I've spent many afternoons crouched over a microscope with a pipette, waiting for the exact right moment to add my perturbation (& not breathing so I don't bump anything). Now I can just program it in and have a more relaxing experiment :)

I'm excited to be hiring an intern to develop new fluorescence-based assays for alpha synuclein aggregation at Calico during summer 2026 😃 🔬

If you're a current PhD student who loves microscopy, unnatural amino acids, and/or synuclein biophysics, please apply!

www.calicolabs.com/careers/?gh_...

Want to measure protein-protein interactions? We recently did some dreaming about how you can do this with a single fluorescent tag using molecular "tumbling." We simulated how you'd do this on a lightsheet, a flow cytometer, or a cheap handheld device. We even took prelim data on a commercial rig:

I no longer have the follower count nor the algorithm to help promote stuff, but @jlazzaridean.bsky.social and Andy York reached out to me a while ago to do an animation explaining a way to measure moluecular "tumbling" and I think it worked out pretty well! andrewgyork.github.io/tumbling_is_...

Hi bluesky! Excited to share some new work in voltage sensing I was a part of in my past life in the Evan Miller lab at Berkeley: a versatile dye for both fast voltage imaging and lifetime-based quantification

Introducing CRhOMe: www.biorxiv.org/content/10.1...