Chang Jiang
@jianglab2023.bsky.social
Assistant Member @ Department of Molecular Oncology
Moffitt Cancer Center and Research Institute
Lab: https://lab.moffitt.org/jiang/
Moffitt Cancer Center and Research Institute
Lab: https://lab.moffitt.org/jiang/
Pinned
Chang Jiang
@jianglab2023.bsky.social
· Apr 12
The Jiang lab@Moffitt is attending @ASBMB! If you are interested in redox biology and cancer metabolism, check out our posters as listed below on Monday, April 14th, 2025! See you in Chicago! We are hiring now!
Reposted by Chang Jiang
New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Induced ubiquitination bypasses canonical ERAD to drive ER protein degradation
Heterobifunctional proteolysis-targeting chimeras (PROTACs) have emerged as a powerful strategy to degrade disease-relevant proteins, enabling targeting of previously "undruggable" proteins. Current d...
www.biorxiv.org
December 1, 2025 at 5:14 PM
New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Chang Jiang
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer
Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...
www.biorxiv.org
September 9, 2025 at 9:38 PM
Super excited to share our new preprint from @cssheehan.bsky.social on how the tumor microenvironment causes drug resistance in pancreatic cancer: www.biorxiv.org/content/10.1...
New PI life: competing with the “big labs” for rotation students feels like bringing a salad to a pizza party. 🍕🥗 No takers this round, but we’ll keep cooking 💪— the right students will come🫵
September 10, 2025 at 12:30 AM
New PI life: competing with the “big labs” for rotation students feels like bringing a salad to a pizza party. 🍕🥗 No takers this round, but we’ll keep cooking 💪— the right students will come🫵
The Jiang lab@Moffitt is attending @ASBMB! If you are interested in redox biology and cancer metabolism, check out our posters as listed below on Monday, April 14th, 2025! See you in Chicago! We are hiring now!
April 12, 2025 at 6:55 PM
The Jiang lab@Moffitt is attending @ASBMB! If you are interested in redox biology and cancer metabolism, check out our posters as listed below on Monday, April 14th, 2025! See you in Chicago! We are hiring now!