@isbbonn.bsky.social
New article on @biorxiv-immuno.bsky.social: our study on a first-in-class family of #NLRP3 inhibitors: CNS-penetrating indazole scaffolds! #BAL-compounds
Inhibition of NLRP3 by a CNS-penetrating indazole scaffold https://www.biorxiv.org/content/10.1101/2025.07.01.662566v1
July 5, 2025 at 4:10 PM
New article on @biorxiv-immuno.bsky.social: our study on a first-in-class family of #NLRP3 inhibitors: CNS-penetrating indazole scaffolds! #BAL-compounds
Reposted
Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins
Artificial intelligence (AI)-based protein design opens new avenues for the rapid generation of new research tools and therapeutics, but experimental validation lags behind the computational design th...
www.biorxiv.org
May 18, 2025 at 5:06 PM
Happy to share our first foray into the world of AI-based #ProteinDesign. www.biorxiv.org/content/10.1...
Reposted
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins https://www.biorxiv.org/content/10.1101/2025.05.11.652819v1
May 15, 2025 at 8:46 PM
Development of AI-designed protein binders for detection and targeting of cancer cell surface proteins https://www.biorxiv.org/content/10.1101/2025.05.11.652819v1
New paper out on Chemical Communications:
"Degrading the key component of the inflammasome: development of an NLRP3 PROTAC"
doi.org/10.1039/D4CC...
"Degrading the key component of the inflammasome: development of an NLRP3 PROTAC"
doi.org/10.1039/D4CC...
Degrading the key component of the inflammasome: development of an NLRP3 PROTAC
This study explores PROTACs for NLRP3, the key player in innate immunity. We utilised a thiophene analogue of the NLRP3 inhibitor MCC950 and employed CuAAC chemistry for the assembly of PROTACs bearin...
doi.org
January 24, 2025 at 8:52 AM
New paper out on Chemical Communications:
"Degrading the key component of the inflammasome: development of an NLRP3 PROTAC"
doi.org/10.1039/D4CC...
"Degrading the key component of the inflammasome: development of an NLRP3 PROTAC"
doi.org/10.1039/D4CC...
Reposted
Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action https://www.biorxiv.org/content/10.1101/2024.12.21.629867v1
December 23, 2024 at 3:16 AM
Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action https://www.biorxiv.org/content/10.1101/2024.12.21.629867v1