Kristiaan Wouters
@kwouters.bsky.social
Associate Professor Translational Immunometabolism Maastricht University. Immunologist investigating cardiometabolic diseases.
Likes science, music and sports. Loves his wife and kids.
Likes science, music and sports. Loves his wife and kids.
New preprint! Liver macrophages are highly autofluorescent cells, complicating analysis. @sabinedaemen.bsky.social developed a spectral flow approach to resolve #macrophage subsets in healthy vs #MASLD livers.
#FlowCytometry #SpectralFlow #Autofluorescence
doi.org/10.64898/202...
#FlowCytometry #SpectralFlow #Autofluorescence
doi.org/10.64898/202...
doi.org
February 1, 2026 at 7:51 AM
New preprint! Liver macrophages are highly autofluorescent cells, complicating analysis. @sabinedaemen.bsky.social developed a spectral flow approach to resolve #macrophage subsets in healthy vs #MASLD livers.
#FlowCytometry #SpectralFlow #Autofluorescence
doi.org/10.64898/202...
#FlowCytometry #SpectralFlow #Autofluorescence
doi.org/10.64898/202...
Happy to share our latest publication showing that higher neutrophils and monocytes, but not other leukocytes, were linked to lower heart rate variability — a sign of reduced flexibility in how the heart responds to daily demands.
www.ahajournals.org/doi/10.1161/...
#inflammation #cardiovasular
www.ahajournals.org/doi/10.1161/...
#inflammation #cardiovasular
Circulating Neutrophil and Monocyte Counts Are Inversely Associated With Heart Rate Variability Indices: The Maastricht Study | Journal of the American Heart Association
www.ahajournals.org
January 24, 2026 at 6:08 AM
Happy to share our latest publication showing that higher neutrophils and monocytes, but not other leukocytes, were linked to lower heart rate variability — a sign of reduced flexibility in how the heart responds to daily demands.
www.ahajournals.org/doi/10.1161/...
#inflammation #cardiovasular
www.ahajournals.org/doi/10.1161/...
#inflammation #cardiovasular
📄 New paper published in Frontiers in Physiology!
We show that pyridoxamine reduces inflammation and microcirculatory dysfunction in MASH, modulating key hepatic AGE/ALE signaling pathways.
🔗 doi.org/10.3389/fphy...
#MASH #LiverDisease #Inflammation
We show that pyridoxamine reduces inflammation and microcirculatory dysfunction in MASH, modulating key hepatic AGE/ALE signaling pathways.
🔗 doi.org/10.3389/fphy...
#MASH #LiverDisease #Inflammation
Frontiers | Pyridoxamine reduces inflammatory and microcirculatory abnormalities in metabolic dysfunction-associated steatohepatitis and modulates key factors in the hepatic AGE/ALE signaling pathway
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasing public health concern for which new therapies are urgently needed. As growing eviden...
doi.org
January 19, 2026 at 12:07 PM
📄 New paper published in Frontiers in Physiology!
We show that pyridoxamine reduces inflammation and microcirculatory dysfunction in MASH, modulating key hepatic AGE/ALE signaling pathways.
🔗 doi.org/10.3389/fphy...
#MASH #LiverDisease #Inflammation
We show that pyridoxamine reduces inflammation and microcirculatory dysfunction in MASH, modulating key hepatic AGE/ALE signaling pathways.
🔗 doi.org/10.3389/fphy...
#MASH #LiverDisease #Inflammation
At the dawn of 2025, I received the second notification this week of an accepted manuscript.
A wonderful way to close out 2025 and step into 2026 with renewed motivation and momentum.
I wish everyone a Happy New Year and all the very best for the year ahead!
A wonderful way to close out 2025 and step into 2026 with renewed motivation and momentum.
I wish everyone a Happy New Year and all the very best for the year ahead!
December 31, 2025 at 4:43 PM
At the dawn of 2025, I received the second notification this week of an accepted manuscript.
A wonderful way to close out 2025 and step into 2026 with renewed motivation and momentum.
I wish everyone a Happy New Year and all the very best for the year ahead!
A wonderful way to close out 2025 and step into 2026 with renewed motivation and momentum.
I wish everyone a Happy New Year and all the very best for the year ahead!
Reposted by Kristiaan Wouters
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter, Greter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
December 3, 2025 at 6:00 PM
Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter, Greter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...
Today I presented our data on sex differences in experimental #MASH development at the MASLD-EGIR Study group meeting in Pisa showing earlier #steatosis, #inflammation and glucose intolerance in females but more fibrosis in males. Great conference! @gastaldelli-amy.bsky.social
December 3, 2025 at 11:23 AM
Today I presented our data on sex differences in experimental #MASH development at the MASLD-EGIR Study group meeting in Pisa showing earlier #steatosis, #inflammation and glucose intolerance in females but more fibrosis in males. Great conference! @gastaldelli-amy.bsky.social
Thrilled and honoured to chair the #VeniVidiVici session at #CARIMday2025! It's inspiring to see so many talented researchers achieving success in securing grants. Especially proud to serve as Chair of the Carim Research Council and witness this incredible progress! 👏🎉 @carimmaastricht.bsky.social
November 26, 2025 at 9:04 AM
Thrilled and honoured to chair the #VeniVidiVici session at #CARIMday2025! It's inspiring to see so many talented researchers achieving success in securing grants. Especially proud to serve as Chair of the Carim Research Council and witness this incredible progress! 👏🎉 @carimmaastricht.bsky.social
Reposted by Kristiaan Wouters
@sabinedaemen.bsky.social investigates how immune cells can repair liver fibrosis. A big step toward fighting one of the world’s most pressing metabolic diseases and emerging CVD risk factor.
#CARIMday2025 #MASLD #Veni
#CARIMday2025 #MASLD #Veni
November 26, 2025 at 8:40 AM
@sabinedaemen.bsky.social investigates how immune cells can repair liver fibrosis. A big step toward fighting one of the world’s most pressing metabolic diseases and emerging CVD risk factor.
#CARIMday2025 #MASLD #Veni
#CARIMday2025 #MASLD #Veni
Reposted by Kristiaan Wouters
Join now on www.youtube.com/live/17cD_lN... for our annual CARIM+HVC Symposium
CARIM+HVC Symposium 2025
YouTube video by Maastricht University
www.youtube.com
November 26, 2025 at 8:30 AM
Join now on www.youtube.com/live/17cD_lN... for our annual CARIM+HVC Symposium
Reposted by Kristiaan Wouters
@tilman-hackeng.bsky.social kicks off the #CARIMday2025. It will be a great day to celebrate #Cardiovascular research and working together.
November 26, 2025 at 8:33 AM
@tilman-hackeng.bsky.social kicks off the #CARIMday2025. It will be a great day to celebrate #Cardiovascular research and working together.
At the #ADDRM, @sabinedaemen.bsky.social, postdoc in my group, presented her work on sex differences in a mouse model of #MASH, an area where most data still rely on male mice. She found sex-specific differences in hepatic steatosis, fibrosis progression, and glucose intolerance.👏🐭🔬
November 14, 2025 at 6:11 PM
At the #ADDRM, @sabinedaemen.bsky.social, postdoc in my group, presented her work on sex differences in a mouse model of #MASH, an area where most data still rely on male mice. She found sex-specific differences in hepatic steatosis, fibrosis progression, and glucose intolerance.👏🐭🔬
Reposted by Kristiaan Wouters
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
Reposted by Kristiaan Wouters
Kicked off the #EU-RESOLVE COST Action last week - a network advancing research on #inflammation #resolution
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
October 17, 2025 at 4:58 PM
Kicked off the #EU-RESOLVE COST Action last week - a network advancing research on #inflammation #resolution
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
Kicked off the #EU-RESOLVE COST Action last week - a network advancing research on #inflammation #resolution
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
October 17, 2025 at 4:58 PM
Kicked off the #EU-RESOLVE COST Action last week - a network advancing research on #inflammation #resolution
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
I co-lead WG5, building a Knowledge Hub on insights in resolution biology. We want this hub to grow, so join us and help shape this valuable resource!
www.cost.eu/actions/CA24138/
Reposted by Kristiaan Wouters
#thesisdefence Tomorrow, Sara D'Haese will defend the thesis 'Mitigating diabetic cardiomyopathy: Evaluating exercise training and pyridoxamine as cardioprotective approaches’ at 16:00h @maastrichtu.bsky.social @kwouters.bsky.social
📺 buff.ly/1VrmD4j
📖
#phdlife #phddefence #GradSchool #doctorate
📺 buff.ly/1VrmD4j
📖
#phdlife #phddefence #GradSchool #doctorate
June 16, 2025 at 6:36 AM
#thesisdefence Tomorrow, Sara D'Haese will defend the thesis 'Mitigating diabetic cardiomyopathy: Evaluating exercise training and pyridoxamine as cardioprotective approaches’ at 16:00h @maastrichtu.bsky.social @kwouters.bsky.social
📺 buff.ly/1VrmD4j
📖
#phdlife #phddefence #GradSchool #doctorate
📺 buff.ly/1VrmD4j
📖
#phdlife #phddefence #GradSchool #doctorate
What.A.Guy. Best advice and applicable to about everything. "Stop whining. What are You doing?" There will always be obstacles. @schwarzenegger.bsky.social www.bbc.com/news/videos/...
Schwarzenegger: Hey, stop whining, do something on climate change
The actor and activist was speaking to the BBC at a summit organised by his Climate Initiative.
www.bbc.com
June 7, 2025 at 11:50 AM
What.A.Guy. Best advice and applicable to about everything. "Stop whining. What are You doing?" There will always be obstacles. @schwarzenegger.bsky.social www.bbc.com/news/videos/...
Inspiring presentation of Gemma Figtree at #EASCongress2025 on treating #atherosclerosis as a disease rather than traditional risk factors, especially considering that 25% of MI patients show none of them.
May 5, 2025 at 8:41 AM
Inspiring presentation of Gemma Figtree at #EASCongress2025 on treating #atherosclerosis as a disease rather than traditional risk factors, especially considering that 25% of MI patients show none of them.
#EASCongress2025 kicks off with a bang. Paul Ridker gives the Anitschkow lecture on targeting #inflammation to target #atherosclerosis. #cardiovascular #CVD
May 4, 2025 at 5:49 PM
#EASCongress2025 kicks off with a bang. Paul Ridker gives the Anitschkow lecture on targeting #inflammation to target #atherosclerosis. #cardiovascular #CVD
Kudos @GCN for a balanced analysis on claims that #exercise does not induce #weightloss: www.youtube.com/watch?v=vUGF...
As mentioned here (bjsm.bmj.com/content/59/2...) it's about adherence.
For me, first 20-25kg were dietary pattern changes (not dieting), the next few kg definitely exercise.
As mentioned here (bjsm.bmj.com/content/59/2...) it's about adherence.
For me, first 20-25kg were dietary pattern changes (not dieting), the next few kg definitely exercise.
The Biggest Lie About Weight Loss And Exercise
YouTube video by Global Cycling Network
www.youtube.com
January 16, 2025 at 1:35 PM
Kudos @GCN for a balanced analysis on claims that #exercise does not induce #weightloss: www.youtube.com/watch?v=vUGF...
As mentioned here (bjsm.bmj.com/content/59/2...) it's about adherence.
For me, first 20-25kg were dietary pattern changes (not dieting), the next few kg definitely exercise.
As mentioned here (bjsm.bmj.com/content/59/2...) it's about adherence.
For me, first 20-25kg were dietary pattern changes (not dieting), the next few kg definitely exercise.
Happy to share our latest publication showing that adiposity differentially affects immune cells in fat depots based on #sex during #obesity development. rdcu.be/d36Dx. @lisatschuetz.bsky.social al @biekebroux.bsky.social roux.bsky.social
#immunosky
#immunosky
Sex differentially affects pro-inflammatory cell subsets in adipose tissue depots in a diet induced obesity model
rdcu.be
December 19, 2024 at 8:12 AM
Happy to share our latest publication showing that adiposity differentially affects immune cells in fat depots based on #sex during #obesity development. rdcu.be/d36Dx. @lisatschuetz.bsky.social al @biekebroux.bsky.social roux.bsky.social
#immunosky
#immunosky
Reposted by Kristiaan Wouters
A review for those of us (me!) who only really know foamy macrophage in the context of cardiovascular pathology:
#immunology
journals.aai.org/jimmunol/art...
#immunology
journals.aai.org/jimmunol/art...
An Insight into the Role of IL-10 and Foamy Macrophages in Infectious Diseases
Abstract. Dysregulation of lipid homeostasis causes the deposition of lipids in the form of tiny droplets within foamy macrophages (FMs). In FMs, host-deri
journals.aai.org
December 6, 2024 at 7:33 AM
A review for those of us (me!) who only really know foamy macrophage in the context of cardiovascular pathology:
#immunology
journals.aai.org/jimmunol/art...
#immunology
journals.aai.org/jimmunol/art...