ImmunoHorizons
@immunohorizons.bsky.social
ImmunoHorizons is the #OpenAccess, fully peer-reviewed journal of The American Association of Immunologists, Inc. @immunologyaai.bsky.social
Editor-in-Chief: Bonnie N. Dittel, Ph.D.
Editor-in-Chief: Bonnie N. Dittel, Ph.D.
Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h
Tumor cells upregulate CCL22 in a STING-dependent manner in response to paracrine factors released by STING-activated myeloid cells and type I interferons
Abstract. Immunosuppressive elements within the tumor microenvironment include both regulatory T cells (Tregs) and M2 macrophages. A well-described mechani
ow.ly
November 6, 2025 at 6:59 PM
Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h
The synergistic activity of LIGHT with other classical cytokines was observed to regulate transcription in pulmonary fibroblasts and suggests the involvement of LIGHT in shaping fibroblast phenotypes observed in chronic lung disease.
🔗 ow.ly/pGOn50Xmwlq.
#OpenAccess
🔗 ow.ly/pGOn50Xmwlq.
#OpenAccess
LIGHT in combination with IL-13 or IL-17 drives inflammatory transcriptional signatures in human pulmonary fibroblasts relevant for human lung disease
Abstract. Fibroblasts are structural cells primarily involved in tissue remodeling, but recent single-cell RNA sequencing (RNA-seq) transcriptomic data hav
ow.ly
November 5, 2025 at 8:55 PM
The synergistic activity of LIGHT with other classical cytokines was observed to regulate transcription in pulmonary fibroblasts and suggests the involvement of LIGHT in shaping fibroblast phenotypes observed in chronic lung disease.
🔗 ow.ly/pGOn50Xmwlq.
#OpenAccess
🔗 ow.ly/pGOn50Xmwlq.
#OpenAccess
Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h
November 4, 2025 at 3:31 PM
Researchers found that exogenous type I interferons, a major downstream product of STING activation, also upregulate CCL22 in cancer cells via a STING-dependent mechanism and that exogenous IFN-β can directly activate STING. Learn more in ImmunoHorizons: ow.ly/C11i50Xmw7h
Reposted by ImmunoHorizons
🎃 Happy Halloween! Ever wondered what your immune cells would wear to a costume party?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?
October 31, 2025 at 5:25 PM
🎃 Happy Halloween! Ever wondered what your immune cells would wear to a costume party?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?
🚑 Neutrophil as an EMT: First responder on duty!
🥷 Killer T-Cell as a K-Pop Demon Hunter: Eliminating threats with precision!
What do you think each immune cell would wear for Halloween?
Reposted by ImmunoHorizons
#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.
📘 ow.ly/189i50Xl7h4
📘 ow.ly/189i50Xl7h4
Zombie Ants, Spider Bait, and a Sneaky Burrowing Worm: The 6 Spookiest Science Discoveries of the Past Year
The natural world is full of discoveries that feel straight out of a Tim Burton fever dream.
ow.ly
October 31, 2025 at 5:26 PM
#DYK We published one of the 6 spookiest discoveries of the year according to @zmescience.bsky.social? As a ghost passes through a wall, the parasitic work Schistosoma mansoni can pass through your skin without being detected. Read more: ow.ly/yIUS50Xl7h3.
📘 ow.ly/189i50Xl7h4
📘 ow.ly/189i50Xl7h4
Reposted by ImmunoHorizons
CHPE and metformin can modulate immune responses and improve gland function in mouse model of Sjögren’s disease via interaction with antigen-binding grooves of MHC Class II, with effectiveness varying by sex and age
academic.oup.com/immunohorizo... @immunohorizons.bsky.social
academic.oup.com/immunohorizo... @immunohorizons.bsky.social
August 29, 2025 at 4:04 PM
CHPE and metformin can modulate immune responses and improve gland function in mouse model of Sjögren’s disease via interaction with antigen-binding grooves of MHC Class II, with effectiveness varying by sex and age
academic.oup.com/immunohorizo... @immunohorizons.bsky.social
academic.oup.com/immunohorizo... @immunohorizons.bsky.social
Reposted by ImmunoHorizons
Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.
Join us for IMMUNOLOGY2026™
YouTube video by The American Association of Immunologists (AAI)
youtu.be
October 7, 2025 at 7:09 PM
Get ready for #IMMUNOLOGY2026™! We're heading to the vibrant city of Boston, MA. Prepare for groundbreaking science, incredible networking, and an unforgettable experience. Don't miss your chance to be part of the #immunology community! Learn more: immunology2026.aai.org/abstracts.
Reposted by ImmunoHorizons
🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health.
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
October 1, 2025 at 4:30 PM
🚀 New from AAI: Immunology Explained — a hub for clear, evidence-based insights into how the immune system protects health.
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
Check it out: immunologyexplained.aai.org
Find and follow Immunology Explained on TikTok, Facebook, Instagram and YouTube
#ImmunologyExplained
Reposted by ImmunoHorizons
An essential conversation during #PeerReviewWeek! We hosted the webinar "How to Be the Reviewer You Want to Have," presented by Dr. Gail A. Bishop, EIC of @jimmunol.bsky.social.
It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek
It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek
September 18, 2025 at 9:26 PM
An essential conversation during #PeerReviewWeek! We hosted the webinar "How to Be the Reviewer You Want to Have," presented by Dr. Gail A. Bishop, EIC of @jimmunol.bsky.social.
It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek
It's a key topic for graduate students and post-docs. Watch now: ow.ly/mAXQ50WZ1kH #TBT #PeerReviewWeek
Reposted by ImmunoHorizons
Boost your career with an AAI Travel Award! Open to AAI members, these awards provide funding to attend #IMMUNOLOGY2026™. Submit your abstract and apply for an AAI Travel Award by the October 15 deadline. Learn more: ow.ly/cBuc50WYhwq.
September 18, 2025 at 1:40 PM
Boost your career with an AAI Travel Award! Open to AAI members, these awards provide funding to attend #IMMUNOLOGY2026™. Submit your abstract and apply for an AAI Travel Award by the October 15 deadline. Learn more: ow.ly/cBuc50WYhwq.
Reposted by ImmunoHorizons
Joining us on Capitol Hill Sept 30? Meet our exciting lineup of speakers: Dr. James Allison, world-renowned oncology expert, Dr. Elizabeth Jaffee, and cancer survivor Alexis Browning. They will share their expertise and insights on the impact of immunotherapy. RSVP today: bit.ly/AAI-GA-Brief....
September 16, 2025 at 5:54 PM
Joining us on Capitol Hill Sept 30? Meet our exciting lineup of speakers: Dr. James Allison, world-renowned oncology expert, Dr. Elizabeth Jaffee, and cancer survivor Alexis Browning. They will share their expertise and insights on the impact of immunotherapy. RSVP today: bit.ly/AAI-GA-Brief....
Reposted by ImmunoHorizons
Review @immunohorizons.bsky.social
The cat’s out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense
academic.oup.com/immunohorizo...
The cat’s out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense
academic.oup.com/immunohorizo...
August 29, 2025 at 4:07 PM
Review @immunohorizons.bsky.social
The cat’s out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense
academic.oup.com/immunohorizo...
The cat’s out of the bag: Toxoplasma gondii provides further insight into myeloid-mediated host defense
academic.oup.com/immunohorizo...
New findings provide insight into the dynamics of various immune proteins present in breastmilk and highlight their pivotal roles in determining neonatal immune responses and microbial colonization at early stage. Read all about it: ow.ly/tGcu50W0eG3. #OpenAccess
Dynamics of antimicrobial proteins’ expression and their bactericidal activity in mouse milk
Abstract. Mother’s milk is considered as “complete edible immune system.” It contains macro- and micronutrients required to maintain infant growth and prov
ow.ly
September 3, 2025 at 4:36 PM
New findings provide insight into the dynamics of various immune proteins present in breastmilk and highlight their pivotal roles in determining neonatal immune responses and microbial colonization at early stage. Read all about it: ow.ly/tGcu50W0eG3. #OpenAccess
Reposted by ImmunoHorizons
🚨 IMMUNOLOGY2026™ abstract submissions are now open! Share your groundbreaking research with the global immunology community. Submit your abstract by October 15: immunology2026.aai.org/abstracts
September 3, 2025 at 1:36 PM
🚨 IMMUNOLOGY2026™ abstract submissions are now open! Share your groundbreaking research with the global immunology community. Submit your abstract by October 15: immunology2026.aai.org/abstracts
Reposted by ImmunoHorizons
The latest press release for @immunohorizons.bsky.social showcases new research that paves the way for more personalized veterinary care for dogs that could help dog owners make informed decisions that keep their pets healthier longer. Read it in #AAInews: ow.ly/imSg50WMatf.
August 27, 2025 at 12:44 PM
The latest press release for @immunohorizons.bsky.social showcases new research that paves the way for more personalized veterinary care for dogs that could help dog owners make informed decisions that keep their pets healthier longer. Read it in #AAInews: ow.ly/imSg50WMatf.
Reposted by ImmunoHorizons
🔬 Join us for a webinar on Biomarker Selection and Analysis in Clinical Trials on Sept 2, 4-5 PM ET! Featuring Drs. Allan D. Kirk (@dukehealth.bsky.social) and Katherine P. Liao (@harvardmed.bsky.social). Don't miss out and register now: ow.ly/zAOG50WHPy8 #AAIwebinar #clinicalimmunology #immunosky
August 19, 2025 at 2:50 PM
🔬 Join us for a webinar on Biomarker Selection and Analysis in Clinical Trials on Sept 2, 4-5 PM ET! Featuring Drs. Allan D. Kirk (@dukehealth.bsky.social) and Katherine P. Liao (@harvardmed.bsky.social). Don't miss out and register now: ow.ly/zAOG50WHPy8 #AAIwebinar #clinicalimmunology #immunosky
Reposted by ImmunoHorizons
Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice
@immunohorizons.bsky.social
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@immunohorizons.bsky.social
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July 20, 2025 at 4:34 PM
Aberrant humoral immune responses and intestinal homeostasis in Cd38 Bst1 double knockout mice
@immunohorizons.bsky.social
academic.oup.com/immunohorizo...
@immunohorizons.bsky.social
academic.oup.com/immunohorizo...
Reposted by ImmunoHorizons
The countdown begins to #IMMUNOLOGY2026™ in Boston, MA! In less than two weeks, you can submit your abstract from September 3 – October 15. Start preparing your research today for a chance to present in Boston! immunology2026.aai.org
#immunology #scicomm
#immunology #scicomm
August 18, 2025 at 10:33 AM
The countdown begins to #IMMUNOLOGY2026™ in Boston, MA! In less than two weeks, you can submit your abstract from September 3 – October 15. Start preparing your research today for a chance to present in Boston! immunology2026.aai.org
#immunology #scicomm
#immunology #scicomm
Reposted by ImmunoHorizons
Is your lab at risk due to unexpected federal grant terminations? The AAI RESTORE Grants Program offers up to $100K to help you retain personnel & continue critical immunology research. Deadline Aug 28! Share with your colleagues today: ow.ly/4PWF50WxYt4.
#ScienceFundingCrisis #SupportResearchers
#ScienceFundingCrisis #SupportResearchers
August 18, 2025 at 5:43 PM
Is your lab at risk due to unexpected federal grant terminations? The AAI RESTORE Grants Program offers up to $100K to help you retain personnel & continue critical immunology research. Deadline Aug 28! Share with your colleagues today: ow.ly/4PWF50WxYt4.
#ScienceFundingCrisis #SupportResearchers
#ScienceFundingCrisis #SupportResearchers
Reposted by ImmunoHorizons
A parasitic worm suppresses neurons to evade detection. Researchers from @tulanemedicine.bsky.social say isolating the molecules responsible for the suppression could lead to new painkillers for humans. Read more in the latest press release on AAI News: ow.ly/Agot50WCM2E.
August 13, 2025 at 11:51 AM
A parasitic worm suppresses neurons to evade detection. Researchers from @tulanemedicine.bsky.social say isolating the molecules responsible for the suppression could lead to new painkillers for humans. Read more in the latest press release on AAI News: ow.ly/Agot50WCM2E.
Reposted by ImmunoHorizons
Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg
August 11, 2025 at 2:04 PM
Researchers discovered B cell follicles in nurse shark pancreas and saw antigen-specific antibodies were produced in the pancreas following immunization providing insight into how immune surveillance may function in the absence of lymph nodes. Read more: ow.ly/oF6q50WCKbg
Reposted by ImmunoHorizons
🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
July 31, 2025 at 3:00 PM
🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025.
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
🔗 ow.ly/rwMU50Wy3Mp
#AAIRESTORE
Reposted by ImmunoHorizons
Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.
July 29, 2025 at 3:08 PM
Apply today to participate in the AAI Peer-Review Mentorship Program! This program is designed to provide mentorship from seasoned professionals to develop your skills as a peer reviewer of manuscripts submitted to AAI journals. Learn more: ow.ly/qLyn50WuPxA.
Reposted by ImmunoHorizons
Characterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains
@immunohorizons.bsky.social
academic.oup.com/immunohorizo...
@immunohorizons.bsky.social
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July 20, 2025 at 4:35 PM
Characterization of extensive diversity in immunoglobulin light chain variable germline genes across biomedically important mouse strains
@immunohorizons.bsky.social
academic.oup.com/immunohorizo...
@immunohorizons.bsky.social
academic.oup.com/immunohorizo...
@astra-zeneca.bsky.social evaluated acalabrutinib with supportive care vs. supportive care alone in phase 2 clinical studies of hospitalized patients with #COVID19. No safety concerns and no significant benefit of adding acalabrutinib were reported. Read more in IH: ow.ly/gxE250Wa1fS.
Efficacy and safety of acalabrutinib with best supportive care versus best supportive care in patients with COVID-19 requiring hospitalization
Abstract. The efficacy and safety of acalabrutinib, a Bruton tyrosine kinase (BTK) inhibitor, was evaluated in 2 phase 2 studies in hospitalized patients w
ow.ly
June 18, 2025 at 1:56 PM
@astra-zeneca.bsky.social evaluated acalabrutinib with supportive care vs. supportive care alone in phase 2 clinical studies of hospitalized patients with #COVID19. No safety concerns and no significant benefit of adding acalabrutinib were reported. Read more in IH: ow.ly/gxE250Wa1fS.