Iakovos Lazaridis
@iaklaz.bsky.social
McGovern Institute for Brain Research, MIT
Pinned
Iakovos Lazaridis
@iaklaz.bsky.social
· Dec 8
Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits
Lazaridis et al. delineate a previously unrecognized pair of striosomal direct D1 and indirect D2 circuits that target substantia nigra dopamine-containing neurons, controllers of mood, action, and reinforcement learning. These striosomal circuits have effects opposing those of the canonical D1-direct/D2-indirect pathways, likely modulating them.
www.cell.com
Check also our recent paper in Current Biology on how striosomes regulate dopamine in the dorsal striatum via dual pathways that parallel canonical basal ganglia circuits.
www.cell.com/current-biol...
mcgovern.mit.edu/2024/10/23/b...
www.cell.com/current-biol...
mcgovern.mit.edu/2024/10/23/b...
Reposted by Iakovos Lazaridis
(first post in this platform) happy to share our new paper on visual-based center-surround interactions in the superior colliculus, showcasing a general approach to dissect local circuit computations. @NeuroAlc
#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA
October 22, 2025 at 8:16 PM
(first post in this platform) happy to share our new paper on visual-based center-surround interactions in the superior colliculus, showcasing a general approach to dissect local circuit computations. @NeuroAlc
Reposted by Iakovos Lazaridis
#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA
October 17, 2025 at 1:06 PM
#Visual #salience generation involves center-surround dynamics, but what performs these computations? This study shows that the #SuperiorColliculus encodes center-surround dynamics under isolated conditions, and provides insights into the circuit implementation @plosbiology.org 🧪 plos.io/4n7RpsA
Reposted by Iakovos Lazaridis
Save the date and join us for a webinar about cholinergic interneurons, hosted by the Swedish Basal Ganglia Society. We are excited to have two distinguished speakers: Stephanie Cragg and Mark Howe. Everyone is welcome and no registration is required! swebags.ebrains.se/events/choli...
March 18, 2025 at 2:52 PM
Save the date and join us for a webinar about cholinergic interneurons, hosted by the Swedish Basal Ganglia Society. We are excited to have two distinguished speakers: Stephanie Cragg and Mark Howe. Everyone is welcome and no registration is required! swebags.ebrains.se/events/choli...
Reposted by Iakovos Lazaridis
The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control
The two novel pathways control dopamine release in opposing ways and may link motivation and mood to action, a new study shows.
www.thetransmitter.org
January 24, 2025 at 3:04 PM
The ‘go’ and ‘no-go’ pathways in the basal ganglia are not the only pathways that control movement, as a new study reveals two additional circuits that modulate dopamine and movement.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/basal-gangli...
Reposted by Iakovos Lazaridis
first thing to share here!
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
Progressive degeneration of dopamine neurons (DANs) defines Parkinson's disease (PD). However, the identity and function of the most vulnerable DAN populations in prodromal PD remain undefined. Here, ...
www.biorxiv.org
December 22, 2024 at 10:43 PM
first thing to share here!
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
excited to share lab’s first study in Parkinson’s disease revealing the prodromal vulnerability and function of the dopamine neuron subtype defined by Anxa1 expression - a specialized system controlling procedural motor learning
www.biorxiv.org/content/10.1...
Interested in dopamine regulation? Don’t forget the astrocytes! We’re excited to share our new preprint on astrocyte-dopamine interactions in the dorsal striatum and behavioral state transitions. @biorxiv_neursci, @mcgovernmit, @AnnMGraybiel
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
December 8, 2024 at 4:02 PM
Interested in dopamine regulation? Don’t forget the astrocytes! We’re excited to share our new preprint on astrocyte-dopamine interactions in the dorsal striatum and behavioral state transitions. @biorxiv_neursci, @mcgovernmit, @AnnMGraybiel
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Reposted by Iakovos Lazaridis
Can there be a “little brain” in the heart?
This is one of the “out of the box” project that we performed as KizilLab and
AmpatzisLab. Huge thanks to Andrea, Kostas and Caghan 🤘🏻
#zebrafish #heart #neuron
Check this little brain of the heart:
www.nature.com/articles/s41...
This is one of the “out of the box” project that we performed as KizilLab and
AmpatzisLab. Huge thanks to Andrea, Kostas and Caghan 🤘🏻
#zebrafish #heart #neuron
Check this little brain of the heart:
www.nature.com/articles/s41...
Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system - Nature Communications
Although the heart has its own nervous system, its organization and functionality remain largely unknown. Here, the authors reveal the molecular, chemical, and functional diversity of neurons within t...
www.nature.com
December 4, 2024 at 4:02 PM
Can there be a “little brain” in the heart?
This is one of the “out of the box” project that we performed as KizilLab and
AmpatzisLab. Huge thanks to Andrea, Kostas and Caghan 🤘🏻
#zebrafish #heart #neuron
Check this little brain of the heart:
www.nature.com/articles/s41...
This is one of the “out of the box” project that we performed as KizilLab and
AmpatzisLab. Huge thanks to Andrea, Kostas and Caghan 🤘🏻
#zebrafish #heart #neuron
Check this little brain of the heart:
www.nature.com/articles/s41...
Reposted by Iakovos Lazaridis
A Prefrontal Cortex Map based on Single Neuron Activity https://www.biorxiv.org/content/10.1101/2024.11.06.622308v1
A Prefrontal Cortex Map based on Single Neuron Activity https://www.biorxiv.org/content/10.1101/2024.11.06.622308v1
The intrinsic organization underlying the central cognitive role of the prefrontal cortex (PFC) is p
www.biorxiv.org
November 7, 2024 at 10:16 AM
A Prefrontal Cortex Map based on Single Neuron Activity https://www.biorxiv.org/content/10.1101/2024.11.06.622308v1