J Lucas Argueso
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jlargueso.bsky.social
J Lucas Argueso
@jlargueso.bsky.social
Professional Geneticist, Amateur Explorer
Reposted by J Lucas Argueso
Is this thing still on?

Anyway, we have a new preprint out of a story that's been brewing in my lab for several years and is finally ready to see the light of day. It's about what happens to Candida glabrata while it's hanging out inside macrophages.
Candida glabrata replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability https://www.biorxiv.org/content/10.1101/2025.09.15.676333v1
September 17, 2025 at 3:34 PM
The preprint for our super fun collaboration with Erika Shor @mutant-fungus.bsky.social is out. Check it out to see some really beautiful PFGE karyotyping gels from Candida glabrata!
Candida glabrata replicating within macrophages experiences amino acid deprivation, DNA damage, and chromosome instability https://www.biorxiv.org/content/10.1101/2025.09.15.676333v1
September 19, 2025 at 4:56 PM
Reposted by J Lucas Argueso
📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....
June 9, 2025 at 1:02 PM
Quote post with a picture you took in a National Park.

Aurora Borealis at Yellowstone National Park, seen from my campsite at Slough Creek Campground, October 11 2024, 1:37AM MDT.
February 25, 2025 at 12:52 PM
Reposted by J Lucas Argueso
8/8. So, if you’re feeling down about these attacks, I understand—I feel that way too. But just remember that they’re not attacking because your work doesn’t matter; they’re attacking *precisely* because it does. So, get some rest, connect with your people, and keep doing it.
February 8, 2025 at 8:42 PM
Reposted by J Lucas Argueso
Delighted to publish my new molecular animation:

DNA Break Repair by Homologous Recombination

youtu.be/Xe-83tBcxhs
DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv
YouTube video by WEHImovies
youtu.be
December 4, 2024 at 12:07 AM
Happy US Thanksgiving Day!
November 28, 2024 at 7:42 PM