Dr Ksenia G. Kolobynina
@kkolobynina.bsky.social
Researcher in Cardoso lab at the Technical University Darmstadt, Germany
Passionate about chromatin, epigenetics, DNA repair and aging
Microscopy specialist
She/her
Opinions are my own
Passionate about chromatin, epigenetics, DNA repair and aging
Microscopy specialist
She/her
Opinions are my own
Reposted by Dr Ksenia G. Kolobynina
Different perspectives on epigenetic dynamics and memory, especially before genome replication:
We show H3K36me3 is dynamically enriched at pericentromeric heterochromatin (PCH) before its replication and erased after, tightly linking epigenetics and replication timing. doi.org/10.1038/s443...
We show H3K36me3 is dynamically enriched at pericentromeric heterochromatin (PCH) before its replication and erased after, tightly linking epigenetics and replication timing. doi.org/10.1038/s443...
September 10, 2025 at 8:50 AM
Different perspectives on epigenetic dynamics and memory, especially before genome replication:
We show H3K36me3 is dynamically enriched at pericentromeric heterochromatin (PCH) before its replication and erased after, tightly linking epigenetics and replication timing. doi.org/10.1038/s443...
We show H3K36me3 is dynamically enriched at pericentromeric heterochromatin (PCH) before its replication and erased after, tightly linking epigenetics and replication timing. doi.org/10.1038/s443...
Reposted by Dr Ksenia G. Kolobynina
To probe the role of H3K36me3 at PCH, we developed a new approach:
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
September 10, 2025 at 8:50 AM
To probe the role of H3K36me3 at PCH, we developed a new approach:
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
Creative handcrafted version of the replication patterns observed in mouse ES cells: the nuclei with chromocenters (bright blue) and replication foci marked by EdU (red beads). It already made its way to a PhD graduation hat ☺️🧑🎓
February 4, 2025 at 1:18 PM
Creative handcrafted version of the replication patterns observed in mouse ES cells: the nuclei with chromocenters (bright blue) and replication foci marked by EdU (red beads). It already made its way to a PhD graduation hat ☺️🧑🎓
Reposted by Dr Ksenia G. Kolobynina
EMBL green news!! ♻️
Registrations are open for our first Sustainable Research Symposium – together, we can reduce ecological footprint and ensure the viability of scientific research.
Join us to discuss and identify solutions for sustainable science:
www.embl.org/about/info/s...
Registrations are open for our first Sustainable Research Symposium – together, we can reduce ecological footprint and ensure the viability of scientific research.
Join us to discuss and identify solutions for sustainable science:
www.embl.org/about/info/s...
January 30, 2025 at 3:18 PM
EMBL green news!! ♻️
Registrations are open for our first Sustainable Research Symposium – together, we can reduce ecological footprint and ensure the viability of scientific research.
Join us to discuss and identify solutions for sustainable science:
www.embl.org/about/info/s...
Registrations are open for our first Sustainable Research Symposium – together, we can reduce ecological footprint and ensure the viability of scientific research.
Join us to discuss and identify solutions for sustainable science:
www.embl.org/about/info/s...