John Zupancic
@johnzupancic.bsky.social
Neonatologist @bidmcneo and @harvardmed
Babies | Health Services Research | Clinical Epidemiology
connects.catalyst.harvard.edu/Profiles/display/Person/3581
ORCID: https://orcid.org/0000-0003-1734-7193
he/him/his
posts = mine
Babies | Health Services Research | Clinical Epidemiology
connects.catalyst.harvard.edu/Profiles/display/Person/3581
ORCID: https://orcid.org/0000-0003-1734-7193
he/him/his
posts = mine
Pinned
John Zupancic
@johnzupancic.bsky.social
· Nov 16
As a welcome to our new BlueSky Friends, we just got a 30% discount code for the book below through Oxford University Press. Happy reading!
#NeoSky #NeoEBM
global.oup.com/academic/pro... and enter code AMPROMD9 at checkout
#NeoSky #NeoEBM
global.oup.com/academic/pro... and enter code AMPROMD9 at checkout
Lots more info (including state-specific relevant to your situation) at ccf.georgetown.edu and www.kff.org
May 8, 2025 at 4:44 PM
Lots more info (including state-specific relevant to your situation) at ccf.georgetown.edu and www.kff.org
3. That makes it one of our most important tools for ensuring equity (slide courtesy of Dr. Shah)
May 8, 2025 at 4:44 PM
3. That makes it one of our most important tools for ensuring equity (slide courtesy of Dr. Shah)
Dr. Shetal Shah (@nicubatman on Instagram and the Other place) Harvard BIDMC Newborn Epidemiology and HSR conference, reminding us that 1. Health insurance for all children is a civil right and 2. Medicaid is the single biggest payor for US births
May 8, 2025 at 4:44 PM
Dr. Shetal Shah (@nicubatman on Instagram and the Other place) Harvard BIDMC Newborn Epidemiology and HSR conference, reminding us that 1. Health insurance for all children is a civil right and 2. Medicaid is the single biggest payor for US births
Reposted by John Zupancic
COLLABORATE, coming 2025, will determine the effects of donor milk, formula, and cow-milk fortifier on surgical NEC, survival & cognition in extremely preterm babies, key questions parents & clinicians have been asking for many years. Explainer & summary here: www.imperial.ac.uk/neonatal-dat...
December 17, 2024 at 4:04 PM
COLLABORATE, coming 2025, will determine the effects of donor milk, formula, and cow-milk fortifier on surgical NEC, survival & cognition in extremely preterm babies, key questions parents & clinicians have been asking for many years. Explainer & summary here: www.imperial.ac.uk/neonatal-dat...
Reposted by John Zupancic
The National Neonatal Research Database is an amazing collaborative effort by all neonatal units in England, Scotland & Wales. Read our Christmas Newsletter here sway.cloud.microsoft/TRwgQx0jRac9... @99nicu.bsky.social @neonatalnursesuk.bsky.social @
Created using Microsoft Sway
COLLABORATE is an efficient, UK-wide, real-world-data-enabled, digital technology-facilitated, adaptive, group-sequential, 2-randomisation, controlled trial to determine clinical efficacy, effect size
sway.cloud.microsoft
December 19, 2024 at 2:45 PM
The National Neonatal Research Database is an amazing collaborative effort by all neonatal units in England, Scotland & Wales. Read our Christmas Newsletter here sway.cloud.microsoft/TRwgQx0jRac9... @99nicu.bsky.social @neonatalnursesuk.bsky.social @
Reposted by John Zupancic
Sharing new paper from our workshop in #PAS2023
Navigating Information Overload on Social Media: Opportunities & Misadventures for Clinicians and Professionals www.newbornjournal.org/abstractArti...
@briankingneo.bsky.social @souvikneo.bsky.social
#neosky @ebneo.bsky.social @espr-esn.bsky.social
Navigating Information Overload on Social Media: Opportunities & Misadventures for Clinicians and Professionals www.newbornjournal.org/abstractArti...
@briankingneo.bsky.social @souvikneo.bsky.social
#neosky @ebneo.bsky.social @espr-esn.bsky.social
December 21, 2024 at 11:38 PM
Sharing new paper from our workshop in #PAS2023
Navigating Information Overload on Social Media: Opportunities & Misadventures for Clinicians and Professionals www.newbornjournal.org/abstractArti...
@briankingneo.bsky.social @souvikneo.bsky.social
#neosky @ebneo.bsky.social @espr-esn.bsky.social
Navigating Information Overload on Social Media: Opportunities & Misadventures for Clinicians and Professionals www.newbornjournal.org/abstractArti...
@briankingneo.bsky.social @souvikneo.bsky.social
#neosky @ebneo.bsky.social @espr-esn.bsky.social
Bonus content: A fascinating interview about the paper with Drs. Philip Sunshine and William Northway
youtu.be/79prakcjBjc?...
6/6
youtu.be/79prakcjBjc?...
6/6
Birth of BPD: A Conversation with Dr. William Northway, Dr. Philip Sunshine & Dr. David Cornfield
YouTube video by Stanford Medicine Children's Health
youtu.be
December 21, 2024 at 6:03 PM
Bonus content: A fascinating interview about the paper with Drs. Philip Sunshine and William Northway
youtu.be/79prakcjBjc?...
6/6
youtu.be/79prakcjBjc?...
6/6
Case reports and series may be prone to bias, but in the hands of committed scientists, observation is still the entry point to improved outcome.
5/6
5/6
December 21, 2024 at 6:03 PM
Case reports and series may be prone to bias, but in the hands of committed scientists, observation is still the entry point to improved outcome.
5/6
5/6
…including progression of disease with path, clinical, radiological lenses; very early discussion of acquired pulmonary hypertension; role of oxygen; separation of two overlapping disease entities with eventual demonstration of distinct treatment modalities.
4/6
4/6
December 21, 2024 at 6:03 PM
…including progression of disease with path, clinical, radiological lenses; very early discussion of acquired pulmonary hypertension; role of oxygen; separation of two overlapping disease entities with eventual demonstration of distinct treatment modalities.
4/6
4/6
For your consideration:
Careful description, with no statistical comparisons, still brought a number of lasting truths to the table in this first comprehensive description of BPD…
3/6
Careful description, with no statistical comparisons, still brought a number of lasting truths to the table in this first comprehensive description of BPD…
3/6
December 21, 2024 at 6:03 PM
For your consideration:
Careful description, with no statistical comparisons, still brought a number of lasting truths to the table in this first comprehensive description of BPD…
3/6
Careful description, with no statistical comparisons, still brought a number of lasting truths to the table in this first comprehensive description of BPD…
3/6
From the article: “The two outstanding findings are the prolongation of the healing phase of [RDS} and the appearance of a new chronic pulmonary syndrome that is associated with intermittent positive pressure respirators and High Oxygen for longer than one hundred and fifty hours (six days).”
2/6...
2/6...
December 21, 2024 at 6:03 PM
From the article: “The two outstanding findings are the prolongation of the healing phase of [RDS} and the appearance of a new chronic pulmonary syndrome that is associated with intermittent positive pressure respirators and High Oxygen for longer than one hundred and fifty hours (six days).”
2/6...
2/6...
#52MoreChallenge Week 4!
Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967; 276(7):357. PMID: 5334613.
pubmed.ncbi.nlm.nih.gov/5334613/
#neoSky #neoEBM #52MoreChallenge
1/6...
Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967; 276(7):357. PMID: 5334613.
pubmed.ncbi.nlm.nih.gov/5334613/
#neoSky #neoEBM #52MoreChallenge
1/6...
December 21, 2024 at 6:03 PM
#52MoreChallenge Week 4!
Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967; 276(7):357. PMID: 5334613.
pubmed.ncbi.nlm.nih.gov/5334613/
#neoSky #neoEBM #52MoreChallenge
1/6...
Northway WH Jr, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967; 276(7):357. PMID: 5334613.
pubmed.ncbi.nlm.nih.gov/5334613/
#neoSky #neoEBM #52MoreChallenge
1/6...
ROBINS-I v2: www.riskofbias.info/welcome/robi...
Risk of bias tools - ROBINS-I V2 tool
We are pleased to announce Version 2 of the ROBINS-I tool, launched on 22 November 2024.
Access the tool here:
ROBINS-I V2 (editable document) or ROBINS-I V2 (PDF document)
The Risk Of Bias In Non-...
www.riskofbias.info
December 21, 2024 at 5:54 PM
ROBINS-I v2: www.riskofbias.info/welcome/robi...
GRADE obviously also supports this broadly within a given review at the body-of-literature level.
I am not sure that we have Cochrane NRSI SRMA examples in neonatology yet. Might be worth taking one on in the above area as a pilot?
I am not sure that we have Cochrane NRSI SRMA examples in neonatology yet. Might be worth taking one on in the above area as a pilot?
December 21, 2024 at 5:52 PM
GRADE obviously also supports this broadly within a given review at the body-of-literature level.
I am not sure that we have Cochrane NRSI SRMA examples in neonatology yet. Might be worth taking one on in the above area as a pilot?
I am not sure that we have Cochrane NRSI SRMA examples in neonatology yet. Might be worth taking one on in the above area as a pilot?
But there has always been rx evidence beyond RCTs (just think what we got from the Framingham study). Cochrane has expanded its charter to non-randomised studies of the effects of interventions (NRSIs) and is developing tools to support that endeavor (eg see the observational RoB tool ROBINS-I v2)
December 21, 2024 at 5:52 PM
But there has always been rx evidence beyond RCTs (just think what we got from the Framingham study). Cochrane has expanded its charter to non-randomised studies of the effects of interventions (NRSIs) and is developing tools to support that endeavor (eg see the observational RoB tool ROBINS-I v2)
It's such an important point @briankingneo.bsky.social . SRMAs with few or no RCTs are of course an essential part of the evidence synthesis process - I suspect that @souvikneo.bsky.social's review might find itself into the rationale for a new CIHR trial application or two :)
December 21, 2024 at 5:52 PM
It's such an important point @briankingneo.bsky.social . SRMAs with few or no RCTs are of course an essential part of the evidence synthesis process - I suspect that @souvikneo.bsky.social's review might find itself into the rationale for a new CIHR trial application or two :)
Great! Dr. Saigal is always happy to hear from people if you have questions or comments.
December 11, 2024 at 7:07 PM
Great! Dr. Saigal is always happy to hear from people if you have questions or comments.
Reposted by John Zupancic
I guess it's not surprising that our organizations and journals must lag a bit in adoption of a new platform, but they are an important part of the conversation. Let's encourage whatever we're affiliated with to take the leap. We can log them here (currently pretty sparse)
go.bsky.app/DwfZqQF
go.bsky.app/DwfZqQF
November 20, 2024 at 12:22 AM
I guess it's not surprising that our organizations and journals must lag a bit in adoption of a new platform, but they are an important part of the conversation. Let's encourage whatever we're affiliated with to take the leap. We can log them here (currently pretty sparse)
go.bsky.app/DwfZqQF
go.bsky.app/DwfZqQF
Reposted by John Zupancic
🌟 Save the Date! 🌟
Join us for the inaugural Congress of the European Paediatric Academic Societies (CEPAS) in Lyon, France, from 28–31 October 2026. Mission: Uniting paediatric professionals to advance child health through cutting-edge research, education, and collaboration.👉Learn more at cepas.org
Join us for the inaugural Congress of the European Paediatric Academic Societies (CEPAS) in Lyon, France, from 28–31 October 2026. Mission: Uniting paediatric professionals to advance child health through cutting-edge research, education, and collaboration.👉Learn more at cepas.org
Congress of the European Paediatric Academic Societies 2026
Welcome to CEPAS 2026 where we unite paediatric professionals in advancing child health through cuttingedge research, education, and collaboration.
cepas.org
December 10, 2024 at 5:56 PM
🌟 Save the Date! 🌟
Join us for the inaugural Congress of the European Paediatric Academic Societies (CEPAS) in Lyon, France, from 28–31 October 2026. Mission: Uniting paediatric professionals to advance child health through cutting-edge research, education, and collaboration.👉Learn more at cepas.org
Join us for the inaugural Congress of the European Paediatric Academic Societies (CEPAS) in Lyon, France, from 28–31 October 2026. Mission: Uniting paediatric professionals to advance child health through cutting-edge research, education, and collaboration.👉Learn more at cepas.org
(The #52MoreChallenge is a follow-up of the #52in52RCTChallenge. We're currently replaying the first month from Twitter and will start new articles in week 5. If you have candidates for the 52 most important non-RCT articles in the #NeoSky literature, please let me know)
December 10, 2024 at 10:00 PM
(The #52MoreChallenge is a follow-up of the #52in52RCTChallenge. We're currently replaying the first month from Twitter and will start new articles in week 5. If you have candidates for the 52 most important non-RCT articles in the #NeoSky literature, please let me know)
Reposted by John Zupancic
The next AAP SONPM Journal Club is Thursday (December 12th) at 4:00 pm EST. Andrew Beverstock, neonatal fellow, will review the Diamond trial, with mentors Tanith Alexander (trial investigator) and Ariel Salas. #neosky #neoEBM
Register - tinyurl.com/c87skbeh
Trial- nejm.org/doi/full/10.10…
Register - tinyurl.com/c87skbeh
Trial- nejm.org/doi/full/10.10…
December 10, 2024 at 9:22 PM
The next AAP SONPM Journal Club is Thursday (December 12th) at 4:00 pm EST. Andrew Beverstock, neonatal fellow, will review the Diamond trial, with mentors Tanith Alexander (trial investigator) and Ariel Salas. #neosky #neoEBM
Register - tinyurl.com/c87skbeh
Trial- nejm.org/doi/full/10.10…
Register - tinyurl.com/c87skbeh
Trial- nejm.org/doi/full/10.10…
Follow-up bonus about follow-up: Dr. Saigal interviewed the now-adult members of the same cohort decades later for a less prosaic, and quite moving, book and accompanying videos. See a.co/d/411zd3u and www.youtube.com/@PreemieVoices (the latter with both 2014 and 2024 interviews)
🧵fin
🧵fin
December 10, 2024 at 9:57 PM
Follow-up bonus about follow-up: Dr. Saigal interviewed the now-adult members of the same cohort decades later for a less prosaic, and quite moving, book and accompanying videos. See a.co/d/411zd3u and www.youtube.com/@PreemieVoices (the latter with both 2014 and 2024 interviews)
🧵fin
🧵fin
From the paper: “Nevertheless, the vast majority of ELBW respondents view their health-related quality of life as quite satisfactory and are difficult to distinguish from controls."
🧵4/5
🧵4/5
December 10, 2024 at 9:57 PM
From the paper: “Nevertheless, the vast majority of ELBW respondents view their health-related quality of life as quite satisfactory and are difficult to distinguish from controls."
🧵4/5
🧵4/5
The participants in this work were part of a long-term, geographically-defined (and therefore low-selection-bias) cohort, also a significant contribution to a literature that had been (and remains) plagued by single-center, short-term studies.
🧵3/5
🧵3/5
December 10, 2024 at 9:57 PM
The participants in this work were part of a long-term, geographically-defined (and therefore low-selection-bias) cohort, also a significant contribution to a literature that had been (and remains) plagued by single-center, short-term studies.
🧵3/5
🧵3/5
Dr. Saroj Saigal took to heart the insight that EBM includes not only critical appraisal but also patient values & preferences. Her research used tools f/ economics & psychology to demonstrate that patients & families may have different impressions of their own 'medical sequelae' than expected.
🧵2/5
🧵2/5
December 10, 2024 at 9:57 PM
Dr. Saroj Saigal took to heart the insight that EBM includes not only critical appraisal but also patient values & preferences. Her research used tools f/ economics & psychology to demonstrate that patients & families may have different impressions of their own 'medical sequelae' than expected.
🧵2/5
🧵2/5