Kai Pohl
@kaipohl.bsky.social
Postdoc in translational vaccine research @Charité - University Medical Center, Berlin. PhD from JCSMR @ANU, Canberra. Interested in Innate immunity and T cells. Mostly here for science and some politics.
Reposted by Kai Pohl
Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells https://www.biorxiv.org/content/10.1101/2025.10.19.682634v1
October 20, 2025 at 3:15 AM
Precision targeting of autoreactive B cells in systemic lupus erythematosus using anti-9G4 idiotope synthetic immune receptor T cells https://www.biorxiv.org/content/10.1101/2025.10.19.682634v1
Reposted by Kai Pohl
If leaders are serious about ending war, women need a seat at the table.
Global data, 1989-2011: When women are involved in agreements, peace is 35% more likely to last 15+ years.
Men alone shouldn’t decide the fate of nations. Gender balance is especially vital with high stakes and hot tempers.
Global data, 1989-2011: When women are involved in agreements, peace is 35% more likely to last 15+ years.
Men alone shouldn’t decide the fate of nations. Gender balance is especially vital with high stakes and hot tempers.
March 1, 2025 at 8:39 PM
If leaders are serious about ending war, women need a seat at the table.
Global data, 1989-2011: When women are involved in agreements, peace is 35% more likely to last 15+ years.
Men alone shouldn’t decide the fate of nations. Gender balance is especially vital with high stakes and hot tempers.
Global data, 1989-2011: When women are involved in agreements, peace is 35% more likely to last 15+ years.
Men alone shouldn’t decide the fate of nations. Gender balance is especially vital with high stakes and hot tempers.
Reposted by Kai Pohl
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
November 19, 2024 at 12:27 PM
The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on?
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
direct.mit.edu/qss/article/...
A 🧵 1/n
#AcademicSky #PhDchat #ScientificPublishing #SciPub
🤯
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 10:53 PM
🤯
Reposted by Kai Pohl
Did you know that Germany has its own large-scale population-based biobank?
The German National Cohort or NAKO❗
If not, let me tell you why👇
The German National Cohort or NAKO❗
If not, let me tell you why👇
December 1, 2024 at 5:04 PM
Did you know that Germany has its own large-scale population-based biobank?
The German National Cohort or NAKO❗
If not, let me tell you why👇
The German National Cohort or NAKO❗
If not, let me tell you why👇
Reposted by Kai Pohl
To get the ball rolling here on Bsky I'll post this recent preprint that I never posted on X because... you know... ick.
We find that B cells take bites out of parasites to obtain antigens for presentation to T cells.
www.biorxiv.org/content/10.1...
We find that B cells take bites out of parasites to obtain antigens for presentation to T cells.
www.biorxiv.org/content/10.1...
B cells targeting parasites capture spatially linked antigens to secure T cell help
Our understanding of T-cell-dependent humoral responses has been largely shaped by studies involving model antigens such as recombinant proteins and viruses [1][1],[2][2]. In these contexts, B cells i...
www.biorxiv.org
November 21, 2024 at 9:49 PM
To get the ball rolling here on Bsky I'll post this recent preprint that I never posted on X because... you know... ick.
We find that B cells take bites out of parasites to obtain antigens for presentation to T cells.
www.biorxiv.org/content/10.1...
We find that B cells take bites out of parasites to obtain antigens for presentation to T cells.
www.biorxiv.org/content/10.1...
Reposted by Kai Pohl
My first Skeetorial!
💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem.
TLDR:
We pretrained LLMs on ~8M TCR & pMHC seqs
Finetuned on sparse pMHC->TCR pair data
Validated CDR3b sequences to unseen antigens
>> random performance on IMMREP2023 "private" antigens
💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem.
TLDR:
We pretrained LLMs on ~8M TCR & pMHC seqs
Finetuned on sparse pMHC->TCR pair data
Validated CDR3b sequences to unseen antigens
>> random performance on IMMREP2023 "private" antigens
November 19, 2024 at 6:54 PM
My first Skeetorial!
💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem.
TLDR:
We pretrained LLMs on ~8M TCR & pMHC seqs
Finetuned on sparse pMHC->TCR pair data
Validated CDR3b sequences to unseen antigens
>> random performance on IMMREP2023 "private" antigens
💻🧬TCR-TRANSLATE - A new framework for thinking about the TCR:pMHC specificity problem.
TLDR:
We pretrained LLMs on ~8M TCR & pMHC seqs
Finetuned on sparse pMHC->TCR pair data
Validated CDR3b sequences to unseen antigens
>> random performance on IMMREP2023 "private" antigens
Reposted by Kai Pohl
Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...
Tissue determinants of the human T cell receptor repertoire
98% of T cells reside in tissues, yet nearly all human T cell analyses are performed from peripheral blood. We single-cell sequenced 5.7 million T cells from ten donors’ autologous blood and tonsils a...
www.biorxiv.org
November 15, 2024 at 2:13 PM
Here is out first attempt to understand #TCR #repertoire in human tissues -Tissue determinants of the human T cell receptor repertoire Around 6 million T cells profiled at #single #cell #level www.biorxiv.org/content/10.1...
Reposted by Kai Pohl
LLMs are fantastic learners of arbitrary sequence to sequence mappings. Text summarization, Q&A, and machine translation, etc. So what happens if you apply them to the many-to-many mapping of the TCR cross reactivity landscape? Turns out, some pretty cool things. Check it out 😏
New de-novo TCR design preprint from @dkarthikey1.bsky.social just dropped:
TCR-TRANSLATE: Conditional Generation of Real Antigen Specific T-cell Receptor Sequences
www.biorxiv.org/content/10.1...
TCR-TRANSLATE: Conditional Generation of Real Antigen Specific T-cell Receptor Sequences
www.biorxiv.org/content/10.1...
November 13, 2024 at 12:08 PM
LLMs are fantastic learners of arbitrary sequence to sequence mappings. Text summarization, Q&A, and machine translation, etc. So what happens if you apply them to the many-to-many mapping of the TCR cross reactivity landscape? Turns out, some pretty cool things. Check it out 😏