Jeff Henderson
@jphendersonmdphd.bsky.social
Professor at Washington University Medical School in St Louis, USA. Human-microbe interactions in health and disease with a focus on exometabolites and metal ion interactions. Infectious diseases physician-scientist.
Worth reading and considering carefully for those of us in academia. Well stated @holdenthorp.bsky.social!
May 10, 2025 at 1:34 PM
Worth reading and considering carefully for those of us in academia. Well stated @holdenthorp.bsky.social!
Reposted by Jeff Henderson
"Do you support reducing federal funding for medical research?"
21% support, 77% OPPOSE
www.washingtonpost.com/politics/202...
21% support, 77% OPPOSE
www.washingtonpost.com/politics/202...
Trump approval sinks as Americans criticize his major policies, poll finds
President Donald Trump’s 100 days poll finds a lower approval rating, growing opposition to his agenda and opposition to many of his major initiatives.
www.washingtonpost.com
April 27, 2025 at 3:20 PM
"Do you support reducing federal funding for medical research?"
21% support, 77% OPPOSE
www.washingtonpost.com/politics/202...
21% support, 77% OPPOSE
www.washingtonpost.com/politics/202...
I am grateful and excited to begin this new work!
It is tough to evaluate and fund risky, interdisciplinary work but the visionaries at the Hypothesis Fund were willing to help! Many thanks to brilliant #HFScouts Dianne Newman for very thoughtful engagement.
It is tough to evaluate and fund risky, interdisciplinary work but the visionaries at the Hypothesis Fund were willing to help! Many thanks to brilliant #HFScouts Dianne Newman for very thoughtful engagement.
🎊Announcing our first awardees of 2025! These talented scientists are generating new knowledge about host immunity, bacterial pathogens, and gene-environment interactions. Read more about them: bit.ly/HFAwardees.
Hear from our #HFScouts below!🧵/1
Hear from our #HFScouts below!🧵/1
February 4, 2025 at 6:11 PM
I am grateful and excited to begin this new work!
It is tough to evaluate and fund risky, interdisciplinary work but the visionaries at the Hypothesis Fund were willing to help! Many thanks to brilliant #HFScouts Dianne Newman for very thoughtful engagement.
It is tough to evaluate and fund risky, interdisciplinary work but the visionaries at the Hypothesis Fund were willing to help! Many thanks to brilliant #HFScouts Dianne Newman for very thoughtful engagement.
Who is in danger?
NEW FROM THE LAB: For respiratory virus infections, antivirals must generally be administered before progression to severe illness to be effective. As COVID arrived, we sought a metabolomic signature in patients to predict this. We found one!
journals.asm.org/doi/full/10....
NEW FROM THE LAB: For respiratory virus infections, antivirals must generally be administered before progression to severe illness to be effective. As COVID arrived, we sought a metabolomic signature in patients to predict this. We found one!
journals.asm.org/doi/full/10....
Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival | mBio
In a new respiratory virus pandemic, the ability to identify patients at greatest risk for severe disease is essential to direct scarce medical resources to those most likely to benefit from them. Tools to predict disease severity are best developed early ...
journals.asm.org
November 26, 2024 at 2:58 PM
Who is in danger?
NEW FROM THE LAB: For respiratory virus infections, antivirals must generally be administered before progression to severe illness to be effective. As COVID arrived, we sought a metabolomic signature in patients to predict this. We found one!
journals.asm.org/doi/full/10....
NEW FROM THE LAB: For respiratory virus infections, antivirals must generally be administered before progression to severe illness to be effective. As COVID arrived, we sought a metabolomic signature in patients to predict this. We found one!
journals.asm.org/doi/full/10....
Reposted by Jeff Henderson
"Science is a messy human process that converges on the truth...If everyone doing science has the same background, those biases are amplified. But if groups of scientists bring different backgrounds to their work, they’ll have different biases and will converge on the truth faster."
May 5, 2024 at 8:00 PM
"Science is a messy human process that converges on the truth...If everyone doing science has the same background, those biases are amplified. But if groups of scientists bring different backgrounds to their work, they’ll have different biases and will converge on the truth faster."
Talented student Jim Heffernan followed the data on an unexpected result in lab to this surprising resolution: a siderophore system associated with increased pathogenic potential in Enterobacterales is also a (previously unappreciated) quorum sensing system!
Yersiniabactin is a quorum-sensing autoinducer and siderophore in uropathogenic Escherichia coli
mBio journal from JP Henderson
journals.asm.org/doi/10.1128/...
mBio journal from JP Henderson
journals.asm.org/doi/10.1128/...
January 24, 2024 at 4:33 AM
Talented student Jim Heffernan followed the data on an unexpected result in lab to this surprising resolution: a siderophore system associated with increased pathogenic potential in Enterobacterales is also a (previously unappreciated) quorum sensing system!
New from the lab: E.coli don’t just release the siderophore Enterobactin (Ent), they release Ent fragments. Why? After recovering iron from iron-Ent after minimal hydrolysis, E.coli send the pieces back out for bonus rounds of iron-scavenging. Reduce, re-use, recycle! www.jbc.org/article/S002...
December 14, 2023 at 5:06 AM
New from the lab: E.coli don’t just release the siderophore Enterobactin (Ent), they release Ent fragments. Why? After recovering iron from iron-Ent after minimal hydrolysis, E.coli send the pieces back out for bonus rounds of iron-scavenging. Reduce, re-use, recycle! www.jbc.org/article/S002...