Lara Goscé
@laragosce.bsky.social
Assistant Professor in Modelling at LSHTM, TB modeller
Reposted by Lara Goscé
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants that drive tuberculosis,
the world's leading cause of death from a single infectious agent. However, tuberculosis
is often neglected in w...
www.thelancet.com
October 31, 2025 at 9:12 AM
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Lara Goscé
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say…
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative
Undernutrition is a key driver of the global tuberculosis epidemic, increasing the
risk of people developing tuberculosis disease and of poor outcomes in those who do.1
Each year, WHO publishes estima...
www.thelancet.com
October 28, 2025 at 9:44 AM
“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say…
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...
Reposted by Lara Goscé
When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Impact of fluoroquinolone resistance on the cost-effectiveness of empiric treatment for multidrug- or rifampicin-resistant tuberculosis
The WHO recommends the bedaquiline, pretomanid, and linezolid (BPaL) regimen with the additional fluoroquinolone antibiotic moxifloxacin (BPaLM) for initial treatment of multidrug- or rifampicin-resis...
doi.org
October 20, 2025 at 6:47 PM
When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Reposted by Lara Goscé
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.
bit.ly/4nbV492
bit.ly/4nbV492
A global analysis of patterns of tuberculosis exposure and transmission
Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...
www.medrxiv.org
October 12, 2025 at 12:51 PM
Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries.
bit.ly/4nbV492
bit.ly/4nbV492
Reposted by Lara Goscé
In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening
Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...
www.medrxiv.org
October 7, 2025 at 9:17 AM
In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...
Reposted by Lara Goscé
At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise
Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...
bit.ly
September 5, 2025 at 10:05 AM
At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n
bit.ly/3V3vXth
Reposted by Lara Goscé
The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.
U.S. issues sanctions against United Nations investigator probing abuses in Gaza
The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.
n.pr
July 10, 2025 at 12:03 PM
The State Department's decision to impose sanctions on Francesca Albanese, the U.N. special rapporteur for the West Bank and Gaza, follows an unsuccessful campaign to force her removal.
Reposted by Lara Goscé
Secretary of State Marco Rubio has imposed sanctions on Francesca Albanese, the U.N. special rapporteur on the occupied Palestinian territory.
Albanese says the move is an effort to “distract” from the genocide in Gaza.
Albanese says the move is an effort to “distract” from the genocide in Gaza.
July 10, 2025 at 2:13 PM
Secretary of State Marco Rubio has imposed sanctions on Francesca Albanese, the U.N. special rapporteur on the occupied Palestinian territory.
Albanese says the move is an effort to “distract” from the genocide in Gaza.
Albanese says the move is an effort to “distract” from the genocide in Gaza.
Reposted by Lara Goscé
New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
July 2, 2025 at 2:57 PM
New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood.
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by Lara Goscé
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
July 4, 2025 at 11:25 AM
In our latest personal view in @lancetrespirmed.bsky.social, we argue for the inclusion asymptomatic #tuberculosis in vaccine trial endpoints to potentially reduce the size, length, and cost of trials.
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
doi.org/10.1016/S221...
@lshtm-tbmod.bsky.social @tb-lshtm.bsky.social
Reposted by Lara Goscé
A study in the Lancet recently looked at the cumulative impact of reductions in American aid. It found that, by 2040, 8 million more children will die before their fifth birthday. b-gat.es/44wCCQO
The Effects of Reductions in United States Foreign Assistance on Global Health
Background: The United States (US) has traditionally been the largest donor to health programs in low- and middle-income countries. In January 2025 almost all s
b-gat.es
July 3, 2025 at 11:22 PM
A study in the Lancet recently looked at the cumulative impact of reductions in American aid. It found that, by 2040, 8 million more children will die before their fifth birthday. b-gat.es/44wCCQO
Reposted by Lara Goscé
The facts are simple and devastating: Aid cuts have already cost lives, and the number of deaths will continue to rise. Here’s the evidence.
July 3, 2025 at 11:21 PM
The facts are simple and devastating: Aid cuts have already cost lives, and the number of deaths will continue to rise. Here’s the evidence.
Reposted by Lara Goscé
LSHTM's Director writes to UK Government about #Gaza public health catastrophe
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
June 20, 2025 at 1:32 PM
LSHTM's Director writes to UK Government about #Gaza public health catastrophe
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
Professor Liam Smeeth's letter to the Prime Minister & Foreign Secretary urges action to prevent a greater #PublicHealth disaster:
👉 www.lshtm.ac.uk/newsevents/n...
Reposted by Lara Goscé
Can you believe it’s already been 25 years!?
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
25th anniversary celebrations of the Introduction to Infectious Disease
Our special event will celebrate the 25th anniversary of the Introduction to Infectious Disease Modelling and its Applications course, delivered by the London School of Hygiene & Tropical Medicine
www.lshtm.ac.uk
May 28, 2025 at 10:39 AM
Can you believe it’s already been 25 years!?
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social!
More info 👉 www.lshtm.ac.uk/newsevents/e...
Reposted by Lara Goscé
TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...
Tuberculosis and climate change: analytical framework and knowledge gaps
This report explores the intersection of tuberculosis (TB) and climate change, highlighting how climate-related challenges such as food and water insecurity, displacement, and disrupted healthcare acc...
www.who.int
May 30, 2025 at 8:30 AM
TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...
Reposted by Lara Goscé
Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.
May 27, 2025 at 2:50 PM
Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.
Reposted by Lara Goscé
Postdoc (London, UK)
Position available in the world-leading tuberculosis (TB) Modelling group at LSHTM
with @raclark18.bsky.social @richardwhite321.bsky.social
at LSHTM @lshtm-tbmod.bsky.social
More details: http://iddjobs.org/jobs/2314
Position available in the world-leading tuberculosis (TB) Modelling group at LSHTM
with @raclark18.bsky.social @richardwhite321.bsky.social
at LSHTM @lshtm-tbmod.bsky.social
More details: http://iddjobs.org/jobs/2314
May 20, 2025 at 7:07 PM
Postdoc (London, UK)
Position available in the world-leading tuberculosis (TB) Modelling group at LSHTM
with @raclark18.bsky.social @richardwhite321.bsky.social
at LSHTM @lshtm-tbmod.bsky.social
More details: http://iddjobs.org/jobs/2314
Position available in the world-leading tuberculosis (TB) Modelling group at LSHTM
with @raclark18.bsky.social @richardwhite321.bsky.social
at LSHTM @lshtm-tbmod.bsky.social
More details: http://iddjobs.org/jobs/2314
Climate-driven migration and displacement and their potential impact on TB in Latin America gh.bmj.com/content/10/4... @cfmcquaid.bsky.social @reinhouben.bsky.social @lshtm-tbmod.bsky.social
Tuberculosis and the climate crisis in Latin America: a predicament of poverty, migration and displacement
Tuberculosis (TB) has long been associated with poverty and displacement, through food insecurity, overcrowding, poor living conditions and reduced access to healthcare, which significantly increase t...
gh.bmj.com
April 10, 2025 at 1:59 PM
Climate-driven migration and displacement and their potential impact on TB in Latin America gh.bmj.com/content/10/4... @cfmcquaid.bsky.social @reinhouben.bsky.social @lshtm-tbmod.bsky.social
Reposted by Lara Goscé
Climate change is likely to exacerbate determinants which drive TB, the world’s leading infectious disease killer. Commissioned by WHO, we developed an analytical framework outlining potential causal relationships between climate change and TB:
medrxiv.org/cgi/content/...
@lshtm.bsky.social @who.int
medrxiv.org/cgi/content/...
@lshtm.bsky.social @who.int
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world's leading infectious disease killer. However, tuberculosis is often neglected in wider climate health...
medrxiv.org
February 21, 2025 at 9:30 AM
Climate change is likely to exacerbate determinants which drive TB, the world’s leading infectious disease killer. Commissioned by WHO, we developed an analytical framework outlining potential causal relationships between climate change and TB:
medrxiv.org/cgi/content/...
@lshtm.bsky.social @who.int
medrxiv.org/cgi/content/...
@lshtm.bsky.social @who.int
Three PhD opportunities in modelling at @lshtm.bsky.social and @ukhsa.bsky.social on:
Homelessness/Housing and TB: shorturl.at/FJ57W
EBV and cancers in the UK: shorturl.at/IRHJk
Climate change and TB: shorturl.at/R7f50
Homelessness/Housing and TB: shorturl.at/FJ57W
EBV and cancers in the UK: shorturl.at/IRHJk
Climate change and TB: shorturl.at/R7f50
Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine on FindAPhD.com
PhD Project - Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine, listed on FindAPhD.com
shorturl.at
February 20, 2025 at 3:55 PM
Three PhD opportunities in modelling at @lshtm.bsky.social and @ukhsa.bsky.social on:
Homelessness/Housing and TB: shorturl.at/FJ57W
EBV and cancers in the UK: shorturl.at/IRHJk
Climate change and TB: shorturl.at/R7f50
Homelessness/Housing and TB: shorturl.at/FJ57W
EBV and cancers in the UK: shorturl.at/IRHJk
Climate change and TB: shorturl.at/R7f50
Reposted by Lara Goscé
PhD position (London, UK)
Quantify the effects of climate change on TB
with @cfmcquaid.bsky.social @reinhouben.bsky.social @laragosce.bsky.social
at @cmmid-lshtm.bsky.social @tb-lshtm.bsky.social @lshtm.bsky.social
More details: http://iddjobs.org/jobs/2253
Quantify the effects of climate change on TB
with @cfmcquaid.bsky.social @reinhouben.bsky.social @laragosce.bsky.social
at @cmmid-lshtm.bsky.social @tb-lshtm.bsky.social @lshtm.bsky.social
More details: http://iddjobs.org/jobs/2253
February 7, 2025 at 7:23 PM
PhD position (London, UK)
Quantify the effects of climate change on TB
with @cfmcquaid.bsky.social @reinhouben.bsky.social @laragosce.bsky.social
at @cmmid-lshtm.bsky.social @tb-lshtm.bsky.social @lshtm.bsky.social
More details: http://iddjobs.org/jobs/2253
Quantify the effects of climate change on TB
with @cfmcquaid.bsky.social @reinhouben.bsky.social @laragosce.bsky.social
at @cmmid-lshtm.bsky.social @tb-lshtm.bsky.social @lshtm.bsky.social
More details: http://iddjobs.org/jobs/2253
New PhD opportunity at LSHTM @lshtm.bsky.social @cmmid-lshtm.bsky.social and UKHSA
www.lshtm.ac.uk/study/fees-a...
www.lshtm.ac.uk/study/fees-a...
2025-26 UKHSA-LSHTM PhD Scholarship | LSHTM
The London School of Hygiene and Tropical Medicine (LSHTM) is pleased to invite applications for a 3-year full-time PhD studentship, starting in September 2025, held between the Faculty of
www.lshtm.ac.uk
February 4, 2025 at 5:41 PM
New PhD opportunity at LSHTM @lshtm.bsky.social @cmmid-lshtm.bsky.social and UKHSA
www.lshtm.ac.uk/study/fees-a...
www.lshtm.ac.uk/study/fees-a...
Reposted by Lara Goscé
1/ 📢 In our new PREPRINT - tinyurl.com/2pmudzrk - we evaluate how symptom-agnostic, population-wide screening interventions could significantly reduce the TB burden in Viet Nam. These require a substantial front-loaded investment but yield lasting cost savings. 🧵 #Tuberculosis #TBSky
Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam: a mathematical modelling study
Background Population-wide screening may accelerate the decline of tuberculosis (TB) incidence, but the optimal screening algorithm and duration must weigh resource considerations.
Methods We calibra...
tinyurl.com
January 6, 2025 at 5:27 PM
1/ 📢 In our new PREPRINT - tinyurl.com/2pmudzrk - we evaluate how symptom-agnostic, population-wide screening interventions could significantly reduce the TB burden in Viet Nam. These require a substantial front-loaded investment but yield lasting cost savings. 🧵 #Tuberculosis #TBSky
Our ASCENT modelling paper on Digital Adherence Technologies (DAT) for TB treatment is now out in BMJ Global Health gh.bmj.com/content/9/12... DATs may have limited epidemiological impact but can reduce costs and have important budgetary implications. @cfmcquaid.bsky.social @lshtm-tbmod.bsky.social
Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia
Background Digital adherence technologies (DATs) with associated differentiated care are potential tools to improve tuberculosis (TB) treatment outcomes and reduce associated costs for both patients a...
gh.bmj.com
December 10, 2024 at 12:42 PM
Our ASCENT modelling paper on Digital Adherence Technologies (DAT) for TB treatment is now out in BMJ Global Health gh.bmj.com/content/9/12... DATs may have limited epidemiological impact but can reduce costs and have important budgetary implications. @cfmcquaid.bsky.social @lshtm-tbmod.bsky.social
Reposted by Lara Goscé
Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁
November 17, 2024 at 7:56 PM
Reflecting on this year’s #TB #UnionConf2024 and am so inspired by the brilliant minds and groundbreaking research being done to combat this global health threat. Special shoutout to the TB Modelling Group @lshtm.bsky.social 🫁