCurate
@cwtsnl.bsky.social
Bij extreme winstmarges denk je waarschijnlijk niet aan wetenschappelijke uitgevers. Toch slaan wetenschappers alarm: de tarieven voor ‘open’ publicaties rijzen de pan uit en staan niet in verhouding tot de werkelijke kosten. Publiek onderzoeksgeld verdwijnt zo rechtstreeks naar aandeelhouders.
Uitgevers maken melkkoe van ‘gratis’ toegang tot wetenschap
Wetenschappelijke uitgevers hebben een nieuwe goudmijn gevonden: onderzoekers duizenden euro’s laten betalen om hun werk ‘open’ te publiceren. Wat begon als een ideaal om kennis voor iedereen toeganke...
www.ftm.nl
February 3, 2026 at 6:15 PM
Goed stuk over het wetenschappelijk publicatiesysteem.
Mijn voorstel is om het systeem op de schop te gooien: "niet eerst op journals wachten voordat zij de kwaliteit beoordelen, maar gelijk publiceren en vervolgens in alle openheid de peerreview doen"
#PublishReviewCurate
@cwtsnl.bsky.social
Mijn voorstel is om het systeem op de schop te gooien: "niet eerst op journals wachten voordat zij de kwaliteit beoordelen, maar gelijk publiceren en vervolgens in alle openheid de peerreview doen"
#PublishReviewCurate
@cwtsnl.bsky.social
Reposted by Leander Goldbach
Last chance to submit an abstract to our symposium on fitness landscapes and genotype-phenotype maps!
New year, new conferences! Consider submitting to the symposium on Fitness landscapes and Genotype-phenotype maps, linking computational and experimental approaches (organising with @n-martin.bsky.social; @dbajic.bsky.social invited spreaker) at SMBE (28/6-2/7)! Abstract deadline February 3rd!
SMBE2026 Symposium 20 | Mapping fitness landscapes with mechanistic models, machine learning and experiments
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
📨 Abstract submission
smbe2026.org/abstracts
📋 Programme details
smbe2026.org/programme
#SMBE2026
February 2, 2026 at 9:28 AM
Last chance to submit an abstract to our symposium on fitness landscapes and genotype-phenotype maps!
Reposted by Leander Goldbach
Canadian PM Carney’s speech at Davos reportedly received a standing ovation.
The speech marked the end of an era.
It will no doubt be looked to as part of the historical record of the end of the transatlantic rules-based international order.
You can read the speech in full here:
The speech marked the end of an era.
It will no doubt be looked to as part of the historical record of the end of the transatlantic rules-based international order.
You can read the speech in full here:
The Carney doctrine
Open comment thread on the PM's Davos speech
open.substack.com
January 20, 2026 at 8:00 PM
Canadian PM Carney’s speech at Davos reportedly received a standing ovation.
The speech marked the end of an era.
It will no doubt be looked to as part of the historical record of the end of the transatlantic rules-based international order.
You can read the speech in full here:
The speech marked the end of an era.
It will no doubt be looked to as part of the historical record of the end of the transatlantic rules-based international order.
You can read the speech in full here:
Reposted by Leander Goldbach
DFG erlaubt Einsatz von KI in der Begutachtung.
Wenn wir jetzt noch die AI dazu kriegen, die komplette Forschung zu machen, haben wir den Menschen komplett von der Last des Forschungsprozzeses befreit und er kann sich komplett auf wichtige Dinge wie Reisekostenerstattungsanträge konzentrieren.
Wenn wir jetzt noch die AI dazu kriegen, die komplette Forschung zu machen, haben wir den Menschen komplett von der Last des Forschungsprozzeses befreit und er kann sich komplett auf wichtige Dinge wie Reisekostenerstattungsanträge konzentrieren.
Künstliche Intelligenz in der Begutachtung
www.dfg.de
January 8, 2026 at 10:16 AM
DFG erlaubt Einsatz von KI in der Begutachtung.
Wenn wir jetzt noch die AI dazu kriegen, die komplette Forschung zu machen, haben wir den Menschen komplett von der Last des Forschungsprozzeses befreit und er kann sich komplett auf wichtige Dinge wie Reisekostenerstattungsanträge konzentrieren.
Wenn wir jetzt noch die AI dazu kriegen, die komplette Forschung zu machen, haben wir den Menschen komplett von der Last des Forschungsprozzeses befreit und er kann sich komplett auf wichtige Dinge wie Reisekostenerstattungsanträge konzentrieren.
Reposted by Leander Goldbach
📣CALL FOR APPLICATIONS!! 📣
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
December 16, 2025 at 12:51 PM
📣CALL FOR APPLICATIONS!! 📣
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
Good and necessarily infuriating read.
Many are painfully aware that the environment within which we function -- as scientists -- needs fixing. We've come up with a proposal for academic renewal. It's not perfect, but its a start. Input, comments, suggestions are welcome. Making a difference matters 👇
doi.org/10.5281/zeno...
doi.org/10.5281/zeno...
Pursuit of Knowledge: A Charter for Academic Renewal
This paper identifies systemic problems in how academic research is structured, evaluated, and supported. It argues for a realignment of incentives and institutional cultures to restore trust, enable ...
doi.org
December 1, 2025 at 3:52 PM
Good and necessarily infuriating read.
Reposted by Leander Goldbach
From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics' Web of Science, along with the Core Collection and Journal Citation Reports.
The CNRS is breaking free from the Web of Science
From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics'
www.cnrs.fr
December 1, 2025 at 11:04 AM
From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics' Web of Science, along with the Core Collection and Journal Citation Reports.
Reposted by Leander Goldbach
Doing non-causal inference (and being explicit about it), yet using a causal word as second word in the title.
If you pay Nature € 10.690, they will publish this in Nature Ageing.
I can tell you what I think of that for free.
www.nature.com/articles/s43...
If you pay Nature € 10.690, they will publish this in Nature Ageing.
I can tell you what I think of that for free.
www.nature.com/articles/s43...
November 11, 2025 at 7:58 AM
Doing non-causal inference (and being explicit about it), yet using a causal word as second word in the title.
If you pay Nature € 10.690, they will publish this in Nature Ageing.
I can tell you what I think of that for free.
www.nature.com/articles/s43...
If you pay Nature € 10.690, they will publish this in Nature Ageing.
I can tell you what I think of that for free.
www.nature.com/articles/s43...
Reposted by Leander Goldbach
📣CALL FOR APPLICATIONS!!
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
November 13, 2025 at 12:30 PM
📣CALL FOR APPLICATIONS!!
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
The next deadline for the #GodfreyHewitt mobility award is 31st January 2026. Open to ECRS in support of research trips or lab visits.
For more information, eligibility and how to apply: eseb.org/prizes-fundi...
Reposted by Leander Goldbach
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
October 20, 2025 at 6:14 PM
I’m excited to announce the launch of my lab at EPFL in Jan 2026 🎉. We’ll combine evolution & synthetic biology to study and (re)engineer bacterial communication.
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
I’m recruiting PhD students to start in the first semester of 2026.
Apply via EPFL PhD programs by Nov 1
drive.google.com/file/d/1cm-t...
Reposted by Leander Goldbach
Opportunity for a Master’s/Bachelor’s student:
- Join us for up to 5 months 🗓️
- Build computational/mathematical models 💻
- Learn about genotype-phenotype maps and evolution 🧬
- Work closely with PhD student Manuela Giraud - full info here:
www.crg.eu/en/content/t...
- Join us for up to 5 months 🗓️
- Build computational/mathematical models 💻
- Learn about genotype-phenotype maps and evolution 🧬
- Work closely with PhD student Manuela Giraud - full info here:
www.crg.eu/en/content/t...
October 7, 2025 at 2:38 PM
Opportunity for a Master’s/Bachelor’s student:
- Join us for up to 5 months 🗓️
- Build computational/mathematical models 💻
- Learn about genotype-phenotype maps and evolution 🧬
- Work closely with PhD student Manuela Giraud - full info here:
www.crg.eu/en/content/t...
- Join us for up to 5 months 🗓️
- Build computational/mathematical models 💻
- Learn about genotype-phenotype maps and evolution 🧬
- Work closely with PhD student Manuela Giraud - full info here:
www.crg.eu/en/content/t...
Reposted by Leander Goldbach
Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Uni Bern: Assistant Professor with tenure-track for Quantitative Cell Biology
Start date of employment: anticipated for August 2027
ohws.prospective.ch
October 7, 2025 at 11:17 AM
Please spread the word! 10 days left to apply for this #sciencejobs as Assistant Professor Tenure Track in Quantitative Cell Biology 👩🔬
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
@izb-unibern.bsky.social @unibe.ch! ohws.prospective.ch/public/v1/jo...
#QueerInSTEM #DisabledInSTEM #BlackInSTEM #WomenInSTEM #CarersInSTEM #AcademicSky #HigherED
Reposted by Leander Goldbach
I'm curious if other mid career PIs have considered completely abandoning the trad publication model. We've been making gradual moves towards that end goal. But it's been difficult to completely jump ship for one main reason for me at least. 1/
September 16, 2025 at 5:43 AM
I'm curious if other mid career PIs have considered completely abandoning the trad publication model. We've been making gradual moves towards that end goal. But it's been difficult to completely jump ship for one main reason for me at least. 1/
As a junior researcher who is at the doorstep of the journal publishing system this post resonates with me a lot. Journal publishing looks like a historical contingency that's kept alive by the career promises that Nature publications make.
thescientistpapers.substack.com/p/how-to-be-...
thescientistpapers.substack.com/p/how-to-be-...
How to be a scientist in a post-journal world
When we created this site to write about things in science that need to be fixed, we chose not to start with publishing, even though it has been our preoccupation for decades.
thescientistpapers.substack.com
September 9, 2025 at 8:25 AM
As a junior researcher who is at the doorstep of the journal publishing system this post resonates with me a lot. Journal publishing looks like a historical contingency that's kept alive by the career promises that Nature publications make.
thescientistpapers.substack.com/p/how-to-be-...
thescientistpapers.substack.com/p/how-to-be-...
Reposted by Leander Goldbach
Reposted by Leander Goldbach
#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Escherichia coli selection strains for growth-coupled metabolic engineering
Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an…
www.sciencedirect.com
July 12, 2025 at 3:57 PM
#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Leander Goldbach
Hey y'all, grant-pending, I may be unemployed starting from October. If you have any leads on biotech / postdoc positions in the German-speaking part of Switzerland, I'd greatly appreciate a message. I'm great with Data Analysis, Molecular Biology, and Teaching. (Plz RT!)
More at timothyfuqua.com
More at timothyfuqua.com
Home | Timothy Fuqua
timothyfuqua.com
June 24, 2025 at 12:07 PM
Hey y'all, grant-pending, I may be unemployed starting from October. If you have any leads on biotech / postdoc positions in the German-speaking part of Switzerland, I'd greatly appreciate a message. I'm great with Data Analysis, Molecular Biology, and Teaching. (Plz RT!)
More at timothyfuqua.com
More at timothyfuqua.com
Reposted by Leander Goldbach
"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
Rachel Thomas, PhD - Deep learning gets the glory, deep fact checking gets ignored
an AI researcher going back to school for immunology
rachel.fast.ai
June 4, 2025 at 3:53 PM
"a fascinating case study on the limits of AI in biology and the harms of current publishing incentives" rachel.fast.ai/posts/2025-0...
Reposted by Leander Goldbach
🔊 ¡Llamado a pensar la evolución desde el sur!
Invitamos a estudiantes de maestría y doctorado en biología evolutiva de Sudamérica a postularse a EvoSur.
🧬 Un espacio para intercambiar ideas, debatir evolución y tejer redes científicas con todas las voces, todas:
sites.google.com/view/evosur2...
Invitamos a estudiantes de maestría y doctorado en biología evolutiva de Sudamérica a postularse a EvoSur.
🧬 Un espacio para intercambiar ideas, debatir evolución y tejer redes científicas con todas las voces, todas:
sites.google.com/view/evosur2...
EvoSur
MOTIVACIÓN
https://sites.google.com/view/evosur2025/página-inicial
June 2, 2025 at 9:30 PM
🔊 ¡Llamado a pensar la evolución desde el sur!
Invitamos a estudiantes de maestría y doctorado en biología evolutiva de Sudamérica a postularse a EvoSur.
🧬 Un espacio para intercambiar ideas, debatir evolución y tejer redes científicas con todas las voces, todas:
sites.google.com/view/evosur2...
Invitamos a estudiantes de maestría y doctorado en biología evolutiva de Sudamérica a postularse a EvoSur.
🧬 Un espacio para intercambiar ideas, debatir evolución y tejer redes científicas con todas las voces, todas:
sites.google.com/view/evosur2...
Reposted by Leander Goldbach
How can physics contribute to understanding the evolution of complexity? Although great results have been produced over the last decades, some recent "theories" appear to ignore key ideas from evolutionary theory and are seriously flawed. Check this paper in PNAS www.pnas.org/doi/abs/10.1...
May 31, 2025 at 3:55 PM
How can physics contribute to understanding the evolution of complexity? Although great results have been produced over the last decades, some recent "theories" appear to ignore key ideas from evolutionary theory and are seriously flawed. Check this paper in PNAS www.pnas.org/doi/abs/10.1...
Reposted by Leander Goldbach
Here is a cool Flow-Lenia simulation, which is a continuous cellular automaton with two distinct features:
1. Mass conservation - sum of all activations is constant through time
2. Localized update rules - enables simulations with differently behaving matter on the same grid
1. Mass conservation - sum of all activations is constant through time
2. Localized update rules - enables simulations with differently behaving matter on the same grid
May 9, 2025 at 9:17 PM
Here is a cool Flow-Lenia simulation, which is a continuous cellular automaton with two distinct features:
1. Mass conservation - sum of all activations is constant through time
2. Localized update rules - enables simulations with differently behaving matter on the same grid
1. Mass conservation - sum of all activations is constant through time
2. Localized update rules - enables simulations with differently behaving matter on the same grid
Was protein size the constraint that made splicing and thus nuclei necessary for biological novelty 2.3-2.6My ago? Elegant paper with exciting implications.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
The emergence of eukaryotes as an evolutionary algorithmic phase transition | PNAS
The origin of eukaryotes represents one of the most significant events in evolution
since it allowed the posterior emergence of multicellular organ...
www.pnas.org
May 8, 2025 at 12:12 PM
Was protein size the constraint that made splicing and thus nuclei necessary for biological novelty 2.3-2.6My ago? Elegant paper with exciting implications.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Allobates zaparo knows it's a fraud.
We have a new paper on mimicry and behaviour in poison frogs out now in @jevbio.bsky.social 🧪🌎
The non-toxic mimic Allobates zaparo mimics the bold behaviour of the poisonous Ameerega bilinguis, but is more likely to jump before physical contact from a predator
academic.oup.com/jeb/advance-...
The non-toxic mimic Allobates zaparo mimics the bold behaviour of the poisonous Ameerega bilinguis, but is more likely to jump before physical contact from a predator
academic.oup.com/jeb/advance-...
April 9, 2025 at 11:59 AM
Allobates zaparo knows it's a fraud.
