Kristoffer H. Johansen
@krishaurum.bsky.social
Lundbeckfonden Postdoc Fellow @ DTU 🇩🇰
T cell Immunology | TCRs | high-throughput screens | CRISPR
T cell Immunology | TCRs | high-throughput screens | CRISPR
Reposted by Kristoffer H. Johansen
Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells https://www.biorxiv.org/content/10.1101/2025.11.01.686037v1
November 3, 2025 at 11:16 PM
Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells https://www.biorxiv.org/content/10.1101/2025.11.01.686037v1
Thanks for a lovely time in Cambridge - great to see you all again. Already looking forward to next time.
Great to welcome former PhD student, now Assistant Professor @krishaurum.bsky.social of the DTU back to the Department of Pathology. Excellent presentation on TIL TCRs, peptide-MHC complexes and his recent paper on AI-designed pMHC binders (artificial TCRs).
October 3, 2025 at 7:44 AM
Thanks for a lovely time in Cambridge - great to see you all again. Already looking forward to next time.
Our paper is now out with peer review!
This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved.
Read about it below in Tims breakdown!
This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved.
Read about it below in Tims breakdown!
Thrilled to announce our paper, "De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells," is officially out in @science.org!
We used generative AI to build a 'GPS' for immune cells to hunt cancer.
Read it here: doi.org/10.1126/scie...
We used generative AI to build a 'GPS' for immune cells to hunt cancer.
Read it here: doi.org/10.1126/scie...
July 24, 2025 at 8:33 PM
Our paper is now out with peer review!
This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved.
Read about it below in Tims breakdown!
This was such a fast paced and fun project to be involved in and thanks to all the co-authors involved.
Read about it below in Tims breakdown!
Reposted by Kristoffer H. Johansen
It's not the models, it's the data!
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
A functionally validated TCR-pMHC database for TCR specificity model development
Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...
www.biorxiv.org
May 2, 2025 at 3:57 PM
It's not the models, it's the data!
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...