@karthid90.bsky.social
PhD Student in Integrative structural biology on RNA-binding proteins.
#crystallography #SAXS #NMR #RNA #biophysics #biochemistry #structuralbiology
#crystallography #SAXS #NMR #RNA #biophysics #biochemistry #structuralbiology
Pinned
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding - Nature Communications
The authors use solution-state NMR and X-ray crystallography to study mutations in the SARS-CoV-2 Nucleocapsid NTD, uncovering a network essential for protein integrity and the selectively of RNA bind...
www.nature.com
Our work on how a conserved core network in the SARS-CoV-2 nucleocapsid NTD affects stability, RNA-binding affinity, and selectivity of the domain is now online.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
1/n Very excited to share my lab's latest manuscript, 3 years after I started my independent group! This was a fantastic collaboration with Bryan Johnson and @themenacherylab.bsky.social , led by joint 1st authors Hannah Kubinski and Hannah Despres in my lab www.biorxiv.org/content/10.1...
Variant mutation in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
March 12, 2024 at 1:54 PM
1/n Very excited to share my lab's latest manuscript, 3 years after I started my independent group! This was a fantastic collaboration with Bryan Johnson and @themenacherylab.bsky.social , led by joint 1st authors Hannah Kubinski and Hannah Despres in my lab www.biorxiv.org/content/10.1...
Reposted
biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…
March 26, 2025 at 5:13 AM
biorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…
Reposted
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 2, 2025 at 5:59 PM
Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
Congratulations to our SPC facility user, Karthi Dhamotharan and the Schlundt Lab, for such an achievement on SARS-CoV-2 nucleocapsid protein and RNA binding 🦠🧬
Well done ! 👍
@embl.org @cssbhamburg.bsky.social
Well done ! 👍
@embl.org @cssbhamburg.bsky.social
December 13, 2024 at 12:01 PM
Congratulations to our SPC facility user, Karthi Dhamotharan and the Schlundt Lab, for such an achievement on SARS-CoV-2 nucleocapsid protein and RNA binding 🦠🧬
Well done ! 👍
@embl.org @cssbhamburg.bsky.social
Well done ! 👍
@embl.org @cssbhamburg.bsky.social
Our work on how a conserved core network in the SARS-CoV-2 nucleocapsid NTD affects stability, RNA-binding affinity, and selectivity of the domain is now online.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding - Nature Communications
The authors use solution-state NMR and X-ray crystallography to study mutations in the SARS-CoV-2 Nucleocapsid NTD, uncovering a network essential for protein integrity and the selectively of RNA bind...
www.nature.com
December 9, 2024 at 3:03 PM
Our work on how a conserved core network in the SARS-CoV-2 nucleocapsid NTD affects stability, RNA-binding affinity, and selectivity of the domain is now online.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
19 new SARS-CoV-2 structures this week, 696 this year (shown), for 4606 total available in the PDB.
Explore them all at rcsb.org/covid19
Explore them all at rcsb.org/covid19
November 20, 2024 at 5:08 PM
19 new SARS-CoV-2 structures this week, 696 this year (shown), for 4606 total available in the PDB.
Explore them all at rcsb.org/covid19
Explore them all at rcsb.org/covid19