Kate LeGrand
@lekate.bsky.social
PhD candidate with the LSHTM TB Modelling Group | Geospatial epi, med anthro, and community-based research
Pinned
Kate LeGrand
@lekate.bsky.social
· Nov 17
Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁
Come join the @lshtm-tbmod.bsky.social for a PhD!
Interested in #TB, equity, and modelling? @reinhouben.bsky.social and I are advertising an MRC LID studentship on heterogeneity in the coverage of community screening for TB @lshtm-tbmod.bsky.social @lshtm.bsky.social.
For more details, visit mrc-lid.lshtm.ac.uk/2026-27-proj...
For more details, visit mrc-lid.lshtm.ac.uk/2026-27-proj...
November 11, 2025 at 3:10 PM
Come join the @lshtm-tbmod.bsky.social for a PhD!
Reposted by Kate LeGrand
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants that drive tuberculosis,
the world's leading cause of death from a single infectious agent. However, tuberculosis
is often neglected in w...
www.thelancet.com
October 31, 2025 at 9:12 AM
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Kate LeGrand
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say…
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the
risk of people developing tuberculosis disease and of poor outcomes in those who do.1
Each year, WHO publishes estima...
www.thelancet.com
October 28, 2025 at 9:44 AM
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say…
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Reposted by Kate LeGrand
When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Impact of fluoroquinolone resistance on the cost-effectiveness of empiric treatment for multidrug- or rifampicin-resistant tuberculosis
The WHO recommends the bedaquiline, pretomanid, and linezolid (BPaL) regimen with the additional fluoroquinolone antibiotic moxifloxacin (BPaLM) for initial treatment of multidrug- or rifampicin-resis...
doi.org
October 20, 2025 at 6:47 PM
When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Reposted by Kate LeGrand
Nutritional status is a key determinant of TB. In this updated systematic review and dose-response meta-analysis (43 cohorts inc > 26 million people) we redefined the relationship between body mass index (BMI) and TB. doi.org/10.1093/ije/...
Body mass index and tuberculosis risk: an updated systematic literature review and dose–response meta-analysis
AbstractBackground. The relationship between nutritional status and tuberculosis is critically important but poorly understood. We extended a 2009 review c
doi.org
September 9, 2025 at 8:35 AM
Nutritional status is a key determinant of TB. In this updated systematic review and dose-response meta-analysis (43 cohorts inc > 26 million people) we redefined the relationship between body mass index (BMI) and TB. doi.org/10.1093/ije/...
Reposted by Kate LeGrand
At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise
Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...
bit.ly
September 5, 2025 at 10:05 AM
At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
📯 New research from @kchorton.bsky.social and colleagues from @lshtm-tbmod.bsky.social!
#TB incidence can rebound after community screening ends, meaning the gains made during a program can be erased in the years that follow. This highlights a major challenge in sustaining impact #EndTB #EpiSky
#TB incidence can rebound after community screening ends, meaning the gains made during a program can be erased in the years that follow. This highlights a major challenge in sustaining impact #EndTB #EpiSky
Community screening for #tuberculosis could extend the reach of #TB services, but evidence on its effectiveness is limited.
In our latest preprint, we examine the epidemiological impact of trade-offs in diagnostic algorithm, population coverage, and duration of screening. 1/n
bit.ly/3UK7pFD
In our latest preprint, we examine the epidemiological impact of trade-offs in diagnostic algorithm, population coverage, and duration of screening. 1/n
bit.ly/3UK7pFD
Exploring trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis
Background Current tuberculosis (TB) prevention and care strategies have failed to reduce disease burden at the pace required to meet global targets. Community screening may enable more rapid declines...
www.medrxiv.org
September 2, 2025 at 2:27 PM
📯 New research from @kchorton.bsky.social and colleagues from @lshtm-tbmod.bsky.social!
#TB incidence can rebound after community screening ends, meaning the gains made during a program can be erased in the years that follow. This highlights a major challenge in sustaining impact #EndTB #EpiSky
#TB incidence can rebound after community screening ends, meaning the gains made during a program can be erased in the years that follow. This highlights a major challenge in sustaining impact #EndTB #EpiSky
Reposted by Kate LeGrand
Reposted by Kate LeGrand
Our work estimating the potential impacts of reductions in international donor funding for #TB is now out in @lancetgh.bsky.social:
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
July 14, 2025 at 8:46 AM
Our work estimating the potential impacts of reductions in international donor funding for #TB is now out in @lancetgh.bsky.social:
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
bit.ly/3TDl28T
@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social
Our new study examines social contact patterns in urban, peri-urban, and rural communities and their implications for #TB interventions like household contact tracing, infection prevention, and cluster RCTs. #MedSky #EpiSky #IDsky #TBSky
Read more in @plosglobalpublichealth.org
Read more in @plosglobalpublichealth.org
Within-country heterogeneity in patterns of social contact relevant for tuberculosis infection transmission, prevention, and care
Mycobacterium tuberculosis (Mtb) transmission is driven by variable social, environmental, and biological factors, including the number and duration of indoor contacts. Social contact data can provide...
doi.org
July 15, 2025 at 9:49 PM
Reposted by Kate LeGrand
Great op-ed @usatoday.com from longtime TB Fighter Quinn Yates: www.usatoday.com/story/opinio...
11,000 more TB patients died after Trump's USAID cuts. That number will rise. | Opinion
The potential for thousands of new deaths from TB is not worth the less than 1% in federal savings that came from cutting USAID.
www.usatoday.com
July 8, 2025 at 1:19 PM
Great op-ed @usatoday.com from longtime TB Fighter Quinn Yates: www.usatoday.com/story/opinio...
Reposted by Kate LeGrand
New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
July 2, 2025 at 2:57 PM
New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Kate LeGrand
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
July 4, 2025 at 11:25 AM
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Reposted by Kate LeGrand
Tuberculosis still kills around 1.3 million people every year.
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
June 9, 2025 at 6:17 AM
Tuberculosis still kills around 1.3 million people every year.
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
It was once a massive killer in Europe and the US, but not anymore. How did these countries manage to tackle it?
Our first article on TB in a three-part series: ourworldindata.org/tuberculosis...
Reposted by Kate LeGrand
TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...
Tuberculosis and climate change: analytical framework and knowledge gaps
This report explores the intersection of tuberculosis (TB) and climate change, highlighting how climate-related challenges such as food and water insecurity, displacement, and disrupted healthcare acc...
www.who.int
May 30, 2025 at 8:30 AM
TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...
Reposted by Kate LeGrand
Can you believe it’s already been 25 years!?
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
25th anniversary celebrations of the Introduction to Infectious Disease
Our special event will celebrate the 25th anniversary of the Introduction to Infectious Disease Modelling and its Applications course, delivered by the London School of Hygiene & Tropical Medicine
www.lshtm.ac.uk
May 28, 2025 at 10:39 AM
Can you believe it’s already been 25 years!?
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
Reposted by Kate LeGrand
The chest x-ray use pioneered by Alan Hart continues to be extremely important in screening for tuberculosis. Although no one accomplishes anything in isolation, I'd argue that Hart has helped saved MILLIONS of lives because chest x-rays have been so essential in driving down rates of TB globally.
Remembering Dr. Alan Hart for Pride, trans man from the early 1900s. He revolutionized the detection of tuberculosis, saved thousands of lives, and died using his name, as the man he always was meant to be.
We have always been here.
We have always been here.
June 2, 2025 at 12:55 PM
The chest x-ray use pioneered by Alan Hart continues to be extremely important in screening for tuberculosis. Although no one accomplishes anything in isolation, I'd argue that Hart has helped saved MILLIONS of lives because chest x-rays have been so essential in driving down rates of TB globally.
Reposted by Kate LeGrand
Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.
May 27, 2025 at 2:50 PM
Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.
Come work with us at @lshtm-tbmod.bsky.social!
🏁Application closes Friday
🏁Application closes Friday
Are you interested in #TB and have experience in #modelling infectious diseases?
Come join us in the TB Modelling Group at #LSHTM!
We're advertising for a 1 year Research Fellow position, with a closing date of 30 May 2025 👉 jobs.lshtm.ac.uk/vacancy.aspx...
Come join us in the TB Modelling Group at #LSHTM!
We're advertising for a 1 year Research Fellow position, with a closing date of 30 May 2025 👉 jobs.lshtm.ac.uk/vacancy.aspx...
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is a world-leading centre for research and postgraduate education in public and global health. Our mission is to is to improve health and healt...
jobs.lshtm.ac.uk
May 27, 2025 at 2:19 PM
Come work with us at @lshtm-tbmod.bsky.social!
🏁Application closes Friday
🏁Application closes Friday
New preprint out from @raclark18.bsky.social, @kchorton.bsky.social, and colleagues from @lshtm-tbmod.bsky.social. The sudden withdrawal of international aid risks reversing years of hard-won gains. Beyond USAID, potential funding cuts via The Global Fund could add nearly 1M #TB deaths #EpiSky
#Tuberculosis prevention and care relies heavily on international donor funding in many settings. In our latest preprint, we examine the potential impact of reductions in international donor funding for #TB - by the US and by other major donor countries. 1/8
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
The potential impact of reductions in international donor funding on tuberculosis in low- and middle-income countries
Background Tuberculosis services in many settings rely heavily on international donor funding. In 2025, the United States Agency for International Development (USAID) was dismantled, and other countri...
www.medrxiv.org
April 29, 2025 at 2:17 PM
New preprint out from @raclark18.bsky.social, @kchorton.bsky.social, and colleagues from @lshtm-tbmod.bsky.social. The sudden withdrawal of international aid risks reversing years of hard-won gains. Beyond USAID, potential funding cuts via The Global Fund could add nearly 1M #TB deaths #EpiSky
Reposted by Kate LeGrand
Modelling projects the devastating impacts of US funding cuts, including our estimates of #TB incidence and deaths @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
A Lancet preprint estimates that if US funding is cut and not replaced, from 2025-2040 there will be 15.2 mil add'l AIDS deaths, 2.2 mil add'l TB deaths, 7.9 mil add'l child deaths from other causes, and 40-55 mil add'l unplanned pregnancies.
@altusaid.altgov.info
papers.ssrn.com/sol3/papers....
@altusaid.altgov.info
papers.ssrn.com/sol3/papers....
April 22, 2025 at 8:43 AM
Modelling projects the devastating impacts of US funding cuts, including our estimates of #TB incidence and deaths @lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Reposted by Kate LeGrand
New review article
Integrating genomic and spatial analyses to describe #tuberculosis transmission: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TB #OpenAccess #OA
Integrating genomic and spatial analyses to describe #tuberculosis transmission: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TB #OpenAccess #OA
April 11, 2025 at 8:26 AM
New review article
Integrating genomic and spatial analyses to describe #tuberculosis transmission: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TB #OpenAccess #OA
Integrating genomic and spatial analyses to describe #tuberculosis transmission: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #TB #OpenAccess #OA
Reposted by Kate LeGrand
Great to be able to finally get this work out, closing out my time with @lshtm-tbmod.bsky.social
New preprint led by @alexandra-richards.bsky.social & @kchorton.bsky.social from @lightontb.bsky.social
Eliminating men’s excess risks for #TB & improving access to treatment to comparable rates to women could have major gains for men, women & children.
www.medrxiv.org/content/10.1...
Eliminating men’s excess risks for #TB & improving access to treatment to comparable rates to women could have major gains for men, women & children.
www.medrxiv.org/content/10.1...
April 3, 2025 at 1:14 PM
Great to be able to finally get this work out, closing out my time with @lshtm-tbmod.bsky.social
Reposted by Kate LeGrand
In 2024, 68 million people were internally displaced by humanitarian crises, & are at increased risk of TB, the world's biggest infectious disease killer. We urgently need estimates to identify the scale of this problem & drive our response. We provide initial numbers here gh.bmj.com/content/10/3...
Thinking fast and slow: the urgency of crisis response must not lead us to overlook chronic needs such as tuberculosis
The number of people facing displacement due to humanitarian crises worldwide is increasing rapidly and is likely to continue. An average 10% year-on-year increase in the last 5 years resulted in 68.3...
gh.bmj.com
March 26, 2025 at 10:02 AM
In 2024, 68 million people were internally displaced by humanitarian crises, & are at increased risk of TB, the world's biggest infectious disease killer. We urgently need estimates to identify the scale of this problem & drive our response. We provide initial numbers here gh.bmj.com/content/10/3...
Reposted by Kate LeGrand
Undernutrition is the leading risk factor for TB globally, so its very exciting to see this roadmap for integrating nutrition into the care of people with TB out now in @lancetgh.bsky.social, led by the amazing @tbtakenseriously.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A roadmap for integrating nutritional assessment, counselling, and support into the care of people with tuberculosis
Undernutrition—the leading risk factor for tuberculosis worldwide—is associated with impaired immunity, more extensive disease, delayed sputum convers…
www.sciencedirect.com
March 20, 2025 at 9:35 AM
Undernutrition is the leading risk factor for TB globally, so its very exciting to see this roadmap for integrating nutrition into the care of people with TB out now in @lancetgh.bsky.social, led by the amazing @tbtakenseriously.bsky.social
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...