Julia Meltzer
@juliameltzer.bsky.social
Burns and Ferrari Lab UNSW
Love the microbial dark matter 🖤🦠
Love the microbial dark matter 🖤🦠
Pinned
Julia Meltzer
@juliameltzer.bsky.social
· Jul 23
Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
An Asgard archaeon from a modern analog of ancient microbial mats
It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...
www.biorxiv.org
So excited to finally show the world a project years in the making. A huge group effort with lots of expertise leading to a unique #Asgard syntrophy story. Very fortunate to have been involved in cultivating and analysing this wonderful organism ❤️
Reposted by Julia Meltzer
🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
October 31, 2025 at 8:54 PM
🧶🧬 We present LMi4Boltz:
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
www.biorxiv.org/content/10.1...
Boltz-2 is an excellent open source alternative to AlphaFold3. However, high VRAM use restricts modeling large complexes. Using careful memory management, we increase the Boltz-2 size limit by >60% while maintaining execution speed.
Reposted by Julia Meltzer
This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬
LMI4Boltz: Optimizing VRAM utilization to predict large macromolecular complexes with consumer grade hardware
AlphaFold2 has revolutionized structural biology by enabling the prediction of protein structures approaching experimental quality. AlphaFold3 extends this framework to support modelling broad biomole...
www.biorxiv.org
October 31, 2025 at 9:40 PM
This is amazing work lead by Tom (@tlitfin.bsky.social) in my team. Always trying to get more for less and making computing efficient. So satisfying making science resources go further. Boltz2 is great for protein structure prediction and hopefully LMI4Boltz extends its use. Code on GitHub… 🧶🧬
Reposted by Julia Meltzer
This was fun! Folding whole proteomes… looking at tomogram, looking at genomes🤩 lots to discover!🧬🧶
An Asgard archaeon from a modern analog of ancient microbial mats
It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...
www.biorxiv.org
July 23, 2025 at 7:11 AM
This was fun! Folding whole proteomes… looking at tomogram, looking at genomes🤩 lots to discover!🧬🧶
So excited to finally show the world a project years in the making. A huge group effort with lots of expertise leading to a unique #Asgard syntrophy story. Very fortunate to have been involved in cultivating and analysing this wonderful organism ❤️
Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
An Asgard archaeon from a modern analog of ancient microbial mats
It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...
www.biorxiv.org
July 23, 2025 at 10:33 AM
So excited to finally show the world a project years in the making. A huge group effort with lots of expertise leading to a unique #Asgard syntrophy story. Very fortunate to have been involved in cultivating and analysing this wonderful organism ❤️
Reposted by Julia Meltzer
Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
An Asgard archaeon from a modern analog of ancient microbial mats
It has been proposed that eukaryotic cells evolved via symbiosis between sulfate-reducing bacteria and hydrogen-producing archaea. Here we describe a highly enriched culture of a novel Asgard archaeon...
www.biorxiv.org
July 23, 2025 at 8:48 AM
Our new preprint with a new #Asgard from stromatolites (and its Desulfobacterota companion). Complete circularised genomes of both, cool #cryoem images, protein modelling, etc
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Big group effort with a lot of people involved
#archaeasky #archaea
www.biorxiv.org/content/10.1...
Reposted by Julia Meltzer
Our Big Fantastic Virus Database (BFVD) is now published NAR! It contains protein structure predictions of major viral clades, enhanced by petabase-scale homology search and it's explorable on the web.
🌐 bfvd.foldseek.com
💾 bfvd.steineggerlab.workers.dev
📄 academic.oup.com/nar/advance-...
🌐 bfvd.foldseek.com
💾 bfvd.steineggerlab.workers.dev
📄 academic.oup.com/nar/advance-...
November 23, 2024 at 9:12 PM
Our Big Fantastic Virus Database (BFVD) is now published NAR! It contains protein structure predictions of major viral clades, enhanced by petabase-scale homology search and it's explorable on the web.
🌐 bfvd.foldseek.com
💾 bfvd.steineggerlab.workers.dev
📄 academic.oup.com/nar/advance-...
🌐 bfvd.foldseek.com
💾 bfvd.steineggerlab.workers.dev
📄 academic.oup.com/nar/advance-...
Go @hannjbrown.bsky.social and @iduggin.bsky.social !! Archaea champs 💪🏽
🚨 New paper alert! 🚨
MinD is famously known for positioning FtsZ at mid-cell in bacteria
In our study, myself and @iduggin.bsky.social found that MinD homologues in Haloferax volcanii influence the localisation of CetZ1, a homologue of FtsZ and tubulin
#Archaeasky #Microsky
MinD is famously known for positioning FtsZ at mid-cell in bacteria
In our study, myself and @iduggin.bsky.social found that MinD homologues in Haloferax volcanii influence the localisation of CetZ1, a homologue of FtsZ and tubulin
#Archaeasky #Microsky
Frontiers | MinD proteins regulate CetZ1 localization in Haloferax volcanii
url.au.m.mimecastprotect.com
November 23, 2024 at 11:07 PM
Go @hannjbrown.bsky.social and @iduggin.bsky.social !! Archaea champs 💪🏽
Sharing new tools made by Artyom Egorov in my group!
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...
1) loVis4u sensitively compares & visualises #phage or #plasmid seqs with beautiful vector graphics www.biorxiv.org/content/10.1...
2) iLund4u finds diversity hotspots/islands encoding eg virulence/ defence systems www.biorxiv.org/content/10.1...
November 23, 2024 at 1:52 AM
Reposted by Julia Meltzer
Now out in NSMB for those who missed our biorxiv back in 2023.. bacterial ESCRT-III-like #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😵💫 wonderful collaboration with Adai Colom’s lab and @rouxlab.bsky.social
rdcu.be/dZSPQ
rdcu.be/dZSPQ
November 21, 2024 at 5:59 AM
Reposted by Julia Meltzer
ArchaeaCast
Science Podcast · 3 Episodes · Updated Biweekly
podcasts.apple.com
November 15, 2024 at 4:57 PM
Join us at the JAMS Sydney community! 🫶🏻♥️
JAMS Sydney has made its way to Bluesky! ✨
Help us connect JAMSters as they make their way over so let us know if you'd like to be added! 🦠
go.bsky.app/B1uUprK
Help us connect JAMSters as they make their way over so let us know if you'd like to be added! 🦠
go.bsky.app/B1uUprK
November 20, 2024 at 7:49 AM
Join us at the JAMS Sydney community! 🫶🏻♥️
Reposted by Julia Meltzer
Finally started migrating from X to bsky and hoping to connect with more people interested in #Bioinformatics 🧬💻. Thanks @amanzanom.bsky.social for all the tips so far and if someone out there have any good tips, please let me know!
November 7, 2023 at 11:48 PM
Finally started migrating from X to bsky and hoping to connect with more people interested in #Bioinformatics 🧬💻. Thanks @amanzanom.bsky.social for all the tips so far and if someone out there have any good tips, please let me know!
Reposted by Julia Meltzer
A nice paper on microbial dark matter revealing that in situ devices increase coral's microbes culturability up to 570% is out on iScience 🧪. This device, initially used in soils, has proved to be useful in marine sponges and, now, in corals as well.
www.sciencedirect.com/science/arti...
#SymbioSky
www.sciencedirect.com/science/arti...
#SymbioSky
November 14, 2023 at 10:01 PM
A nice paper on microbial dark matter revealing that in situ devices increase coral's microbes culturability up to 570% is out on iScience 🧪. This device, initially used in soils, has proved to be useful in marine sponges and, now, in corals as well.
www.sciencedirect.com/science/arti...
#SymbioSky
www.sciencedirect.com/science/arti...
#SymbioSky
Reposted by Julia Meltzer
Hello Blueskis. Here is a starter pack of General Microbiology. It's a small list currently. Please feel free to self-nominate and I will add you.
go.bsky.app/QgSQHJ9
go.bsky.app/QgSQHJ9
November 12, 2024 at 9:33 PM
Hello Blueskis. Here is a starter pack of General Microbiology. It's a small list currently. Please feel free to self-nominate and I will add you.
go.bsky.app/QgSQHJ9
go.bsky.app/QgSQHJ9
Reposted by Julia Meltzer
I made a quick Starter Pack for scientists working on virus discovery - please reply if you’d like me to add you to the pack (or remove you) or to recommend anyone! #scisky go.bsky.app/HK1wxRb
November 16, 2024 at 4:44 PM
I made a quick Starter Pack for scientists working on virus discovery - please reply if you’d like me to add you to the pack (or remove you) or to recommend anyone! #scisky go.bsky.app/HK1wxRb
Reposted by Julia Meltzer
I made a starter pack for researchers who study various aspects of viral sociality. It's woefully incomplete and has lots of room to grow, so do message me if I've missed you!
go.bsky.app/3PfgjkP
#SocialViruses 🦠 🧪
go.bsky.app/3PfgjkP
#SocialViruses 🦠 🧪
November 17, 2024 at 2:40 PM
I made a starter pack for researchers who study various aspects of viral sociality. It's woefully incomplete and has lots of room to grow, so do message me if I've missed you!
go.bsky.app/3PfgjkP
#SocialViruses 🦠 🧪
go.bsky.app/3PfgjkP
#SocialViruses 🦠 🧪
Reposted by Julia Meltzer
added to Virology and Virus-Host interaction #2 go.bsky.app/6bSDmrW
November 18, 2024 at 11:51 AM
added to Virology and Virus-Host interaction #2 go.bsky.app/6bSDmrW