Junji Xing
@junjixing.bsky.social
Assistant Professor at Houston Methodist Academic Institute and Weill Cornell Medicine of Cornell University
Antiviral innate immune sensing, regulation, and viral immune evasion
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social @innateimmunity.bsky.social
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social @innateimmunity.bsky.social
Frontiers | Editorial: Antiviral innate immune sensing, regulation, and viral immune evasion
Antiviral innate immune response represents a critical line of defense against viral infections, encompassing sensing and responding to viruses (1,2). Centra...
www.frontiersin.org
September 18, 2025 at 11:10 PM
Antiviral innate immune sensing, regulation, and viral immune evasion
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social @innateimmunity.bsky.social
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social @innateimmunity.bsky.social
antiviral innate immune sensing, regulation, and viral immune evasion
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social
Frontiers | Editorial: Community series in antiviral innate immune sensing, regulation, and viral immune evasion: volume II
Innate immunity is the cellular host's frontline defense against viral infections. It employs pattern recognition receptors (PRRs) to detect viral nucleo...
www.frontiersin.org
September 18, 2025 at 11:08 PM
antiviral innate immune sensing, regulation, and viral immune evasion
www.frontiersin.org/journals/imm... @frontiersmedia.bsky.social
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Plasticity and metabolic switching in adipose tissue macrophages
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www.frontiersin.org/journals/imm... @kingmacrophage.bsky.social
Frontiers | Editorial: Plasticity and metabolic switching in adipose tissue macrophages
Macrophages are frontier soldiers of innate immunity. Adipose tissue macrophages (ATMs), originally identified by the expression of the macrophage marker F4/...
www.frontiersin.org
September 18, 2025 at 11:07 PM
Plasticity and metabolic switching in adipose tissue macrophages
www.frontiersin.org/journals/imm... @kingmacrophage.bsky.social
www.frontiersin.org/journals/imm... @kingmacrophage.bsky.social
Mechanisms involved in controlling RNA virus-induced intestinal inflammation
link.springer.com/article/10.1... @springernature.com
link.springer.com/article/10.1... @springernature.com
Mechanisms involved in controlling RNA virus-induced intestinal inflammation - Cellular and Molecular Life Sciences
Gastroenteritis is inflammation of the lining of stomach and intestines and causes significant morbidity and mortality worldwide. Many viruses, especially RNA viruses are the most common cause of ente...
link.springer.com
September 18, 2025 at 11:06 PM
Mechanisms involved in controlling RNA virus-induced intestinal inflammation
link.springer.com/article/10.1... @springernature.com
link.springer.com/article/10.1... @springernature.com
Sensing DNA in Antiviral Innate Immunity
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Frontiers | Editorial: Sensing DNA in Antiviral Innate Immunity
The editorial team welcomes you to the specific Research Topic on "Sensing DNA in Antiviral Innate Immunity". We appreciate the hard work and outst...
www.frontiersin.org
September 18, 2025 at 11:04 PM
Sensing DNA in Antiviral Innate Immunity
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Granulysin Production and Anticryptococcal Activity Is Dependent upon a Far Upstream Enhancer That Binds STAT5 in Human Peripheral Blood CD4+ T Cells url: academic.oup.com/jimmunol/art... @jimmunol.bsky.social
Granulysin Production and Anticryptococcal Activity Is Dependent upon a Far Upstream Enhancer That Binds STAT5 in Human Peripheral Blood CD4+ T Cells
Abstract. Previous studies have demonstrated that STAT5 is critical for expression of granulysin and antimicrobial activity. Because the signaling pathway
academic.oup.com
September 18, 2025 at 11:01 PM
Granulysin Production and Anticryptococcal Activity Is Dependent upon a Far Upstream Enhancer That Binds STAT5 in Human Peripheral Blood CD4+ T Cells url: academic.oup.com/jimmunol/art... @jimmunol.bsky.social
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus url: academic.oup.com/jimmunol/art... @jimmunol.bsky.social @innateimmunity.bsky.social
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus
Abstract. The innate immunity is critically important in protection against virus infections, and in the case of RNA viral infections, the signaling mechan
academic.oup.com
September 18, 2025 at 10:58 PM
TRIM29 Negatively Regulates the Type I IFN Production in Response to RNA Virus url: academic.oup.com/jimmunol/art... @jimmunol.bsky.social @innateimmunity.bsky.social
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @kingmacrophage.bsky.social
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain | Journal of Virology
ABSTRACT Several arenavirus pathogens, such as Lassa and Junin viruses, inhibit macrophage
activation, the molecular mechanism of which is unclear. We show that lymphocytic
choriomeningitis virus (LCM...
journals.asm.org
September 18, 2025 at 10:55 PM
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @kingmacrophage.bsky.social
The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon Production | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @innateimmunity.bsky.social
The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon Production | Journal of Virology
ABSTRACT Arenavirus pathogens cause a wide spectrum of diseases in humans ranging from central nervous system disease to lethal hemorrhagic fevers with few treatment options. The reason why some arenaviruses can cause severe human diseases while others ...
journals.asm.org
September 18, 2025 at 10:54 PM
The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon Production | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @innateimmunity.bsky.social
Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @herpesadvocate.bsky.social
Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP | Journal of Virology
ABSTRACT Host cells activate innate immune signaling pathways to defend against invading pathogens. To survive within an infected host, viruses have evolved intricate strategies to counteract host immune responses. Herpesviruses, including herpes simplex ...
journals.asm.org
September 18, 2025 at 10:52 PM
Herpes Simplex Virus 1-Encoded Tegument Protein VP16 Abrogates the Production of Beta Interferon (IFN) by Inhibiting NF-κB Activation and Blocking IFN Regulatory Factor 3 To Recruit Its Coactivator CBP | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @herpesadvocate.bsky.social
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5 | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @herpesadvocate.bsky.social
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5 | Journal of Virology
ABSTRACT The interferon (IFN)-mediated antiviral response is a major defense of the host immune
system. In order to complete their life cycle, viruses must modulate host IFN-mediated
immune responses....
journals.asm.org
September 18, 2025 at 10:50 PM
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5 | Journal of Virology journals.asm.org/doi/10.1128/... @asm.org @herpesadvocate.bsky.social
Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells
link.springer.com/article/10.1... @springernature.com
link.springer.com/article/10.1... @springernature.com
Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells - Medical Microbiology and Immunology
In this study, we presented the construction of a library of expression clones for the herpes simplex virus type 1 (HSV-1) proteome and subcellular localization map of HSV-1 proteins in living cells u...
link.springer.com
September 18, 2025 at 10:48 PM
Characterization of the subcellular localization of herpes simplex virus type 1 proteins in living cells
link.springer.com/article/10.1... @springernature.com
link.springer.com/article/10.1... @springernature.com
Comprehensive Characterization of Interaction Complexes of Herpes Simplex Virus Type 1 ICP22, UL3, UL4, and UL20.5 | Journal of Virology @asm.org @herpesadvocate.bsky.social journals.asm.org/doi/10.1128/...
Comprehensive Characterization of Interaction Complexes of Herpes Simplex Virus Type 1 ICP22, UL3, UL4, and UL20.5
| Journal of Virology
ABSTRACT
It has been reported that herpes simplex virus type 1 UL3, UL4, and UL20.5 proteins
are localized to small, dense nuclear bodies together with ICP22 in infected cells.
In the present study, w...
journals.asm.org
September 18, 2025 at 10:47 PM
Comprehensive Characterization of Interaction Complexes of Herpes Simplex Virus Type 1 ICP22, UL3, UL4, and UL20.5 | Journal of Virology @asm.org @herpesadvocate.bsky.social journals.asm.org/doi/10.1128/...
Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells
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www.sciencedirect.com/science/arti... @elsevierconnect.bsky.social @elsevierhms.bsky.social
Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells
The herpes simplex virus type I (HSV-1) US11 protein is an RNA-binding multifunctional regulator that specifically and stably associates with nucleoli…
www.sciencedirect.com
September 18, 2025 at 10:44 PM
Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells
www.sciencedirect.com/science/arti... @elsevierconnect.bsky.social @elsevierhms.bsky.social
www.sciencedirect.com/science/arti... @elsevierconnect.bsky.social @elsevierhms.bsky.social
Identification of a novel linear B-cell epitope in the M protein of avian infectious bronchitis coronaviruses link.springer.com/article/10.1... @springernature.com
Identification of a novel linear B-cell epitope in the M protein of avian infectious bronchitis coronaviruses - Journal of Microbiology
This report describes the identification of a novel linear B-cell epitope at the C-terminus of the membrane (M) protein of avian infectious bronchitis virus (IBV). A monoclonal antibody (MAb) (designa...
link.springer.com
September 18, 2025 at 10:40 PM
Identification of a novel linear B-cell epitope in the M protein of avian infectious bronchitis coronaviruses link.springer.com/article/10.1... @springernature.com
Our latest review paper on innate immunity and Herpes Simplex Keratitis has just been published in Frontiers in Immunology www.frontiersin.org/journals/imm...
Frontiers | Tug of war: innate immunity and herpes simplex keratitis
Herpes simplex keratitis (HSK), caused by herpes simplex virus type I (HSV-1) ocular infection, is a leading cause of visual morbidity worldwide, and althoug...
www.frontiersin.org
August 30, 2025 at 3:55 AM
Our latest review paper on innate immunity and Herpes Simplex Keratitis has just been published in Frontiers in Immunology www.frontiersin.org/journals/imm...
Thrilled to share our editorial on regulation of antiviral and antimicrobial innate immunity and immune evasion is officially published with @springernature.com in Cellular and Molecular Life Sciences link.springer.com/article/10.1...
Regulation of antiviral and antimicrobial innate immunity and immune evasion - Cellular and Molecular Life Sciences
The interplay between host innate immunity and pathogen evasion is a dynamic battle shaping infection outcomes. The Topical Collection “Regulation of Antiviral and Antimicrobial Innate Immunity and Im...
link.springer.com
August 30, 2025 at 3:20 AM
Thrilled to share our editorial on regulation of antiviral and antimicrobial innate immunity and immune evasion is officially published with @springernature.com in Cellular and Molecular Life Sciences link.springer.com/article/10.1...
Thrilled to share our new review about therapeutic landscape of ovarian cancer is officially out in Biomarker Research journal! 📢 A huge thanks to the team! 🙌 Read it here: biomarkerres.biomedcentral.com/articles/10.... #OvarianCancer #CancerResearch #CancerandCardiovascularDisease
Therapeutic landscape of ovarian cancer: recent advances and emerging therapies - Biomarker Research
Ovarian cancer ranks as the seventh most common malignancy and the eighth leading cause of cancer-related death in women worldwide. Most patients are diagnosed at an advanced stage, resulting in poor ...
biomarkerres.biomedcentral.com
August 13, 2025 at 4:05 AM
Thrilled to share our new review about therapeutic landscape of ovarian cancer is officially out in Biomarker Research journal! 📢 A huge thanks to the team! 🙌 Read it here: biomarkerres.biomedcentral.com/articles/10.... #OvarianCancer #CancerResearch #CancerandCardiovascularDisease
Reposted by Junji Xing
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage
Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...
www.science.org
July 11, 2025 at 1:03 AM
🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...
Today, I received best Christmas gift: I just reached 1,800 citations on Google Scholar! My H-index on Google Scholar has now hit 24. I’m incredibly grateful to my mentors, lab members, and collaborators who made this milestone possible! Wish everyone a joyful and peaceful Christmas!
rdcu.be/d4N0R
rdcu.be/d4N0R
December 25, 2024 at 11:04 PM
Today, I received best Christmas gift: I just reached 1,800 citations on Google Scholar! My H-index on Google Scholar has now hit 24. I’m incredibly grateful to my mentors, lab members, and collaborators who made this milestone possible! Wish everyone a joyful and peaceful Christmas!
rdcu.be/d4N0R
rdcu.be/d4N0R
Happy to share that we identified TRIM18 as a critical regulator of viral myocarditis and organ inflammation in Journal of Biomedical Science
@natureportfolio.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
@natureportfolio.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
TRIM18 is a critical regulator of viral myocarditis and organ inflammation - Journal of Biomedical Science
Background Infections by viruses including severe acute respiratory syndrome coronavirus 2 could cause organ inflammations such as myocarditis, pneumonia and encephalitis. Innate immunity to viral nuc...
jbiomedsci.biomedcentral.com
December 18, 2024 at 1:41 AM
Happy to share that we identified TRIM18 as a critical regulator of viral myocarditis and organ inflammation in Journal of Biomedical Science
@natureportfolio.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
@natureportfolio.bsky.social
jbiomedsci.biomedcentral.com/articles/10....
Excited to share that our study about how EphA2 phosphorylates NLRP3 to inhibit NLRP3 inflammasome activation in AECs is published and covered in EMBO Reports It is also highlighted in News & Views
@emboreports.bsky.social
www.embopress.org/doi/full/10....
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@emboreports.bsky.social
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EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells | EMBO reports
image image The tyrosine kinase receptor EphA2 functions as a negative regulator of inflammasome
activation upon reovirus infection by targeting NLRP3 in airway epithelia. EphA2 also suppresses infla...
www.embopress.org
December 18, 2024 at 1:35 AM
Excited to share that our study about how EphA2 phosphorylates NLRP3 to inhibit NLRP3 inflammasome activation in AECs is published and covered in EMBO Reports It is also highlighted in News & Views
@emboreports.bsky.social
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
@emboreports.bsky.social
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Thrilled to share that our study about how TRIM29 regulates NLRP6 and NLRP9b inflammasomes to control viral enteritis is published in Mucosal Immunology @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
www.sciencedirect.com/science/arti...
www.mucosalimmunology.org/article/S193...
www.sciencedirect.com/science/arti...
www.mucosalimmunology.org/article/S193...
TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways
Infections by enteric virus and intestinal inflammation are recognized as a leading cause of deadly gastroenteritis, and NLRP6 and NLRP9b signaling co…
www.sciencedirect.com
December 18, 2024 at 1:25 AM
Thrilled to share that our study about how TRIM29 regulates NLRP6 and NLRP9b inflammasomes to control viral enteritis is published in Mucosal Immunology @mucosalimmunol.bsky.social @societymucosalimm.bsky.social
www.sciencedirect.com/science/arti...
www.mucosalimmunology.org/article/S193...
www.sciencedirect.com/science/arti...
www.mucosalimmunology.org/article/S193...
Thrilled to share that our study about how DHX15 employs NLRP6 inflammasome to control enteric RNA virus-indued enteritis in Cell Reports @cellpress.bsky.social www.cell.com/cell-reports...
DHX15 is required to control RNA virus-induced intestinal inflammation
Xing et al. show that DHX15 functions as an RNA virus sensor to produce IFN-β, IFN-λ3, and IL-18 in IECs and is required to control RNA virus-induced intestinal inflammation in vivo. They further demonstrate that DHX15 interacts with NLRP6 to trigger NLRP6 inflammasome activation for IL-18 secretion in IECs.
www.cell.com
December 17, 2024 at 1:47 AM
Thrilled to share that our study about how DHX15 employs NLRP6 inflammasome to control enteric RNA virus-indued enteritis in Cell Reports @cellpress.bsky.social www.cell.com/cell-reports...
Thrilled to share our collaboration study about how human Semaphorin-4A binds to ILT-4 receptor to drive Th2 immune responses in Nature Communications @natureportfolio.bsky.social rdcu.be/d3NI8
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4
Nature Communications - Semaphorin-4A is a cell surface protein with known functions in neural development and immune regulation, but the mechanism for immune modulation is unclear. Here the...
rdcu.be
December 17, 2024 at 1:36 AM
Thrilled to share our collaboration study about how human Semaphorin-4A binds to ILT-4 receptor to drive Th2 immune responses in Nature Communications @natureportfolio.bsky.social rdcu.be/d3NI8
www.nature.com/articles/s41...
www.nature.com/articles/s41...