Holly Gildea
@hollygildea.bsky.social
Postdoc in Liddelow lab studying astrocyte contributions to aging related disease
Reposted by Holly Gildea
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
November 10, 2025 at 4:43 PM
@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below.
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social.
(1/2)
Reposted by Holly Gildea
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
October 24, 2025 at 4:32 PM
I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...
🧵 Highlights below!
Reposted by Holly Gildea
🚨Please share! We are hiring a post-doc! 🪱 🐀
Job posting: www.training.nih.gov/jobs/pdf-gb-...
Lab Website: www.niddk.nih.gov/research-fun...
NIH Trainee info: www.training.nih.gov
Job posting: www.training.nih.gov/jobs/pdf-gb-...
Lab Website: www.niddk.nih.gov/research-fun...
NIH Trainee info: www.training.nih.gov
September 24, 2025 at 7:25 PM
🚨Please share! We are hiring a post-doc! 🪱 🐀
Job posting: www.training.nih.gov/jobs/pdf-gb-...
Lab Website: www.niddk.nih.gov/research-fun...
NIH Trainee info: www.training.nih.gov
Job posting: www.training.nih.gov/jobs/pdf-gb-...
Lab Website: www.niddk.nih.gov/research-fun...
NIH Trainee info: www.training.nih.gov
Some of the coolest work I’ve ever been a (small) part of from @melcooperphd.bsky.social - it is a joy to be “in network” with you!
Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1
July 22, 2025 at 8:18 PM
Some of the coolest work I’ve ever been a (small) part of from @melcooperphd.bsky.social - it is a joy to be “in network” with you!
Reposted by Holly Gildea
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains
is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets
and lose their phagocytic cap...
www.cell.com
May 19, 2025 at 6:14 PM
Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...
Our new work on astrocyte responses in glaucoma is out today! A tour de force of tissue clearing and analysis by @melcooperphd.bsky.social. It's one of those stories that leads to even more great questions, so stay tuned!
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
urldefense.com
March 10, 2025 at 7:43 PM
Our new work on astrocyte responses in glaucoma is out today! A tour de force of tissue clearing and analysis by @melcooperphd.bsky.social. It's one of those stories that leads to even more great questions, so stay tuned!
Reposted by Holly Gildea
Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...
Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates
Hasel et al. show that molecularly and morphologically specialized astrocytes make
up the brain and spinal cord surface, thereby creating the glia limitans superficialis.
These astrocytes selectively ...
www.cell.com
February 24, 2025 at 10:44 AM
Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...
Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social
Mechanisms of astrocyte aging in reactivity and disease - Molecular Neurodegeneration
Normal aging alters brain functions and phenotypes. However, it is not well understood how astrocytes are impacted by aging, nor how they contribute to neuronal dysfunction and disease risk as organis...
molecularneurodegeneration.biomedcentral.com
February 21, 2025 at 12:08 PM
Excited to share our review on astrocyte aging, out today! Hopefully the only Friday surprises this week are Liddelow lab publications! 🧪 #neuroskyence @liddelowsa.bsky.social
Reposted by Holly Gildea
The average person with the flu gives it to around 1.4 people. The average person with measles gives it to between 12 and 18 people.
Measles cases continue to surge globally, putting millions of children at risk.
More than 10 million people globally were infected with measles in 2023, a 20% increase from the previous year.
bit.ly/48SAtkf
More than 10 million people globally were infected with measles in 2023, a 20% increase from the previous year.
bit.ly/48SAtkf
February 17, 2025 at 1:36 PM
The average person with the flu gives it to around 1.4 people. The average person with measles gives it to between 12 and 18 people.
When I said “science is over we can all go home” it was a JOKE! I was KIDDING! 😭😭😭😭
February 8, 2025 at 12:19 AM
When I said “science is over we can all go home” it was a JOKE! I was KIDDING! 😭😭😭😭
Contact your representatives using this link! An easy way to take action
February 6, 2025 at 7:20 PM
Contact your representatives using this link! An easy way to take action
Reposted by Holly Gildea
Happy #BlackHistoryMonth! ✨
They’ll never be able to take away the impact and contributions of Black scientists, no matter how hard they try.
So each week this month, I’ll be highlighting a few #BlackInNeuro scientists for you to learn about, celebrate their work, & follow 👩🏾🔬👨🏽🔬
They’ll never be able to take away the impact and contributions of Black scientists, no matter how hard they try.
So each week this month, I’ll be highlighting a few #BlackInNeuro scientists for you to learn about, celebrate their work, & follow 👩🏾🔬👨🏽🔬
February 2, 2025 at 3:09 PM
Happy #BlackHistoryMonth! ✨
They’ll never be able to take away the impact and contributions of Black scientists, no matter how hard they try.
So each week this month, I’ll be highlighting a few #BlackInNeuro scientists for you to learn about, celebrate their work, & follow 👩🏾🔬👨🏽🔬
They’ll never be able to take away the impact and contributions of Black scientists, no matter how hard they try.
So each week this month, I’ll be highlighting a few #BlackInNeuro scientists for you to learn about, celebrate their work, & follow 👩🏾🔬👨🏽🔬
I was a public school free lunch kid in a SNAP family who went to college on Pell grants & work study. My graduate education was funded by an NIH T32, the NSF GRFP, and an NIH F99, the K00 portion of which still funds me as a postdoc! I quite literally would not be here without federal funding.
January 29, 2025 at 1:02 PM
I was a public school free lunch kid in a SNAP family who went to college on Pell grants & work study. My graduate education was funded by an NIH T32, the NSF GRFP, and an NIH F99, the K00 portion of which still funds me as a postdoc! I quite literally would not be here without federal funding.
Reposted by Holly Gildea
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
January 28, 2025 at 9:45 PM
If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me.
Please amplify. If you are also able to host fly strains, add your name as well.
Please amplify. If you are also able to host fly strains, add your name as well.
Reposted by Holly Gildea
Are you a scientist or science policy expert who's feeling a little nervous about federal research funding, as the next administration prepared to take over? I want to hear from you.
[reposting would be greatly appreciated!]
#neuroskyence #medsky #academicsky
[reposting would be greatly appreciated!]
#neuroskyence #medsky #academicsky
January 7, 2025 at 10:36 PM
Are you a scientist or science policy expert who's feeling a little nervous about federal research funding, as the next administration prepared to take over? I want to hear from you.
[reposting would be greatly appreciated!]
#neuroskyence #medsky #academicsky
[reposting would be greatly appreciated!]
#neuroskyence #medsky #academicsky
Highly recommend submitting session ideas for SfN 2025! I had an excellent time chairing a minisymposium this past year, and it was both a great opportunity and a perfect way to hear all of the talks I personally wanted to hear! Deadline for this year is Jan 22 @sfn.org
Neuroscience 2025
www.sfn.org
January 8, 2025 at 3:31 PM
Highly recommend submitting session ideas for SfN 2025! I had an excellent time chairing a minisymposium this past year, and it was both a great opportunity and a perfect way to hear all of the talks I personally wanted to hear! Deadline for this year is Jan 22 @sfn.org
Reposted by Holly Gildea
Worm people: We are looking for a postdoc to join the C. elegans Mentor Match committee.
This is a great opportunity to shape a global mentorship program and gain leadership experience.
📩 DM or email me and Andrea Calixto if interested—and please spread the word! 🙌
This is a great opportunity to shape a global mentorship program and gain leadership experience.
📩 DM or email me and Andrea Calixto if interested—and please spread the word! 🙌
January 6, 2025 at 4:56 PM
Worm people: We are looking for a postdoc to join the C. elegans Mentor Match committee.
This is a great opportunity to shape a global mentorship program and gain leadership experience.
📩 DM or email me and Andrea Calixto if interested—and please spread the word! 🙌
This is a great opportunity to shape a global mentorship program and gain leadership experience.
📩 DM or email me and Andrea Calixto if interested—and please spread the word! 🙌
Receiving high-quality, attentive, productive feedback from reviewers: 🤩😍🥳
Actually incorporating said feedback: 😭
Actually incorporating said feedback: 😭
January 2, 2025 at 9:38 PM
Receiving high-quality, attentive, productive feedback from reviewers: 🤩😍🥳
Actually incorporating said feedback: 😭
Actually incorporating said feedback: 😭
Congrats to Cory Pender of @dillinlab.bsky.social for this work out today! The mechanism ended up being both super cool and unexpected, and it was a joy to be involved with!
Perception of a pathogenic signature initiates intergenerational protection
Transmission of immune responses from one generation to the next represents a powerful adaptive mechanism to protect an organism’s descendants. Parent…
www.sciencedirect.com
December 25, 2024 at 1:57 AM
Congrats to Cory Pender of @dillinlab.bsky.social for this work out today! The mechanism ended up being both super cool and unexpected, and it was a joy to be involved with!
Reposted by Holly Gildea
Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
Lipids: Emerging Players of Microglial Biology
Lipids are crucial in mediating microglial metabolism and function. The microglial lipidome is vast and complex, with over 10,000 lipid species. We discuss key lipid classes and their roles in m...
onlinelibrary.wiley.com
December 17, 2024 at 2:46 PM
Happy to share our review on how different lipids shape microglial biology in #GLIA journal. 💫 onlinelibrary.wiley.com/doi/full/10....
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
👉🏽with Gaurav Chopra, Caitlin Randolph, and @katherinewalker.bsky.social
Very glad that everyone finally made the switch from the bird site so that I can finally find important papers I desperately need to read while procrastinating again!
November 26, 2024 at 7:41 PM
Very glad that everyone finally made the switch from the bird site so that I can finally find important papers I desperately need to read while procrastinating again!
Reposted by Holly Gildea
immense respect to this science teacher for seeing his opportunity and grabbing onto it with both hands
January 9, 2024 at 3:08 AM
immense respect to this science teacher for seeing his opportunity and grabbing onto it with both hands
I thought this would go without saying but perhaps don't use different quality control standards for different conditions that you are directly comparing 🫠
December 19, 2023 at 9:42 PM
I thought this would go without saying but perhaps don't use different quality control standards for different conditions that you are directly comparing 🫠