Jack Holcombe
@jackholcombe.bsky.social
Pinned
Jack Holcombe
@jackholcombe.bsky.social
· Sep 28
Such an amazing experience sharing science with a wonderful community! Thanks so much 🧬🔬@edrc2025.bsky.social @fly-eds.bsky.social
Reposted by Jack Holcombe
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
November 3, 2025 at 2:46 PM
🚨 Come join us @sheffielduni.bsky.social for a PhD on the evolution and development of feathers and flight! 🐣🔬
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
This project is supervised by @matt-towers.bsky.social & @alexgfletcher.bsky.social, and I'm excited to be involved as a project advisor. Please share!
www.findaphd.com/phds/project... 🧪
Reposted by Jack Holcombe
@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Visceral signaling of post-ingestive malaise directs memory updating in Drosophila
Consolidation is a time when labile memories transition to a stable form. Malaise learning in Drosophila reveals consolidation to also permit memory updating. Flies taught to associate one of two odor...
www.biorxiv.org
October 23, 2025 at 8:32 PM
@senapati.bsky.social latest and greatest! Charly Treiber on board too. Over and out.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jack Holcombe
AWS is down, post hog
October 20, 2025 at 10:05 AM
AWS is down, post hog
Reposted by Jack Holcombe
Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby.
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
These ancient bumblebees were found with their pollen source
Insects have long pollinated plants, but evidence of ancient pairing is rare. Fossils now show bees and linden trees goes back 24 million years.
www.sciencenews.org
October 15, 2025 at 6:22 PM
Scientists just found several fossil bumblebees covered in pollen that directly matches fossil flowers nearby.
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
The 24-million-year-old discovery reveals the oldest known evidence connecting pollinators to the pollinated.
#Paleontology #NationalFossilDay
🧪🏺
New at @sciencenews.bsky.social
Reposted by Jack Holcombe
Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
October 9, 2025 at 3:27 PM
Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jack Holcombe
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
October 8, 2025 at 8:49 AM
John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died.
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology.
More: www2.mrc-lmb.cam.ac.uk/john-gurdon-...
#LMBNews
Reposted by Jack Holcombe
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
September 30, 2025 at 2:43 PM
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
Reposted by Jack Holcombe
I wrote something on developmental biology and disability and put it up on the node last night:
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
Developmental Biology and Disability - the Node
Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.
thenode.biologists.com
September 30, 2025 at 9:38 AM
I wrote something on developmental biology and disability and put it up on the node last night:
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
thenode.biologists.com/developmenta...
I've been nervous to share because some of it veers a bit personal but they are thoughts that won't stay quiet. Would love to know what people think about it!
Reposted by Jack Holcombe
Some amazing talks but highlights for me were David Bilder on innate immune-tumour interactions, @jackholcombe.bsky.social ‘s PhD prize tour de force and exciting and beautiful data and new tools to look at basement membrane and clotting hot out of @stramerlab.bsky.social
September 30, 2025 at 9:07 AM
Some amazing talks but highlights for me were David Bilder on innate immune-tumour interactions, @jackholcombe.bsky.social ‘s PhD prize tour de force and exciting and beautiful data and new tools to look at basement membrane and clotting hot out of @stramerlab.bsky.social
Reposted by Jack Holcombe
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
September 29, 2025 at 7:09 PM
Happy to share the inaugural paper from the lab. We describe a molecular mechanism for the activation of outer dynein arm motors that power the vital motion of cilia.
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Open access link below:
www.nature.com/articles/s41...
Here's a cool animated summary
Such an amazing experience sharing science with a wonderful community! Thanks so much 🧬🔬@edrc2025.bsky.social @fly-eds.bsky.social
September 28, 2025 at 4:41 PM
Such an amazing experience sharing science with a wonderful community! Thanks so much 🧬🔬@edrc2025.bsky.social @fly-eds.bsky.social
Reposted by Jack Holcombe
This is the organizing team behind #EDRC2025 María Dominguez, Javier Morante @morantelab.bsky.social , Juan Sanchez-Alcaniz @sanchezalcaniz.bsky.social , Pepe Pastor-Pareja @pastorparejalab.bsky.social and Ana Carmena
September 26, 2025 at 3:44 PM
This is the organizing team behind #EDRC2025 María Dominguez, Javier Morante @morantelab.bsky.social , Juan Sanchez-Alcaniz @sanchezalcaniz.bsky.social , Pepe Pastor-Pareja @pastorparejalab.bsky.social and Ana Carmena
Reposted by Jack Holcombe
We are loving the
@edrc2025.bsky.social !!
Please come find us at the poster sessions and coffee breaks!
@edrc2025.bsky.social !!
Please come find us at the poster sessions and coffee breaks!
September 26, 2025 at 7:37 AM
We are loving the
@edrc2025.bsky.social !!
Please come find us at the poster sessions and coffee breaks!
@edrc2025.bsky.social !!
Please come find us at the poster sessions and coffee breaks!
Reposted by Jack Holcombe
If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025
September 25, 2025 at 9:20 AM
If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025
Reposted by Jack Holcombe
This is great news.
Though 'reviewed preprints" does feel a bit dated by now. Last year a few people asked me why EMBO still only accepted reviewed preprints.
Though 'reviewed preprints" does feel a bit dated by now. Last year a few people asked me why EMBO still only accepted reviewed preprints.
HHMI adopts Plan U journals.plos.org/plosbiology/...
September 24, 2025 at 6:21 PM
This is great news.
Though 'reviewed preprints" does feel a bit dated by now. Last year a few people asked me why EMBO still only accepted reviewed preprints.
Though 'reviewed preprints" does feel a bit dated by now. Last year a few people asked me why EMBO still only accepted reviewed preprints.
Reposted by Jack Holcombe
“Trump's Harvard cuts threaten a giant in the biomedical research community: A database about the tiny fruit fly”
The FlyBase grant is run through the Perrimon lab at HMS, so when Trump cut off 100% of our NIH $, it causes existential risk to the entire community
www.nbcnews.com/science/scie...
The FlyBase grant is run through the Perrimon lab at HMS, so when Trump cut off 100% of our NIH $, it causes existential risk to the entire community
www.nbcnews.com/science/scie...
Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly
This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.
www.nbcnews.com
September 16, 2025 at 12:59 PM
“Trump's Harvard cuts threaten a giant in the biomedical research community: A database about the tiny fruit fly”
The FlyBase grant is run through the Perrimon lab at HMS, so when Trump cut off 100% of our NIH $, it causes existential risk to the entire community
www.nbcnews.com/science/scie...
The FlyBase grant is run through the Perrimon lab at HMS, so when Trump cut off 100% of our NIH $, it causes existential risk to the entire community
www.nbcnews.com/science/scie...
Reposted by Jack Holcombe
Specifically on the #metascience side, congrats to @josephlemaitre.bsky.social and @brunolemaitre.bsky.social on this consequential piece. 🎉
By dissecting factors associated with #reproducibility within a single field, there are broad lessons for #ScientificPublishing and broader #science.
By dissecting factors associated with #reproducibility within a single field, there are broad lessons for #ScientificPublishing and broader #science.
July 10, 2025 at 12:58 PM
Specifically on the #metascience side, congrats to @josephlemaitre.bsky.social and @brunolemaitre.bsky.social on this consequential piece. 🎉
By dissecting factors associated with #reproducibility within a single field, there are broad lessons for #ScientificPublishing and broader #science.
By dissecting factors associated with #reproducibility within a single field, there are broad lessons for #ScientificPublishing and broader #science.
Reposted by Jack Holcombe
🔬New paper! This has been my personal favorite project I’ve ever done - also, the only one that the President has been relentlessly trying to destroy by 100% defunding our lab & institution. Please enjoy:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 3, 2025 at 12:31 PM
🔬New paper! This has been my personal favorite project I’ve ever done - also, the only one that the President has been relentlessly trying to destroy by 100% defunding our lab & institution. Please enjoy:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jack Holcombe
Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.
thenode.biologists.com/event-carbon...
thenode.biologists.com/event-carbon...
Event carbon calculator - the Node
I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your
thenode.biologists.com
July 1, 2025 at 10:01 AM
Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.
thenode.biologists.com/event-carbon...
thenode.biologists.com/event-carbon...
Reposted by Jack Holcombe
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 11:21 AM
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
So honoured to receive this prize! Really looking forward to EDRC!
Congratulations to the winner of the #EDS best PhD thesis prize Jack Holcombe, for his work "Dissecting Stress Resilience Mechanisms During Epithelial Homeostasis and Repair” conducted in the lab of Helen Weavers at the University of Bristol europeandrosophilasociety.org/eds-best-phd...
June 23, 2025 at 9:31 AM
So honoured to receive this prize! Really looking forward to EDRC!
Reposted by Jack Holcombe
Congratulations to @jackholcombe.bsky.social for his #EDS best PhD thesis award! Jack will give a plenary talk at #EDRC2025
June 13, 2025 at 6:24 PM
Congratulations to @jackholcombe.bsky.social for his #EDS best PhD thesis award! Jack will give a plenary talk at #EDRC2025
Reposted by Jack Holcombe
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Job Search | Cardiff University
Search for Internet job results.
krb-sjobs.brassring.com
June 11, 2025 at 10:35 AM
✨️ Come join my lab! ✨️ I have an ARUK funded post doc position available for a talented ECR to work with Drosophila and human iPSC derived neurons.
krb-sjobs.brassring.com/TGnewUI/Sear...
krb-sjobs.brassring.com/TGnewUI/Sear...
Reposted by Jack Holcombe
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
June 3, 2025 at 9:17 PM
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.