Dr Ksenia G. Kolobynina
@kkolobynina.bsky.social
Researcher in Cardoso lab at the Technical University Darmstadt, Germany
Passionate about chromatin, epigenetics, DNA repair and aging
Microscopy specialist
She/her
Opinions are my own
Passionate about chromatin, epigenetics, DNA repair and aging
Microscopy specialist
She/her
Opinions are my own
Reposted by Dr Ksenia G. Kolobynina
To probe the role of H3K36me3 at PCH, we developed a new approach:
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
September 10, 2025 at 8:50 AM
To probe the role of H3K36me3 at PCH, we developed a new approach:
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.
✨ Nanobody-mediated targeting of oncohistone H3.1 K36M directly to pericentromeric heterochromatin.
This locally reduced H3K36me3 without altering other histone modifications, and elsewhere in the chromatin.