Javier Alonso del Real
@jaalodar.bsky.social
Researcher. Currently devoted to study MTB genomics at tgu.ibv.csic.es. Valencia, Spain.
Reposted by Javier Alonso del Real
BUSCO v6.0.0 has been released. busco.ezlab.org
BUSCO - from QC to gene prediction and phylogenomics
from QC to gene prediction and phylogenomics
busco.ezlab.org
July 11, 2025 at 9:29 PM
BUSCO v6.0.0 has been released. busco.ezlab.org
Reposted by Javier Alonso del Real
Our latest paper, in which @brinda.eu (along with @zaminiqbal.bsky.social and others) introduces phylogenetic compression for storage and search of enormous microbial genome libraries, was published today in @naturemethods.bsky.social:
rdcu.be/eg4OA
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rdcu.be/eg4OA
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Efficient and robust search of microbial genomes via phylogenetic compression
Nature Methods - Phylogenetic compression achieves performant and lossless compression of massive collections of microbial genomes, facilitating fast BLAST-like search and versatile alignment tasks.
rdcu.be
April 9, 2025 at 9:07 PM
Our latest paper, in which @brinda.eu (along with @zaminiqbal.bsky.social and others) introduces phylogenetic compression for storage and search of enormous microbial genome libraries, was published today in @naturemethods.bsky.social:
rdcu.be/eg4OA
1/
rdcu.be/eg4OA
1/
Reposted by Javier Alonso del Real
1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome duplication in a long-term multicellularity evolution experiment - Nature
In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...
www.nature.com
March 5, 2025 at 11:00 PM
1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Javier Alonso del Real
Science affords us the luxury of forgetting the impact of infectious diseases
- In the 1st half of the 19th century 40-50% of children in US did not make it past the age of 5
- TB killed 1 in 7 people in US and Europe
- smallpox killed 80% of infected children
theconversation.com/infectious-d...
- In the 1st half of the 19th century 40-50% of children in US did not make it past the age of 5
- TB killed 1 in 7 people in US and Europe
- smallpox killed 80% of infected children
theconversation.com/infectious-d...
Infectious diseases killed Victorian children at alarming rates — their novels highlight the fragility of public health today
Between 40% and 50% of children didn’t live past 5 in the US during the 19th century. Popular authors like Charles Dickens documented the common but no less gutting grief of losing a child.
theconversation.com
December 29, 2024 at 5:34 PM
Science affords us the luxury of forgetting the impact of infectious diseases
- In the 1st half of the 19th century 40-50% of children in US did not make it past the age of 5
- TB killed 1 in 7 people in US and Europe
- smallpox killed 80% of infected children
theconversation.com/infectious-d...
- In the 1st half of the 19th century 40-50% of children in US did not make it past the age of 5
- TB killed 1 in 7 people in US and Europe
- smallpox killed 80% of infected children
theconversation.com/infectious-d...
Reposted by Javier Alonso del Real
We built a new tool for disentangling local haplotypes from long-read sequencing: check out devider! github.com/bluenote-157...
www.biorxiv.org/content/10.1...
1/5
www.biorxiv.org/content/10.1...
1/5
devider: long-read reconstruction of many diverse haplotypes
Reconstructing haplotypes is important when sequencing a mixture of similar sequences. Long-read sequencing can connect distant alleles to disentangle similar haplotypes, but handling se-quencing erro...
www.biorxiv.org
December 17, 2024 at 11:32 PM
We built a new tool for disentangling local haplotypes from long-read sequencing: check out devider! github.com/bluenote-157...
www.biorxiv.org/content/10.1...
1/5
www.biorxiv.org/content/10.1...
1/5
Reposted by Javier Alonso del Real
(1/5) Traditionally, antibiotic discovery has centered on bacteria and fungi—until now.
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
December 12, 2024 at 10:56 AM
(1/5) Traditionally, antibiotic discovery has centered on bacteria and fungi—until now.
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds. www.biorxiv.org/content/10.1...
Reposted by Javier Alonso del Real
For her PhD work, Carla Bautista in our group discovered that yeast hybrids adapted slower to stressful conditions, and she figured out why. See what she found here. #evolution www.nature.com/articles/s41...
Hybrid adaptation is hampered by Haldane’s sieve - Nature Communications
Hybrids have complex genomes that influence their adaptive potential. This study reveals that yeast hybrids adapt slower than their parental species in a new environment, primarily due to a reduced ra...
www.nature.com
November 28, 2024 at 12:18 PM
For her PhD work, Carla Bautista in our group discovered that yeast hybrids adapted slower to stressful conditions, and she figured out why. See what she found here. #evolution www.nature.com/articles/s41...
Reposted by Javier Alonso del Real
What did the Last Eukaryotic Common Ancestor (#LECA) look like? Consensus View in #PLOSBiology; massive authorship including @AncestralState, @lauraeme.bsky.social, John Archbald, @andrewjroger.bsky.social, @dackslabecb.bsky.social, Jeremy Wideman. plos.io/4g0alq4
November 25, 2024 at 7:29 PM
What did the Last Eukaryotic Common Ancestor (#LECA) look like? Consensus View in #PLOSBiology; massive authorship including @AncestralState, @lauraeme.bsky.social, John Archbald, @andrewjroger.bsky.social, @dackslabecb.bsky.social, Jeremy Wideman. plos.io/4g0alq4
Very happy to enroll Momentum program at tgu.ibv.csic.es @ibv-csic.bsky.social. Spanish Research council @csic.es created such program to build and attract capacities in edge technologies for digitization such as AI.
November 25, 2024 at 12:31 PM
Very happy to enroll Momentum program at tgu.ibv.csic.es @ibv-csic.bsky.social. Spanish Research council @csic.es created such program to build and attract capacities in edge technologies for digitization such as AI.
Reposted by Javier Alonso del Real
And today in, well, no shit:
Bacteria found on asteroid was actually Earthly contamination, scientists report www.salon.com/2024/11/24/b...
Bacteria found on asteroid was actually Earthly contamination, scientists report www.salon.com/2024/11/24/b...
Bacteria found on asteroid was actually Earthly contamination, scientists report
A new study of samples from Ryugu found that microorganisms can avoid even stringent contamination controls
www.salon.com
November 24, 2024 at 4:14 PM
And today in, well, no shit:
Bacteria found on asteroid was actually Earthly contamination, scientists report www.salon.com/2024/11/24/b...
Bacteria found on asteroid was actually Earthly contamination, scientists report www.salon.com/2024/11/24/b...
Reposted by Javier Alonso del Real
"92 million low-income people in the U.S. states—everyone whose income is less than 200 percent of the federal poverty line—have some basic aspect of their lives decided by AI"
www.techtonicjustice.org/reports/ines...
this is a damning report
www.techtonicjustice.org/reports/ines...
this is a damning report
November 23, 2024 at 11:37 AM
"92 million low-income people in the U.S. states—everyone whose income is less than 200 percent of the federal poverty line—have some basic aspect of their lives decided by AI"
www.techtonicjustice.org/reports/ines...
this is a damning report
www.techtonicjustice.org/reports/ines...
this is a damning report
Reposted by Javier Alonso del Real
A valuable and well done community resource following #OpenScience principles academic.oup.com/g3journal/ad...
Overview of the Saccharomyces cerevisiae population structure through the lens of 3,034 genomes
Abstract. With the rise of high-throughput sequencing technologies, a holistic view of genetic variation within populations—through population genomics stu
academic.oup.com
November 22, 2024 at 9:55 AM
A valuable and well done community resource following #OpenScience principles academic.oup.com/g3journal/ad...
Reposted by Javier Alonso del Real
Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇
November 22, 2024 at 11:05 AM
Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇
Reposted by Javier Alonso del Real
Cuando llegamos al Gobierno en 2020 no se podía multar a las grandes empresas. Nos costó 3 años -y mucho sufrimiento- aprobar la ley para poder hacerlo. Hoy el brillante @pbustinduy.bsky.social culmina ese trabajo con noticias como esta. ¡Enhorabuena! cadenaser.com/nacional/202...
El Gobierno multa con 179 millones de euros a las aerolíneas de bajo coste por cobrar el equipaje de mano y la impresión de billetes
Ryanair tendrá que asumir el 60% de la cuantía de esta multa, que ha adelantado la Cadena SER, con la que el Ministerio de Consumo busca disuadir a las 'low cost' de que sigan cobrando como ...
cadenaser.com
November 22, 2024 at 8:12 AM
Cuando llegamos al Gobierno en 2020 no se podía multar a las grandes empresas. Nos costó 3 años -y mucho sufrimiento- aprobar la ley para poder hacerlo. Hoy el brillante @pbustinduy.bsky.social culmina ese trabajo con noticias como esta. ¡Enhorabuena! cadenaser.com/nacional/202...
Reposted by Javier Alonso del Real
Reposted by Javier Alonso del Real
Para entender por qué el PNV quiere hacer un regalo fiscal a las empresas más contaminantes de España justo después de la DANA de Valencia y por qué Aitor Esteban dispara agresivamente contra Podemos por oponerse, lo mejor es buscar a Josu Jon Imaz en Wikipedia.
November 18, 2024 at 12:20 PM
Para entender por qué el PNV quiere hacer un regalo fiscal a las empresas más contaminantes de España justo después de la DANA de Valencia y por qué Aitor Esteban dispara agresivamente contra Podemos por oponerse, lo mejor es buscar a Josu Jon Imaz en Wikipedia.
Reposted by Javier Alonso del Real
Latest data from AllTheBacteria described in our updated preprint. All illumina WGS bacterial+archaeal sequence data to Aug 2024 consistently assembled, QC, and now AMR profiling. That's 2.4 million genomes. Gene annotations almost done , coming next. Please use!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
AllTheBacteria - all bacterial genomes assembled, available and searchable
The bacterial sequence data publicly available at the global DNA archives is a vast source of information on the evolution of bacteria and their mobile elements. However, most of it is either unassemb...
www.biorxiv.org
November 15, 2024 at 6:59 PM
Latest data from AllTheBacteria described in our updated preprint. All illumina WGS bacterial+archaeal sequence data to Aug 2024 consistently assembled, QC, and now AMR profiling. That's 2.4 million genomes. Gene annotations almost done , coming next. Please use!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Javier Alonso del Real
En verano escribí un texto sobre la historia de internet y la tensión entre protocolos abiertos y plataformas cerrados, en el que entro un poco en cómo funciona Bluesky/atproto: amalgama.ghost.io/protocolos-r...
Protocolos, redes sociales, democracia
I. La red precursora de internet nace en Estados Unidos a finales de la década de 1960 con el objetivo de facilitar la comunicación y el uso compartido de recursos informáticos escasos entre centros d...
amalgama.ghost.io
November 14, 2024 at 7:39 PM
En verano escribí un texto sobre la historia de internet y la tensión entre protocolos abiertos y plataformas cerrados, en el que entro un poco en cómo funciona Bluesky/atproto: amalgama.ghost.io/protocolos-r...
Cuando alguien publique "para cuándo la opción de editar el tweet?", sabremos que esto también se estará yendo a la mierda.
November 14, 2024 at 4:01 PM
Cuando alguien publique "para cuándo la opción de editar el tweet?", sabremos que esto también se estará yendo a la mierda.
Me han dicho que esto está a prueba de naziolos...
November 14, 2024 at 3:27 PM
Me han dicho que esto está a prueba de naziolos...