Lasse Middendorf
@lassemiddendorf.bsky.social
PhD Student at @CRG.eu | Synthetic Biology, Proteins & Evolution 🧬 | AI4ProteinDesign Lab
Reposted by Lasse Middendorf
Welcoming @lassemiddendorf.bsky.social as Mayor of iGEM’s Biomanufacturing Village.
This Village explores how we can grow the medicines, materials and commodities of the future using synthetic biology- powered by shared tools, scalable ideas and practical roadmaps.
villages.igem.org
This Village explores how we can grow the medicines, materials and commodities of the future using synthetic biology- powered by shared tools, scalable ideas and practical roadmaps.
villages.igem.org
May 16, 2025 at 9:52 AM
Welcoming @lassemiddendorf.bsky.social as Mayor of iGEM’s Biomanufacturing Village.
This Village explores how we can grow the medicines, materials and commodities of the future using synthetic biology- powered by shared tools, scalable ideas and practical roadmaps.
villages.igem.org
This Village explores how we can grow the medicines, materials and commodities of the future using synthetic biology- powered by shared tools, scalable ideas and practical roadmaps.
villages.igem.org
Reposted by Lasse Middendorf
It's long seemed that molecular biology is a natural home for ML interpretability research, given the maturity of human-constructed models of biological mechanisms—permitting direct comparison with their ML-derived counterparts—unlike vision and NLP. Our first foray below👇.
Can we learn protein biology from a language model?
In new work led by @liambai.bsky.social and me, we explore how sparse autoencoders can help us understand biology—going from mechanistic interpretability to mechanistic biology.
In new work led by @liambai.bsky.social and me, we explore how sparse autoencoders can help us understand biology—going from mechanistic interpretability to mechanistic biology.
February 10, 2025 at 4:15 PM
It's long seemed that molecular biology is a natural home for ML interpretability research, given the maturity of human-constructed models of biological mechanisms—permitting direct comparison with their ML-derived counterparts—unlike vision and NLP. Our first foray below👇.
Reposted by Lasse Middendorf
Join the ProSE Seminar Series! A monthly discussion on the #Evolution of #ProteinStructure 🧪
Next up: Andrei Lupas
“Highly repetitive genomic ORFs: a source of new fibrous proteins?”
11th February | 3 PM GMT
🔗 Register here: tinyurl.com/prose-seminar1
Next up: Andrei Lupas
“Highly repetitive genomic ORFs: a source of new fibrous proteins?”
11th February | 3 PM GMT
🔗 Register here: tinyurl.com/prose-seminar1
January 29, 2025 at 9:44 AM
Join the ProSE Seminar Series! A monthly discussion on the #Evolution of #ProteinStructure 🧪
Next up: Andrei Lupas
“Highly repetitive genomic ORFs: a source of new fibrous proteins?”
11th February | 3 PM GMT
🔗 Register here: tinyurl.com/prose-seminar1
Next up: Andrei Lupas
“Highly repetitive genomic ORFs: a source of new fibrous proteins?”
11th February | 3 PM GMT
🔗 Register here: tinyurl.com/prose-seminar1
Reposted by Lasse Middendorf
This is an important problem. 👏
Detecting and avoiding homology-based data leakage in genome-trained sequence models https://www.biorxiv.org/content/10.1101/2025.01.22.634321v1
January 25, 2025 at 3:58 AM
This is an important problem. 👏
Highlighting the amazing research at the #CRGPhDSymp2024 Poster Session! Check out some snapshots from today’s sessions
November 29, 2024 at 2:43 PM
Highlighting the amazing research at the #CRGPhDSymp2024 Poster Session! Check out some snapshots from today’s sessions
Reposted by Lasse Middendorf
Super interesting talk from Gül Aydin’s about understanding the role of dynamic DNA methylation at
promoters during B-cell differentiation at the #CRGPhDSymp2024
promoters during B-cell differentiation at the #CRGPhDSymp2024
November 29, 2024 at 11:38 AM
Super interesting talk from Gül Aydin’s about understanding the role of dynamic DNA methylation at
promoters during B-cell differentiation at the #CRGPhDSymp2024
promoters during B-cell differentiation at the #CRGPhDSymp2024
Reposted by Lasse Middendorf
Kicking us off today is Tamara Perteghella from the Guigó lab with her talk on the latest release of #GENCODE, dramatically increasing the number of annotated lncRNAs. Well done to everyone involved in the consortium! #CRGPhDSymp2024
November 29, 2024 at 11:19 AM
Kicking us off today is Tamara Perteghella from the Guigó lab with her talk on the latest release of #GENCODE, dramatically increasing the number of annotated lncRNAs. Well done to everyone involved in the consortium! #CRGPhDSymp2024
Reposted by Lasse Middendorf
November 29, 2024 at 11:06 AM
People are slowly getting settled for the second day of the #CRGPhDSymp2024
November 29, 2024 at 10:58 AM
People are slowly getting settled for the second day of the #CRGPhDSymp2024
Reposted by Lasse Middendorf
Learning about cell type diversity and evolution beyond gene expression thanks to the amazing talk from Paulina Spurk at the PhD Symposium.
#CRGPhDSymp2024
#CRGPhDSymp2024
November 28, 2024 at 12:14 PM
Learning about cell type diversity and evolution beyond gene expression thanks to the amazing talk from Paulina Spurk at the PhD Symposium.
#CRGPhDSymp2024
#CRGPhDSymp2024
Reposted by Lasse Middendorf
Great talk from Laia Montes Espuna at the @crg.eu PhD Symposium! Her work is focused on cell type diversity in early metazoans, aiming at broadening the understanding of cell type identity programs across the animal kingdom 🪸🧬 #CRGPhDSymp2024
November 28, 2024 at 11:18 AM
Great talk from Laia Montes Espuna at the @crg.eu PhD Symposium! Her work is focused on cell type diversity in early metazoans, aiming at broadening the understanding of cell type identity programs across the animal kingdom 🪸🧬 #CRGPhDSymp2024
Reposted by Lasse Middendorf
Navigating the #CRGPhDSymp2024 poster session, I’m slowly becoming an expert at nodding thoughtfully while frantically trying to understand someone’s life work in 3 minutes!
November 28, 2024 at 1:13 PM
Navigating the #CRGPhDSymp2024 poster session, I’m slowly becoming an expert at nodding thoughtfully while frantically trying to understand someone’s life work in 3 minutes!
Reposted by Lasse Middendorf
Great talk from Javier Navarro Delgado on understanding, predicting and engineering variant effects in synthetic antibodies. #AntibodyDiscover #CRGPhDSymp2024
November 28, 2024 at 10:22 AM
Great talk from Javier Navarro Delgado on understanding, predicting and engineering variant effects in synthetic antibodies. #AntibodyDiscover #CRGPhDSymp2024
Reposted by Lasse Middendorf
Very interesting talk from Pablo Lanuza about mechanistic understanding of splicing, titled SPF45 and 3'splice site proofreading.
#CRGPhDSymp2024 #splicing
#CRGPhDSymp2024 #splicing
November 28, 2024 at 11:30 AM
Very interesting talk from Pablo Lanuza about mechanistic understanding of splicing, titled SPF45 and 3'splice site proofreading.
#CRGPhDSymp2024 #splicing
#CRGPhDSymp2024 #splicing
Reposted by Lasse Middendorf
Thanks Charlie for opening the PhD Symposium! Many thanks to everyone involved in its organisation. #CRGPhDSymp2024
November 28, 2024 at 9:10 AM
Thanks Charlie for opening the PhD Symposium! Many thanks to everyone involved in its organisation. #CRGPhDSymp2024
Next up we have @javibiotec.bsky.social talking on using large-scale mutational experiments to understand the genetic architecture of nanobody stability
#CRGPhDSymp2024
#CRGPhDSymp2024
November 28, 2024 at 2:40 PM
Next up we have @javibiotec.bsky.social talking on using large-scale mutational experiments to understand the genetic architecture of nanobody stability
#CRGPhDSymp2024
#CRGPhDSymp2024
Reporting from the #CRGPhDSymp2024 today and tomorrow! Kicking it off with a fascinating talk Gioia Quarantani on DMS of a 1000 exons to investigate alternative splicing
November 28, 2024 at 12:11 PM
Reporting from the #CRGPhDSymp2024 today and tomorrow! Kicking it off with a fascinating talk Gioia Quarantani on DMS of a 1000 exons to investigate alternative splicing
Reposted by Lasse Middendorf
Our amazing CRG PhD community are celebrating their annual symposium
today and tomorrow.
Follow our first year students on Bluesky for snippets about all the amazing talks featured this year:
@lassemiddendorf.bsky.social
@mattezambon.bsky.social
@iseultleahy.bsky.social
today and tomorrow.
Follow our first year students on Bluesky for snippets about all the amazing talks featured this year:
@lassemiddendorf.bsky.social
@mattezambon.bsky.social
@iseultleahy.bsky.social
November 28, 2024 at 10:46 AM
Our amazing CRG PhD community are celebrating their annual symposium
today and tomorrow.
Follow our first year students on Bluesky for snippets about all the amazing talks featured this year:
@lassemiddendorf.bsky.social
@mattezambon.bsky.social
@iseultleahy.bsky.social
today and tomorrow.
Follow our first year students on Bluesky for snippets about all the amazing talks featured this year:
@lassemiddendorf.bsky.social
@mattezambon.bsky.social
@iseultleahy.bsky.social
Reposted by Lasse Middendorf
Ah, we have several positions open!
November 27, 2024 at 12:10 PM
Ah, we have several positions open!