Melissa Harrison Lab
@harrisonflylab.bsky.social
How transcription is regulated to drive development
https://harrisonlab.bmolchem.wisc.edu
https://harrisonlab.bmolchem.wisc.edu
Proud of the lab for helping teach kids and adults about Drosophila research and the importance of funding foundational science at the Wisconsin Science Festival today. Couldn't ask for a more engaged and enthusiastic group.
October 22, 2025 at 7:14 PM
Proud of the lab for helping teach kids and adults about Drosophila research and the importance of funding foundational science at the Wisconsin Science Festival today. Couldn't ask for a more engaged and enthusiastic group.
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August 29, 2025 at 9:25 PM
A vital resource. Please support.
Reposted by Melissa Harrison Lab
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 23, 2025 at 11:38 PM
We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Melissa Harrison Lab
Check our latest with Yacine Kherdjemil and @eileen-furlong.bsky.social and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression. www.cell.com/molecular-ce...
Chip (Ldb1) is a putative cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation
Chip/Ldb1 is a crucial cofactor regulating enhancer function and chromatin interactions.
Using optogenetics, Galouzis, Kherdjemil et al. show that Chip is only essential during
zygotic genome activati...
www.cell.com
June 10, 2025 at 7:49 AM
Check our latest with Yacine Kherdjemil and @eileen-furlong.bsky.social and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression. www.cell.com/molecular-ce...
Reposted by Melissa Harrison Lab
