@laurenlporter.bsky.social
Investigates shapeshifting proteins with computation and experiment. Tenure-track. Mother of two. Foodie. Yoga lover. Opinions are mine.
Reposted
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
March 26, 2025 at 4:21 PM
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
Reposted
🚨 New preprint alert! 🚨 How does SARS-CoV-2 use as much of its genome as possible to evade our immune response? Our latest study dissects how Orf9b, which is encoded in an alternate reading frame from the N(ucleocapsid) protein, can regulate interferon signaling.
www.biorxiv.org/content/10.1...
🧵👇
www.biorxiv.org/content/10.1...
🧵👇
Coupled equilibria of dimerization and lipid binding modulate SARS Cov 2 Orf9b interactions and interferon response
Open Reading Frame 9b (Orf9b), an accessory protein of SARS-CoV and -2, is involved in innate immune suppression through its binding to the mitochondrial receptor Translocase of Outer Membrane 70 (Tom...
www.biorxiv.org
February 18, 2025 at 10:22 PM
🚨 New preprint alert! 🚨 How does SARS-CoV-2 use as much of its genome as possible to evade our immune response? Our latest study dissects how Orf9b, which is encoded in an alternate reading frame from the N(ucleocapsid) protein, can regulate interferon signaling.
www.biorxiv.org/content/10.1...
🧵👇
www.biorxiv.org/content/10.1...
🧵👇
Our latest review is out in Current Opinion: Proteins with alternative folds reveal blind spots in AlphaFold-based protein structure prediction
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
January 6, 2025 at 5:34 PM
Our latest review is out in Current Opinion: Proteins with alternative folds reveal blind spots in AlphaFold-based protein structure prediction
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Our latest @bioRxiv manuscript reports an assessment of >500,000 AF2-based predictions of fold-switching proteins, which assume two distinct stable structures. These predictions fail to reflect observed energetics of fold switching 🧵 www.biorxiv.org/content/10.1...
AlphaFold2 has more to learn about protein energy landscapes
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
December 14, 2023 at 11:49 AM
Our latest @bioRxiv manuscript reports an assessment of >500,000 AF2-based predictions of fold-switching proteins, which assume two distinct stable structures. These predictions fail to reflect observed energetics of fold switching 🧵 www.biorxiv.org/content/10.1...