Santhosh Girirajan
@girirajan.bsky.social
T. Ming Chu Professor and Department Head of Biochemistry and Molecular Biology at Penn State University.
Human geneticist studying genetic interactions in complex disorders
Human geneticist studying genetic interactions in complex disorders
Reposted by Santhosh Girirajan
Understanding the molecular diversity of synapses www.nature.com/articles/s41... - molecular diversity = functional diversity!
Understanding the molecular diversity of synapses - Nature Reviews Neuroscience
The set of proteins present at synapses determines their heterogeneous functions and properties. In this Review, van Oostrum and Schuman describe the molecular mechanisms that contribute to the d...
www.nature.com
December 10, 2024 at 9:08 AM
Understanding the molecular diversity of synapses www.nature.com/articles/s41... - molecular diversity = functional diversity!
Reposted by Santhosh Girirajan
What a wonderful podcast interview of Shai Shaham by @stevenstrogatz.com!
I love how Shai made the case for basic science: I think science has proven over and over how discoveries that seemed unimportant and fringe at any moment turn out to be all the rage just a couple of decades later.
#Celegans
I love how Shai made the case for basic science: I think science has proven over and over how discoveries that seemed unimportant and fringe at any moment turn out to be all the rage just a couple of decades later.
#Celegans
How Is Cell Death Essential to Life? | Quanta Magazine
Cells in our bodies are constantly dying — and these countless tiny deaths are essential to human health and multicellular life itself. In this episode, co-host Steven Strogatz speaks with cellular bi...
www.quantamagazine.org
December 10, 2024 at 2:59 PM
What a wonderful podcast interview of Shai Shaham by @stevenstrogatz.com!
I love how Shai made the case for basic science: I think science has proven over and over how discoveries that seemed unimportant and fringe at any moment turn out to be all the rage just a couple of decades later.
#Celegans
I love how Shai made the case for basic science: I think science has proven over and over how discoveries that seemed unimportant and fringe at any moment turn out to be all the rage just a couple of decades later.
#Celegans
Reposted by Santhosh Girirajan
I occasionally did little threads over at The Other Place on papers in biology that seem only to make biology sound even more complicated and arbitrary but in fact illustrate some important generic principles. So here's one.
This is the paper I’m looking at. 1/n
www.science.org/doi/10.1126/...
This is the paper I’m looking at. 1/n
www.science.org/doi/10.1126/...
A microRNA is the effector gene of a classic evolutionary hotspot locus
In Lepidoptera (butterflies and moths), the genomic region around the gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 mi...
www.science.org
December 10, 2024 at 12:24 PM
I occasionally did little threads over at The Other Place on papers in biology that seem only to make biology sound even more complicated and arbitrary but in fact illustrate some important generic principles. So here's one.
This is the paper I’m looking at. 1/n
www.science.org/doi/10.1126/...
This is the paper I’m looking at. 1/n
www.science.org/doi/10.1126/...
Reposted by Santhosh Girirajan
This fearless science sleuth risked her career to expose publication fraud
Anna Abalkina @abalkina.bsky.social is part of Nature’s 10, a list of people who shaped science in 2024.
Holly Else reports at Nature.
www.nature.com/articles/d41...
Anna Abalkina @abalkina.bsky.social is part of Nature’s 10, a list of people who shaped science in 2024.
Holly Else reports at Nature.
www.nature.com/articles/d41...
This fearless science sleuth risked her career to expose publication fraud
Anna Abalkina is part of Nature’s 10, a list of people who shaped science in 2024.
www.nature.com
December 10, 2024 at 7:51 AM
This fearless science sleuth risked her career to expose publication fraud
Anna Abalkina @abalkina.bsky.social is part of Nature’s 10, a list of people who shaped science in 2024.
Holly Else reports at Nature.
www.nature.com/articles/d41...
Anna Abalkina @abalkina.bsky.social is part of Nature’s 10, a list of people who shaped science in 2024.
Holly Else reports at Nature.
www.nature.com/articles/d41...
Reposted by Santhosh Girirajan
Great story about mentorship, privilege, serendipity and more! 🧪
Bluetorial: Mentors II: The new assistant professor and my undergraduate years
a cartoon says hey everybody an old man 's talking while bart simpson looks on
ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on
media.tenor.com
December 8, 2024 at 2:13 PM
Great story about mentorship, privilege, serendipity and more! 🧪
Reposted by Santhosh Girirajan
Very excited about this work and the potential applications of of cell-free RNA.
Today was a great day! Our paper on using an AI platform for cell-free RNA liquid biopsy is finally published in Nature Communications! Huge thanks to our amazing team at @exai.bio for making this happen! The code is open-source and readily available.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer - Nature Communications
A generative AI model, Orion, learns a robust and generalizable pattern of non-small cell lung cancer from cancer-specific circulating non-coding RNAs. Orion enhances the performance of liquid biopsy ...
www.nature.com
November 22, 2024 at 3:27 AM
Very excited about this work and the potential applications of of cell-free RNA.
Reposted by Santhosh Girirajan
We learn in school about the distinctive shapes of each of our body’s organs, but how did that arise? Organs self-assemble, as individual cells change shape and move in coordinated ways, sometimes with multiple cell /tissue types shaping one another 1/n 🧪
December 1, 2024 at 1:36 PM
We learn in school about the distinctive shapes of each of our body’s organs, but how did that arise? Organs self-assemble, as individual cells change shape and move in coordinated ways, sometimes with multiple cell /tissue types shaping one another 1/n 🧪
Please check our publications posted recently:
Cross-ancestry analysis identifies genes associated with obesity risk and protection www.medrxiv.org/content/10.1...
Genetic modifiers and ascertainment drive variable expressivity of complex disorders
www.medrxiv.org/content/10.1...
Cross-ancestry analysis identifies genes associated with obesity risk and protection www.medrxiv.org/content/10.1...
Genetic modifiers and ascertainment drive variable expressivity of complex disorders
www.medrxiv.org/content/10.1...
Cross-ancestry analysis identifies genes associated with obesity risk and protection
Gene discoveries in obesity have largely been based on European cohorts, leading to an ancestral bias, that limits their generalizability across populations. We performed a gene-based rare variant ass...
www.medrxiv.org
November 14, 2024 at 12:26 AM
Please check our publications posted recently:
Cross-ancestry analysis identifies genes associated with obesity risk and protection www.medrxiv.org/content/10.1...
Genetic modifiers and ascertainment drive variable expressivity of complex disorders
www.medrxiv.org/content/10.1...
Cross-ancestry analysis identifies genes associated with obesity risk and protection www.medrxiv.org/content/10.1...
Genetic modifiers and ascertainment drive variable expressivity of complex disorders
www.medrxiv.org/content/10.1...