Marc-André Legault
@legaultm.bsky.social
Genetic epidemiology and pharmacogenomics research, U de Montréal
My main postdoc project is now published in @AJHG! We describe a MR estimator (Quantile IV) that does not rely on parametric assumptions and allows for heterogeneous causal effects. www.cell.com/ajhg/abstrac...
A flexible machine learning Mendelian randomization estimator applied to predict the safety and efficacy of sclerostin inhibition
Mendelian randomization (MR) enables the estimation of causal effects while controlling
for unmeasured confounding factors, but MR estimators often rely on strong parametric
assumptions. We propose an...
www.cell.com
May 15, 2025 at 3:13 PM
My main postdoc project is now published in @AJHG! We describe a MR estimator (Quantile IV) that does not rely on parametric assumptions and allows for heterogeneous causal effects. www.cell.com/ajhg/abstrac...
Reposted by Marc-André Legault
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
March 12, 2025 at 12:36 PM
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
Join us at UdeM and CHU Sainte-Justine! The bioinformatics community at Sainte-Justine is growing, and our clinician colleagues are really great.
Faculty position opening in bioinformatics at the University of Montreal! There is a great bioinfo and comp bio community in Montreal.
www.umontreal.ca/carrieres/pr...
www.umontreal.ca/carrieres/pr...
Professeurs
www.umontreal.ca
February 28, 2025 at 5:46 PM
Join us at UdeM and CHU Sainte-Justine! The bioinformatics community at Sainte-Justine is growing, and our clinician colleagues are really great.
Reposted by Marc-André Legault
Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics
This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.
nature.com
February 19, 2025 at 10:44 AM
Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️
Reposted by Marc-André Legault
Excited to share a new paper from @insitro.bsky.social (first author @zmccaw.bsky.social ) in @hggadvances.bsky.social vances.bsky.social on scrutinizing the practice of using a ratio trait (numerator / denominator) for GWAS.
www.cell.com/hgg-advances...
www.cell.com/hgg-advances...
Pitfalls in performing genome-wide association studies on ratio traits
Any variant associated with either numerator or denominator will associate with the
ratio in GWAS of sufficient size. Associations with ratio traits are thus not specific
to the ratio. Instead, we rec...
www.cell.com
February 11, 2025 at 12:38 PM
Excited to share a new paper from @insitro.bsky.social (first author @zmccaw.bsky.social ) in @hggadvances.bsky.social vances.bsky.social on scrutinizing the practice of using a ratio trait (numerator / denominator) for GWAS.
www.cell.com/hgg-advances...
www.cell.com/hgg-advances...
Reposted by Marc-André Legault
I used to put our open-source software on business card-sized CD ROMs & pass them out at conferences. We had code, sample data, & PDFs on the disk.
December 17, 2024 at 10:58 PM
I used to put our open-source software on business card-sized CD ROMs & pass them out at conferences. We had code, sample data, & PDFs on the disk.
Reposted by Marc-André Legault
Dear early career genetic epidemiologists:
The IGES Young Investigator Committee is looking for new members! It's a fun group, low time commitment, and great way to network with peers while supporting trainees around the world.
Apply here by Dec 31st:
www.geneticepi.org/yic_position...
The IGES Young Investigator Committee is looking for new members! It's a fun group, low time commitment, and great way to network with peers while supporting trainees around the world.
Apply here by Dec 31st:
www.geneticepi.org/yic_position...
December 13, 2024 at 7:42 PM
Dear early career genetic epidemiologists:
The IGES Young Investigator Committee is looking for new members! It's a fun group, low time commitment, and great way to network with peers while supporting trainees around the world.
Apply here by Dec 31st:
www.geneticepi.org/yic_position...
The IGES Young Investigator Committee is looking for new members! It's a fun group, low time commitment, and great way to network with peers while supporting trainees around the world.
Apply here by Dec 31st:
www.geneticepi.org/yic_position...
Reposted by Marc-André Legault
🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
November 18, 2024 at 8:19 PM
🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...
Interested in Mendelian randomization and proteomics? 🧬
We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!
Preprint: www.medrxiv.org/content/10.1...
Website: broad.io/protein_mr_a...