Jotbody-Beyond Affinity-
@jotbody.bsky.social
Empowering Science with Precision
Biotechnology Research• Hong Kong
Biotechnology Research• Hong Kong
💪 Small in size, strong in performance
Anti-PD-L1 VHH Antibody (JOT0002-5) by Jotbody: precise PD-L1 detection (ELISA/WB/IHC/IF/FC), 14.4 kDa, KD=0.363 nM. Ideal for research & diagnostics.
#PDL1 #VHH #nanobody #lifescience #biotech #researchtools
Anti-PD-L1 VHH Antibody (JOT0002-5) by Jotbody: precise PD-L1 detection (ELISA/WB/IHC/IF/FC), 14.4 kDa, KD=0.363 nM. Ideal for research & diagnostics.
#PDL1 #VHH #nanobody #lifescience #biotech #researchtools
November 6, 2025 at 7:48 AM
💪 Small in size, strong in performance
Anti-PD-L1 VHH Antibody (JOT0002-5) by Jotbody: precise PD-L1 detection (ELISA/WB/IHC/IF/FC), 14.4 kDa, KD=0.363 nM. Ideal for research & diagnostics.
#PDL1 #VHH #nanobody #lifescience #biotech #researchtools
Anti-PD-L1 VHH Antibody (JOT0002-5) by Jotbody: precise PD-L1 detection (ELISA/WB/IHC/IF/FC), 14.4 kDa, KD=0.363 nM. Ideal for research & diagnostics.
#PDL1 #VHH #nanobody #lifescience #biotech #researchtools
When nanobodies are immobilized directionally via SpyTag/SpyCatcher (90% coupling efficiency), binding capacity triples—and achieves >95% purity from serum with outstanding reuse.
jotbody.com/could-proper...
jotbody.com/could-proper...
August 21, 2025 at 3:00 AM
When nanobodies are immobilized directionally via SpyTag/SpyCatcher (90% coupling efficiency), binding capacity triples—and achieves >95% purity from serum with outstanding reuse.
jotbody.com/could-proper...
jotbody.com/could-proper...
Plasma EV tau isoform ratios (3R/4R) and TDP-43 levels can distinguish FTD, ALS & PSP with over 90% accuracy—a promising step toward a non-invasive liquid biopsy. #EVs #Neurodegeneration
🔗 Read more about their research: jotbody.com/what-if-extr...
🔗 Read more about their research: jotbody.com/what-if-extr...
August 19, 2025 at 2:42 AM
Plasma EV tau isoform ratios (3R/4R) and TDP-43 levels can distinguish FTD, ALS & PSP with over 90% accuracy—a promising step toward a non-invasive liquid biopsy. #EVs #Neurodegeneration
🔗 Read more about their research: jotbody.com/what-if-extr...
🔗 Read more about their research: jotbody.com/what-if-extr...
🔍 Can nanobodies transform industrial protein purification?
NbHB1 resin hit 96% purity, 81% recovery, stayed stable for 25 cycles, & leaked <1.7 ng/mL ligand.
A leap forward for scalable rHBsAg-VLP production.
Read more: jotbody.com/can-nanobodi...
NbHB1 resin hit 96% purity, 81% recovery, stayed stable for 25 cycles, & leaked <1.7 ng/mL ligand.
A leap forward for scalable rHBsAg-VLP production.
Read more: jotbody.com/can-nanobodi...
August 12, 2025 at 9:30 AM
🔍 Can nanobodies transform industrial protein purification?
NbHB1 resin hit 96% purity, 81% recovery, stayed stable for 25 cycles, & leaked <1.7 ng/mL ligand.
A leap forward for scalable rHBsAg-VLP production.
Read more: jotbody.com/can-nanobodi...
NbHB1 resin hit 96% purity, 81% recovery, stayed stable for 25 cycles, & leaked <1.7 ng/mL ligand.
A leap forward for scalable rHBsAg-VLP production.
Read more: jotbody.com/can-nanobodi...
❓ What if CRISPR could be delivered safely to brain cells without virus? A new EV platform shows >40% hippocampal editing in vivo—game changer.
📖 Read more: jotbody.com/are-evs-the-...
📖 Read more: jotbody.com/are-evs-the-...
August 5, 2025 at 2:30 AM
❓ What if CRISPR could be delivered safely to brain cells without virus? A new EV platform shows >40% hippocampal editing in vivo—game changer.
📖 Read more: jotbody.com/are-evs-the-...
📖 Read more: jotbody.com/are-evs-the-...
VS2 nanobody resin binds 16.23 mg/mL of SUMO fusion protein, works across eight targets, and retains >80% capacity after 25 NaOH cleans. Efficient purification, redefined.
🔗 jotbody.com/can-nanobody...
🔗 jotbody.com/can-nanobody...
July 30, 2025 at 2:19 AM
VS2 nanobody resin binds 16.23 mg/mL of SUMO fusion protein, works across eight targets, and retains >80% capacity after 25 NaOH cleans. Efficient purification, redefined.
🔗 jotbody.com/can-nanobody...
🔗 jotbody.com/can-nanobody...
Can dopamine coated EVs target dopamine neurons and stop Parkinson’s damage?
🔬 Dopa EVs show targeted uptake, rescue dopaminergic neurons, and trigger protective autophagy in mouse PD models.
jotbody.com/can-dopamine...
🔬 Dopa EVs show targeted uptake, rescue dopaminergic neurons, and trigger protective autophagy in mouse PD models.
jotbody.com/can-dopamine...
July 29, 2025 at 2:58 AM
Can dopamine coated EVs target dopamine neurons and stop Parkinson’s damage?
🔬 Dopa EVs show targeted uptake, rescue dopaminergic neurons, and trigger protective autophagy in mouse PD models.
jotbody.com/can-dopamine...
🔬 Dopa EVs show targeted uptake, rescue dopaminergic neurons, and trigger protective autophagy in mouse PD models.
jotbody.com/can-dopamine...
Could EVs carry RNA therapies—safely & efficiently without viruses?
✅ EVs deliver miRNA, mRNA, and CRISPR guides across the BBB & tumors with low immune risk.
Read more about the review: jotbody.com/could-extrac...
✅ EVs deliver miRNA, mRNA, and CRISPR guides across the BBB & tumors with low immune risk.
Read more about the review: jotbody.com/could-extrac...
July 23, 2025 at 2:34 AM
Could EVs carry RNA therapies—safely & efficiently without viruses?
✅ EVs deliver miRNA, mRNA, and CRISPR guides across the BBB & tumors with low immune risk.
Read more about the review: jotbody.com/could-extrac...
✅ EVs deliver miRNA, mRNA, and CRISPR guides across the BBB & tumors with low immune risk.
Read more about the review: jotbody.com/could-extrac...
🚀 Nanobody + quantum microspheres detect aflatoxin B₁ at 0.03 ng/mL in just 8 min—10× more sensitive than gold strips! Precision food safety, no lab needed.
🔗 jotbody.com/is-your-food...
🔗 jotbody.com/is-your-food...
Is Your Food Safety Test Sensitive Enough? - Jotbody
Aflatoxin B₁ (AFB₁), a potent carcinogenic mycotoxin, frequently contaminates staples like corn and peanuts worldwide. Traditional rapid immunochromatographic strips (ICTS) often fail to detect trace ...
jotbody.com
July 22, 2025 at 2:54 AM
🚀 Nanobody + quantum microspheres detect aflatoxin B₁ at 0.03 ng/mL in just 8 min—10× more sensitive than gold strips! Precision food safety, no lab needed.
🔗 jotbody.com/is-your-food...
🔗 jotbody.com/is-your-food...
🧬Nanobody-based AuNP cluster LFIA rapidly detects survivin in urine—LOD just 3.90 ng/mL. Fast, stable & precise bladder cancer diagnosis in minutes, no labs needed!
🔗https://jotbody.com/can-nanobody-strips-outsmart-invasive-bladder-cancer-tests/
#Nanobody #IVD #BladderCancer #Diagnostics #RapidTest
🔗https://jotbody.com/can-nanobody-strips-outsmart-invasive-bladder-cancer-tests/
#Nanobody #IVD #BladderCancer #Diagnostics #RapidTest
July 16, 2025 at 6:12 AM
🧬Nanobody-based AuNP cluster LFIA rapidly detects survivin in urine—LOD just 3.90 ng/mL. Fast, stable & precise bladder cancer diagnosis in minutes, no labs needed!
🔗https://jotbody.com/can-nanobody-strips-outsmart-invasive-bladder-cancer-tests/
#Nanobody #IVD #BladderCancer #Diagnostics #RapidTest
🔗https://jotbody.com/can-nanobody-strips-outsmart-invasive-bladder-cancer-tests/
#Nanobody #IVD #BladderCancer #Diagnostics #RapidTest
🔬 Nanobody rapid test detects NMP22 & survivin for bladder cancer:
• 100% sensitivity, 90.9% specificity (dual marker strip)
• Visual results in minutes
📖 Read:https://jotbody.com/can-a-nanobody-urine-strip-outperform-invasive-bladder-cancer-screening/
• 100% sensitivity, 90.9% specificity (dual marker strip)
• Visual results in minutes
📖 Read:https://jotbody.com/can-a-nanobody-urine-strip-outperform-invasive-bladder-cancer-screening/
July 9, 2025 at 3:47 AM
🔬 Nanobody rapid test detects NMP22 & survivin for bladder cancer:
• 100% sensitivity, 90.9% specificity (dual marker strip)
• Visual results in minutes
📖 Read:https://jotbody.com/can-a-nanobody-urine-strip-outperform-invasive-bladder-cancer-screening/
• 100% sensitivity, 90.9% specificity (dual marker strip)
• Visual results in minutes
📖 Read:https://jotbody.com/can-a-nanobody-urine-strip-outperform-invasive-bladder-cancer-screening/
🧬 Modular EV targeting breakthrough: Fc EVs (antibody decorated) show 339 times cancer cell uptake & 180 times tumor accumulation, delivering doxorubicin effectively in mice.
A new era for precision EV therapies. 🔗 jotbody.com/can-antibody...
#ExtracellularVesicles #CancerTherapy
A new era for precision EV therapies. 🔗 jotbody.com/can-antibody...
#ExtracellularVesicles #CancerTherapy
Can Antibody Decorated EVs Deliver Drugs with 180 Times Tumor Targeting Efficiency? - Jotbody
Explore Nature Biomedical Engineering’s 2025 breakthrough: antibody binding EVs for precise cancer therapy—up to 180 times tumor targeting and improved efficacy in vivo.
jotbody.com
July 8, 2025 at 2:54 AM
🧬 Modular EV targeting breakthrough: Fc EVs (antibody decorated) show 339 times cancer cell uptake & 180 times tumor accumulation, delivering doxorubicin effectively in mice.
A new era for precision EV therapies. 🔗 jotbody.com/can-antibody...
#ExtracellularVesicles #CancerTherapy
A new era for precision EV therapies. 🔗 jotbody.com/can-antibody...
#ExtracellularVesicles #CancerTherapy
✨ Nanobody Breakthrough in Zika Detection! 🦠
Nanobody test detects 1 ng/mL Zika NS1, results in 15 minutes ⏱️, no Dengue cross-reaction. Affordable, portable, and stable for 28 days 🌡️—ideal for self-testing.
🔗 jotbody.com/could-a-smal...
#Nanobody #IVD #Diagnostics #Zika
Nanobody test detects 1 ng/mL Zika NS1, results in 15 minutes ⏱️, no Dengue cross-reaction. Affordable, portable, and stable for 28 days 🌡️—ideal for self-testing.
🔗 jotbody.com/could-a-smal...
#Nanobody #IVD #Diagnostics #Zika
July 3, 2025 at 6:18 AM
✨ Nanobody Breakthrough in Zika Detection! 🦠
Nanobody test detects 1 ng/mL Zika NS1, results in 15 minutes ⏱️, no Dengue cross-reaction. Affordable, portable, and stable for 28 days 🌡️—ideal for self-testing.
🔗 jotbody.com/could-a-smal...
#Nanobody #IVD #Diagnostics #Zika
Nanobody test detects 1 ng/mL Zika NS1, results in 15 minutes ⏱️, no Dengue cross-reaction. Affordable, portable, and stable for 28 days 🌡️—ideal for self-testing.
🔗 jotbody.com/could-a-smal...
#Nanobody #IVD #Diagnostics #Zika
🧬 Hybrid EVs hit ≈40% loading efficiency for siRNA/plasmids using a 30-min pH-triggered fusion with LCNPs—double the performance of passive methods.
Surface proteins and function intact.
🔗 jotbody.com/why-loading-...
#EVResearch #GeneDelivery
Surface proteins and function intact.
🔗 jotbody.com/why-loading-...
#EVResearch #GeneDelivery
July 2, 2025 at 6:14 AM
🧬 Hybrid EVs hit ≈40% loading efficiency for siRNA/plasmids using a 30-min pH-triggered fusion with LCNPs—double the performance of passive methods.
Surface proteins and function intact.
🔗 jotbody.com/why-loading-...
#EVResearch #GeneDelivery
Surface proteins and function intact.
🔗 jotbody.com/why-loading-...
#EVResearch #GeneDelivery
🎯 Nanobody raises extracellular pH by ~0.11 units
🚫 Blocks invasion (Ki ≈ 15.6 nM)
🌬 Lung metastasis drops 50% → 13% in mice (~74% reduction)
✅ No tumor shrinkage or toxicity
Oncotarget study 👇
jotbody.com/could-one-ti...
🚫 Blocks invasion (Ki ≈ 15.6 nM)
🌬 Lung metastasis drops 50% → 13% in mice (~74% reduction)
✅ No tumor shrinkage or toxicity
Oncotarget study 👇
jotbody.com/could-one-ti...
June 24, 2025 at 7:25 AM
🎯 Nanobody raises extracellular pH by ~0.11 units
🚫 Blocks invasion (Ki ≈ 15.6 nM)
🌬 Lung metastasis drops 50% → 13% in mice (~74% reduction)
✅ No tumor shrinkage or toxicity
Oncotarget study 👇
jotbody.com/could-one-ti...
🚫 Blocks invasion (Ki ≈ 15.6 nM)
🌬 Lung metastasis drops 50% → 13% in mice (~74% reduction)
✅ No tumor shrinkage or toxicity
Oncotarget study 👇
jotbody.com/could-one-ti...
🚨 Storing EVs in plain PBS? You might be losing 50–90% of your sample—even at –80 °C.
💡 Add albumin + trehalose, and get 75–95% recovery—even after 26 weeks.
Don’t let your buffer cost you results!
🔗 jotbody.com/is-your-ev-s...
💡 Add albumin + trehalose, and get 75–95% recovery—even after 26 weeks.
Don’t let your buffer cost you results!
🔗 jotbody.com/is-your-ev-s...
Is Your EV Storage Buffer causing the loss of Up to 90% of Your Sample? - Jotbody
Learn how storing extracellular vehicles (EVs) in PBS can result in up to 90% loss—even at −80 °C—and why buffers enriched with albumin and trehalose enable 75–95% recovery, preserving EV quantity and...
jotbody.com
June 24, 2025 at 2:54 AM
🚨 Storing EVs in plain PBS? You might be losing 50–90% of your sample—even at –80 °C.
💡 Add albumin + trehalose, and get 75–95% recovery—even after 26 weeks.
Don’t let your buffer cost you results!
🔗 jotbody.com/is-your-ev-s...
💡 Add albumin + trehalose, and get 75–95% recovery—even after 26 weeks.
Don’t let your buffer cost you results!
🔗 jotbody.com/is-your-ev-s...
🧊 Lyophilizing EVs without protection kills ~40% of vesicles and degrades miRNAs.
🧪 Adding trehalose or mannitol preserves structure, cargo, and enzyme activity—even at room temp.
📦 Room-temp EV storage = cost savings + broader access.
🔗 Read the full study: jotbody.com/whats-the-re...
🧪 Adding trehalose or mannitol preserves structure, cargo, and enzyme activity—even at room temp.
📦 Room-temp EV storage = cost savings + broader access.
🔗 Read the full study: jotbody.com/whats-the-re...
What’s the recommended approach for lyophilizing EVs to guarantee recovery and performance? - Jotbody
Discover how the right lyophilization buffer, especially with protectants like trehalose or mannitol, is key to preserving the stability, activity, and therapeutic potential of extracellular vesicles ...
jotbody.com
June 17, 2025 at 2:23 AM
🧊 Lyophilizing EVs without protection kills ~40% of vesicles and degrades miRNAs.
🧪 Adding trehalose or mannitol preserves structure, cargo, and enzyme activity—even at room temp.
📦 Room-temp EV storage = cost savings + broader access.
🔗 Read the full study: jotbody.com/whats-the-re...
🧪 Adding trehalose or mannitol preserves structure, cargo, and enzyme activity—even at room temp.
📦 Room-temp EV storage = cost savings + broader access.
🔗 Read the full study: jotbody.com/whats-the-re...
🔬 How strong is your EV lysis buffer?
Mild buffer gently extracts surface markers like CD55/CD59.
Moderate buffer boosts tetraspanins (CD9/CD81/CD63).
Need deep cargo? Harsher lysis works—but requires cleanup.
Which are you using? 🤔
jotbody.com/choose-wisel...
Mild buffer gently extracts surface markers like CD55/CD59.
Moderate buffer boosts tetraspanins (CD9/CD81/CD63).
Need deep cargo? Harsher lysis works—but requires cleanup.
Which are you using? 🤔
jotbody.com/choose-wisel...
Choose Wisely to Unlock Biomarkers - Jotbody
Learn how different lysis buffers affect extracellular vesicle analysis—what works, what doesn’t, and why it matters, based on a 2024 guidance.
jotbody.com
June 10, 2025 at 2:31 AM
🔬 How strong is your EV lysis buffer?
Mild buffer gently extracts surface markers like CD55/CD59.
Moderate buffer boosts tetraspanins (CD9/CD81/CD63).
Need deep cargo? Harsher lysis works—but requires cleanup.
Which are you using? 🤔
jotbody.com/choose-wisel...
Mild buffer gently extracts surface markers like CD55/CD59.
Moderate buffer boosts tetraspanins (CD9/CD81/CD63).
Need deep cargo? Harsher lysis works—but requires cleanup.
Which are you using? 🤔
jotbody.com/choose-wisel...
Nanobodies are revolutionizing cancer therapy by targeting the tumor microenvironment for precise drug delivery, including:
Glioblastoma Invasion Inhibition
Enhanced Imaging in Gastric Cancer
Targeted Photodynamic Therapy
Discover the latest research: jotbody.com/nanobodies-p...
Glioblastoma Invasion Inhibition
Enhanced Imaging in Gastric Cancer
Targeted Photodynamic Therapy
Discover the latest research: jotbody.com/nanobodies-p...
June 3, 2025 at 9:21 AM
Nanobodies are revolutionizing cancer therapy by targeting the tumor microenvironment for precise drug delivery, including:
Glioblastoma Invasion Inhibition
Enhanced Imaging in Gastric Cancer
Targeted Photodynamic Therapy
Discover the latest research: jotbody.com/nanobodies-p...
Glioblastoma Invasion Inhibition
Enhanced Imaging in Gastric Cancer
Targeted Photodynamic Therapy
Discover the latest research: jotbody.com/nanobodies-p...
Storing EVs in PBS leads to ~40% loss over 10 weeks.
PBS + 30% Glycerol: 22.7% reduction
PBS + 6% DMSO: 16.4% reduction
PBS + 25 mM Trehalose: Less than 10% reduction. Optimize your EV storage today!
jotbody.com/enhancing-ex...
PBS + 30% Glycerol: 22.7% reduction
PBS + 6% DMSO: 16.4% reduction
PBS + 25 mM Trehalose: Less than 10% reduction. Optimize your EV storage today!
jotbody.com/enhancing-ex...
Enhancing Extracellular Vesicle Preservation: The Role of Cryoprotectants - Jotbody
Discover how cryoprotectants like trehalose, glycerol, and DMSO significantly improve the stability of extracellular vesicles (EVs) during storage, based on recent research findings.
jotbody.com
June 3, 2025 at 2:32 AM
Storing EVs in PBS leads to ~40% loss over 10 weeks.
PBS + 30% Glycerol: 22.7% reduction
PBS + 6% DMSO: 16.4% reduction
PBS + 25 mM Trehalose: Less than 10% reduction. Optimize your EV storage today!
jotbody.com/enhancing-ex...
PBS + 30% Glycerol: 22.7% reduction
PBS + 6% DMSO: 16.4% reduction
PBS + 25 mM Trehalose: Less than 10% reduction. Optimize your EV storage today!
jotbody.com/enhancing-ex...
Milk-derived extracellular vesicles (mEVs) offer natural therapeutic benefits and can be engineered for targeted drug delivery, including oral administration.
Learn more: link.springer.com/article/10.1...
Learn more: link.springer.com/article/10.1...
May 27, 2025 at 2:03 AM
Milk-derived extracellular vesicles (mEVs) offer natural therapeutic benefits and can be engineered for targeted drug delivery, including oral administration.
Learn more: link.springer.com/article/10.1...
Learn more: link.springer.com/article/10.1...
Bovine milk-derived EVs combat K. pneumoniae-induced oxidative stress & ferroptosis in bMECs, offering a natural mastitis remedy.
Study: jotbody.com/bovine-milk-...
Study: jotbody.com/bovine-milk-...
Bovine milk-derived extracellular vesicles reduce oxidative stress and ferroptosis induced by Klebsiella pneumoniae in bovine mammary epithelial cells - Journal of Animal Science and Biotechnology
Background Ferroptosis is characterized by increased production of reactive oxygen species (ROS) and membrane lipid peroxidation that can exacerbate inflammatory damage. Extracellular vesicles (EVs) i...
jasbsci.biomedcentral.com
May 20, 2025 at 2:47 AM
Bovine milk-derived EVs combat K. pneumoniae-induced oxidative stress & ferroptosis in bMECs, offering a natural mastitis remedy.
Study: jotbody.com/bovine-milk-...
Study: jotbody.com/bovine-milk-...
Can humanized nanobodies match native performance?
Yes! A 2024 study shows CD19 CAR-Ts with humanized VHHs retained full cytotoxicity.
🔗 jotbody.com/can-humanize...
Yes! A 2024 study shows CD19 CAR-Ts with humanized VHHs retained full cytotoxicity.
🔗 jotbody.com/can-humanize...
May 13, 2025 at 10:01 AM
Can humanized nanobodies match native performance?
Yes! A 2024 study shows CD19 CAR-Ts with humanized VHHs retained full cytotoxicity.
🔗 jotbody.com/can-humanize...
Yes! A 2024 study shows CD19 CAR-Ts with humanized VHHs retained full cytotoxicity.
🔗 jotbody.com/can-humanize...
Plant nanoparticles from red cabbage cut gut inflammation by 50%! Engineered vesicles safely targeted and repaired colon damage orally. Future IBD treatment? 🌿
jotbody.com/plant-derive...
jotbody.com/plant-derive...
May 13, 2025 at 6:45 AM
Plant nanoparticles from red cabbage cut gut inflammation by 50%! Engineered vesicles safely targeted and repaired colon damage orally. Future IBD treatment? 🌿
jotbody.com/plant-derive...
jotbody.com/plant-derive...
Researchers engineered two nanobodies that bind to Ebola to neutralise viral particles in vitro.
🚀 The result:
• Animal Survival: 50% longer survival day.
• Viral Load Reduction: Up to 1,000-fold decrease.
Read more about the study: jotbody.com/event_catego...
🚀 The result:
• Animal Survival: 50% longer survival day.
• Viral Load Reduction: Up to 1,000-fold decrease.
Read more about the study: jotbody.com/event_catego...
May 6, 2025 at 4:13 PM
Researchers engineered two nanobodies that bind to Ebola to neutralise viral particles in vitro.
🚀 The result:
• Animal Survival: 50% longer survival day.
• Viral Load Reduction: Up to 1,000-fold decrease.
Read more about the study: jotbody.com/event_catego...
🚀 The result:
• Animal Survival: 50% longer survival day.
• Viral Load Reduction: Up to 1,000-fold decrease.
Read more about the study: jotbody.com/event_catego...