Karges Group
@kargesgroup.bsky.social
Liebig Fellow Group Leader at Ruhr University Bochum, Laboratory for Medicinal Inorganic Chemistry
https://www.kargesgroup.ruhr-uni-bochum.de/
https://www.kargesgroup.ruhr-uni-bochum.de/
Reposted by Karges Group
Happy to see this collaborative with Hui Chao and @kargesgroup.bsky.social out in @angewandtechemie.bsky.social. We designed Ir(III) complexes to trigger oncosis and activate the cyclic GMP–AMP synthase-stimulator of interferon genes pathway.
@chimieparistechpsl.bsky.social
doi.org/10.1002/anie...
@chimieparistechpsl.bsky.social
doi.org/10.1002/anie...
December 9, 2025 at 2:16 AM
Happy to see this collaborative with Hui Chao and @kargesgroup.bsky.social out in @angewandtechemie.bsky.social. We designed Ir(III) complexes to trigger oncosis and activate the cyclic GMP–AMP synthase-stimulator of interferon genes pathway.
@chimieparistechpsl.bsky.social
doi.org/10.1002/anie...
@chimieparistechpsl.bsky.social
doi.org/10.1002/anie...
Incredibly proud to congratulate @antoniolinero.bsky.social on defending his PhD! He did a fantastic job. It’s been an honor to accompany him on this journey and to share this achievement with @joseruizlab.bsky.social, @vanesafm-isqch.bsky.social, @giampaolobarone.bsky.social and Dolores Santana. 🎉
After an outstanding PhD defence by @antoniolinero.bsky.social. we’re enjoying the best of Murcia with @joseruizlab.bsky.social , @giampaolobarone.bsky.social and @kargesgroup.bsky.social! Proud moment.
December 1, 2025 at 9:21 AM
Incredibly proud to congratulate @antoniolinero.bsky.social on defending his PhD! He did a fantastic job. It’s been an honor to accompany him on this journey and to share this achievement with @joseruizlab.bsky.social, @vanesafm-isqch.bsky.social, @giampaolobarone.bsky.social and Dolores Santana. 🎉
🎥 Honored to be featured in a TV interview with WDR! We talked about our research and its impact — full interview (in German) here 👉 at 14:55 min: www.ardmediathek.de/video/lokalz...
October 24, 2025 at 7:07 AM
🎥 Honored to be featured in a TV interview with WDR! We talked about our research and its impact — full interview (in German) here 👉 at 14:55 min: www.ardmediathek.de/video/lokalz...
Proud to share our new @ChemRxiv preprint. We report on a novel Metal-to-Metal Electron Transfer Mechanism enabling Hydroxyl Radical Photoredox Catalysis in Hypoxic and Drug-Resistant Cancer Cells, addressing bottlenecks in photodynamic therapy. Please RT! chemrxiv.org/engage/chemr...
October 15, 2025 at 7:04 AM
Proud to share our new @ChemRxiv preprint. We report on a novel Metal-to-Metal Electron Transfer Mechanism enabling Hydroxyl Radical Photoredox Catalysis in Hypoxic and Drug-Resistant Cancer Cells, addressing bottlenecks in photodynamic therapy. Please RT! chemrxiv.org/engage/chemr...
Check out our paper in @chemcomm.rsc.org about the Red-Light Excitation of Ru(II)-Pt(II) Tetranuclear Complex for Combined Photoactivated Chemotherapy and Photodynamic Therapy. Congrats to Pia, Eleni, Julia, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D5CC...
October 8, 2025 at 7:04 AM
Check out our paper in @chemcomm.rsc.org about the Red-Light Excitation of Ru(II)-Pt(II) Tetranuclear Complex for Combined Photoactivated Chemotherapy and Photodynamic Therapy. Congrats to Pia, Eleni, Julia, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D5CC...
🚨 PhD Opportunity! 🚨
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...
October 2, 2025 at 10:16 AM
🚨 PhD Opportunity! 🚨
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...
Join our group in Bioinorganic Chemistry to work on the synthesis & biological evaluation of metal complexes for anticancer therapy.
jobs.ruhr-uni-bochum.de/jobposting/8...
Check out our paper in @inorgchemfront.rsc.org about the Induction of Oncosis by Light Activation with an Ir(III) complex conjugated to Albumin. Congrats to Antonio, Zisis, and Lisa. Fantastic collaboration with @joseruizlab.bsky.social ! @ruhr-uni-bochum.de @um.es dx.doi.org/10.1039/D5QI...
July 29, 2025 at 2:01 PM
Check out our paper in @inorgchemfront.rsc.org about the Induction of Oncosis by Light Activation with an Ir(III) complex conjugated to Albumin. Congrats to Antonio, Zisis, and Lisa. Fantastic collaboration with @joseruizlab.bsky.social ! @ruhr-uni-bochum.de @um.es dx.doi.org/10.1039/D5QI...
Reposted by Karges Group
👉 Ein von der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de entwickelter neuer Wirkstoffkomplex tötet Krebszellen auf eine so geschickte Art, dass sie im Sterben dem #Immunsystem den Weg zu #Metastasen zeigt, die sich an entfernten Orten im Körper entwickeln.
Sterbende Tumorzellen machen Metastasen zur Zielscheibe
Ein neuer Wirkstoff kann Krebszellen beseitigen und gleichzeitig das Immunsystem trainieren, solche Zellen überall im Körper zu vernichten.
healthcare-in-europe.com
July 29, 2025 at 6:33 AM
👉 Ein von der @kargesgroup.bsky.social an der @ruhr-uni-bochum.de entwickelter neuer Wirkstoffkomplex tötet Krebszellen auf eine so geschickte Art, dass sie im Sterben dem #Immunsystem den Weg zu #Metastasen zeigt, die sich an entfernten Orten im Körper entwickeln.
Check out our paper in J. Med. Chem. @acsbiol.bsky.social @acsmedi.bsky.social about the induction of immunogenic cell death by a gallium complex for chemoimmunotherapy. Congrats to Zisis and Yassin! @ruhr-uni-bochum.de
dx.doi.org/10.1021/acs....
dx.doi.org/10.1021/acs....
July 18, 2025 at 6:09 AM
Check out our paper in J. Med. Chem. @acsbiol.bsky.social @acsmedi.bsky.social about the induction of immunogenic cell death by a gallium complex for chemoimmunotherapy. Congrats to Zisis and Yassin! @ruhr-uni-bochum.de
dx.doi.org/10.1021/acs....
dx.doi.org/10.1021/acs....
Wonderful presenting some of our research at Universidade Federal de Juiz de Fora @ufjfoficial.bsky.social Thanks to Luiz for the kind invitation! @ruhr-uni-bochum.de
June 6, 2025 at 5:01 PM
Wonderful presenting some of our research at Universidade Federal de Juiz de Fora @ufjfoficial.bsky.social Thanks to Luiz for the kind invitation! @ruhr-uni-bochum.de
Check out our study in @acsmedi.bsky.social about the "Induction of Cuproptosis with a Highly Cytotoxic Tripodal Cu(II) Complex". Congrats to Ricarda and @nmontesdeocas.bsky.social @ruhr-uni-bochum.de
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
June 4, 2025 at 9:54 AM
Check out our study in @acsmedi.bsky.social about the "Induction of Cuproptosis with a Highly Cytotoxic Tripodal Cu(II) Complex". Congrats to Ricarda and @nmontesdeocas.bsky.social @ruhr-uni-bochum.de
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Wonderful presenting some of our studies at the BioOpen Conference in beautiful Łódź as part of the UNIC network. @ruhr-uni-bochum.de
May 17, 2025 at 12:36 PM
Wonderful presenting some of our studies at the BioOpen Conference in beautiful Łódź as part of the UNIC network. @ruhr-uni-bochum.de
Check out our paper in @inorgchemfront.rsc.org about Utilizing Metal-Metal Electron Transfer in Dinuclear Photosensitizers for Exceptionally High ROS Production. Congrats to @juansanzvi.bsky.social @nmontesdeocas.bsky.social ! Wonderful collaboration with Gustavo Espino! dx.doi.org/10.1039/D5QI...
May 8, 2025 at 7:22 AM
Check out our paper in @inorgchemfront.rsc.org about Utilizing Metal-Metal Electron Transfer in Dinuclear Photosensitizers for Exceptionally High ROS Production. Congrats to @juansanzvi.bsky.social @nmontesdeocas.bsky.social ! Wonderful collaboration with Gustavo Espino! dx.doi.org/10.1039/D5QI...
Time for a new group picture 😉
May 6, 2025 at 11:48 AM
Time for a new group picture 😉
Check out our article in ACS Med. Chem. Lett. @acsmedi.bsky.social about the Induction of Ferroptosis with Au(I) NHC Complexes. Congrats to @nmontesdeocas.bsky.social . Great collaboration with Thomas Scattolin! @ruhr-uni-bochum.de dx.doi.org/10.1021/acsm...
April 28, 2025 at 10:57 AM
Check out our article in ACS Med. Chem. Lett. @acsmedi.bsky.social about the Induction of Ferroptosis with Au(I) NHC Complexes. Congrats to @nmontesdeocas.bsky.social . Great collaboration with Thomas Scattolin! @ruhr-uni-bochum.de dx.doi.org/10.1021/acsm...
Check out our Article in @daltontrans.rsc.org about the Synthesis and Photophysical Evaluation of an Aldehyde Bearing Ru(II) Complex as a Synthetic Precursor for Photodynamic Therapy. Congrats to Lisa, Hung, Nicolas, Zisis, and Eun! dx.doi.org/10.1039/D5DT...
April 3, 2025 at 8:52 AM
Check out our Article in @daltontrans.rsc.org about the Synthesis and Photophysical Evaluation of an Aldehyde Bearing Ru(II) Complex as a Synthetic Precursor for Photodynamic Therapy. Congrats to Lisa, Hung, Nicolas, Zisis, and Eun! dx.doi.org/10.1039/D5DT...
Congrats to Pia @psiekierski.bsky.social for receiving the Poster Award of the 19th Ferrocene Colloquium! 🎉
April 1, 2025 at 1:58 PM
Congrats to Pia @psiekierski.bsky.social for receiving the Poster Award of the 19th Ferrocene Colloquium! 🎉
Wonderful welcoming you to Bochum and thanks for a fantastic presentation about recent progress in PDT!
It was a great pleasure to present our latest results onPDT at the excellent 19th Ferrocene Colloquium at RUB University (Bochum, Germany). Many thanks to the organizers, @NMNLab & @viktoriagessner.bsky.social for the invitation. Thank you also @kargesgroup.bsky.social for the nice collaboration.
April 1, 2025 at 9:03 AM
Wonderful welcoming you to Bochum and thanks for a fantastic presentation about recent progress in PDT!
Check out our article in J. Med. Chem. @acsmedi.bsky.social about the Rational Design of an Ir(III) Complex with Exceptionally Strong Human Serum Albumin Binding for Photodynamic Therapy. Congrats to Antonio & Lisa! Wonderful collaboration with @joseruizlab.bsky.social ! pubs.acs.org/doi/full/10....
March 21, 2025 at 8:47 AM
Check out our article in J. Med. Chem. @acsmedi.bsky.social about the Rational Design of an Ir(III) Complex with Exceptionally Strong Human Serum Albumin Binding for Photodynamic Therapy. Congrats to Antonio & Lisa! Wonderful collaboration with @joseruizlab.bsky.social ! pubs.acs.org/doi/full/10....
Reposted by Karges Group
A novel arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent - now published in InorgChemFront in collaboration with Viktor Brabec pubs.rsc.org/en/content/a... Congrats to all the co-authors.
A novel benzothiazole-1,2,3-triazole-based arene osmium(II) complex as an effective rhabdomyosarcoma cancer stem cell agent
We designed a series of pseudo-octahedral arene Os(ii) complexes (Os1–Os5) with the general formula [(η6-p-cym)Os(BTAT)Cl]+, where BTAT represents chelating N^N′ ligands based on the 1-aryl-4-benzothi...
pubs.rsc.org
January 17, 2025 at 7:00 PM
A novel arene osmium(ii) complex as an effective rhabdomyosarcoma cancer stem cell agent - now published in InorgChemFront in collaboration with Viktor Brabec pubs.rsc.org/en/content/a... Congrats to all the co-authors.
Reposted by Karges Group
Our Minireview on the growing field of combinatorial metal complex synthesis is now out! onlinelibrary.wiley.com/doi/full/10....
High‐Throughput Combinatorial Metal Complex Synthesis
This minireview explores advancements in high-throughput combinatorial synthesis of metal complexes, emphasising their applications in catalysis, drug discovery, and materials science. We highlight v...
onlinelibrary.wiley.com
January 14, 2025 at 12:44 PM
Our Minireview on the growing field of combinatorial metal complex synthesis is now out! onlinelibrary.wiley.com/doi/full/10....
Wonderful seeing our cover on the recent issue of @daltontrans.bsky.social ! Check out the full article here: dx.doi.org/10.1039/D4DT...
January 14, 2025 at 6:25 PM
Wonderful seeing our cover on the recent issue of @daltontrans.bsky.social ! Check out the full article here: dx.doi.org/10.1039/D4DT...
Check out our paper in Small about utilizing the Excited Intramolecular Proton‐Coupled Electron Transfer in a Dinuclear Ir(III) Complex for Photodynamic Therapy. Congrats to Maniklal, Julia, Nishith, Gourav and @nmontesdeocas.bsky.social ! onlinelibrary.wiley.com/doi/10.1002/...
December 26, 2024 at 10:31 AM
Check out our paper in Small about utilizing the Excited Intramolecular Proton‐Coupled Electron Transfer in a Dinuclear Ir(III) Complex for Photodynamic Therapy. Congrats to Maniklal, Julia, Nishith, Gourav and @nmontesdeocas.bsky.social ! onlinelibrary.wiley.com/doi/10.1002/...
Check out our article in Dalton Trans. about a Necrosis Inducing Tetranuclear Ru(II)-Re(I) complex for Anticancer Therapy. Congrats to Julia, Eleni, Stephan, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D4DT...
December 18, 2024 at 1:54 PM
Check out our article in Dalton Trans. about a Necrosis Inducing Tetranuclear Ru(II)-Re(I) complex for Anticancer Therapy. Congrats to Julia, Eleni, Stephan, and @nmontesdeocas.bsky.social ! @ruhr-uni-bochum.de dx.doi.org/10.1039/D4DT...