idanfrumkin.bsky.social
@idanfrumkin.bsky.social
1/5
Can random sequences encode meaningful functions and allow de novo gene birth? To explore this, Michael Laub and I screened 100 million random genes, without sequence similarity to natural genes, for their ability to rescue growth arrest of E. coli cells producing the ribonuclease toxin MazF.
Can random sequences encode meaningful functions and allow de novo gene birth? To explore this, Michael Laub and I screened 100 million random genes, without sequence similarity to natural genes, for their ability to rescue growth arrest of E. coli cells producing the ribonuclease toxin MazF.
December 25, 2023 at 10:59 AM
1/5
Can random sequences encode meaningful functions and allow de novo gene birth? To explore this, Michael Laub and I screened 100 million random genes, without sequence similarity to natural genes, for their ability to rescue growth arrest of E. coli cells producing the ribonuclease toxin MazF.
Can random sequences encode meaningful functions and allow de novo gene birth? To explore this, Michael Laub and I screened 100 million random genes, without sequence similarity to natural genes, for their ability to rescue growth arrest of E. coli cells producing the ribonuclease toxin MazF.
Reposted by idanfrumkin.bsky.social
Fascinating paper on making new genes from random sequences!
Idan Frumkin & Michael Laub. Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein homeostasis pathways.
doi.org/10.1038/s415...
#Microsky #Genetics #Evolution #Microbiology
Idan Frumkin & Michael Laub. Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein homeostasis pathways.
doi.org/10.1038/s415...
#Microsky #Genetics #Evolution #Microbiology
Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein home...
Screening 100 million random genes, which lack homology to natural sequences, for their ability to rescue growth arrest of Escherichia coli cells caused by the toxin MazF, the authors find ~2,000 hi...
doi.org
December 4, 2023 at 4:21 PM
Fascinating paper on making new genes from random sequences!
Idan Frumkin & Michael Laub. Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein homeostasis pathways.
doi.org/10.1038/s415...
#Microsky #Genetics #Evolution #Microbiology
Idan Frumkin & Michael Laub. Selection of a de novo gene that can promote survival of Escherichia coli by modulating protein homeostasis pathways.
doi.org/10.1038/s415...
#Microsky #Genetics #Evolution #Microbiology