@lauriemengerlab.bsky.social
Reposted
@biorxivpreprint.bsky.social In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumor @ucsfhealth.bsky.social @gladstoneinst.bsky.social www.biorxiv.org/content/10.1...
September 25, 2025 at 3:17 AM
@biorxivpreprint.bsky.social In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumor @ucsfhealth.bsky.social @gladstoneinst.bsky.social www.biorxiv.org/content/10.1...
Reposted
🚨 available postdoc position 🚨 in the laboratory of @guermonprezlab.bsky.social at the Pasteur institute in Paris, France, to work on DC function within tumors. Exciting project, amazing institute and so on...
March 12, 2025 at 1:19 PM
🚨 available postdoc position 🚨 in the laboratory of @guermonprezlab.bsky.social at the Pasteur institute in Paris, France, to work on DC function within tumors. Exciting project, amazing institute and so on...
Reposted
Huge study in @nature.com by the @roychoudhurilab.bsky.social group
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
www.nature.com
March 7, 2025 at 3:09 PM
Huge study in @nature.com by the @roychoudhurilab.bsky.social group
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
#Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. This could potentially revolutionize cancer treatment and make it so much more accessible!
Reposted
Excited to share our latest work, now out in
@NatureBiotech
! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇
www.nature.com/articles/s41...
@NatureBiotech
! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇
www.nature.com/articles/s41...
SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci - Nature Biotechnology
Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.
www.nature.com
February 5, 2025 at 7:03 PM
Excited to share our latest work, now out in
@NatureBiotech
! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇
www.nature.com/articles/s41...
@NatureBiotech
! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇
www.nature.com/articles/s41...
🚨New paper alert! 🚨 Our latest work in
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
@cp-immunity.bsky.social shows that Ark313, an evolved AAV variant enables in vivo genetic engineering of murine T cells! 🧵👇
sciencedirect.com/science/arti...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Genetic engineering of T cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach to manipulate T cells…
sciencedirect.com
February 5, 2025 at 4:33 PM
Reposted
I'm delighted to share a new story from our lab published today at @cp-cellmetabolism.bsky.social! In it, we describe how cellular therapies for cancer can be metabolically and epigenetically enhanced by redirecting how glucose is utilized during in vitro expansion. 1/ www.cell.com/cell-metabol...
Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy
T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic
conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive
aerobic glycolysis. Rer...
www.cell.com
January 28, 2025 at 6:34 PM
I'm delighted to share a new story from our lab published today at @cp-cellmetabolism.bsky.social! In it, we describe how cellular therapies for cancer can be metabolically and epigenetically enhanced by redirecting how glucose is utilized during in vitro expansion. 1/ www.cell.com/cell-metabol...