Shubhangini Kataruka
@kataruka.bsky.social
Postdoc @ Lesch lab, Yale University.
Former @ svobodalab.bsky.social
Embryo, chromatin, epigenetics and reproduction.
Former @ svobodalab.bsky.social
Embryo, chromatin, epigenetics and reproduction.
Reposted by Shubhangini Kataruka
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
Truly a team effort from the Lesch lab @ambystoma22.bsky.social Happy to share this paper where we study the role of Smarca5 in spermatogenesis.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals | PNAS
Establishment of correct chromatin configuration in male meiosis is essential for
sperm formation and male fertility. However, how chromatin remode...
www.pnas.org
August 1, 2025 at 6:05 PM
Truly a team effort from the Lesch lab @ambystoma22.bsky.social Happy to share this paper where we study the role of Smarca5 in spermatogenesis.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
So excited to be part of this exceptional group of scientists!
We are thrilled to announce the 2025 Leading Edge Fellows! 40 outstanding postdoctoral fellows doing pioneering research in a wide range of biological and biomedical disciplines.
Learn more about these exceptional scientists:
www.leadingedgesymposium.org/fellows
Learn more about these exceptional scientists:
www.leadingedgesymposium.org/fellows
May 27, 2025 at 6:45 PM
So excited to be part of this exceptional group of scientists!