fighumphlab
@fighumph.bsky.social
🇮🇪 Immunologist, Assistant Prof. @UMassChan
Innate Immunity, cell death, immunometabolism and beyond.
umassmed.edu/humphries-lab
Innate Immunity, cell death, immunometabolism and beyond.
umassmed.edu/humphries-lab
thanks to @mbio.bsky.social for the invitation to write this review on Interferons in human monogenic diseases. Written with two superstar @umassgrad.bsky.social students Laurel Stine and Sara Cahill. @umasschan.bsky.social @umassmedicine.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Interferons in human inborn errors of disease | mBio
Interferons (IFNs) are a family of pleiotropic cytokines traditionally associated
with anti-viral and anti-tumor immunities (1). IFNs are ubiquitously produced in response to infection, damage, or cel...
journals.asm.org
July 3, 2025 at 3:09 PM
thanks to @mbio.bsky.social for the invitation to write this review on Interferons in human monogenic diseases. Written with two superstar @umassgrad.bsky.social students Laurel Stine and Sara Cahill. @umasschan.bsky.social @umassmedicine.bsky.social
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by fighumphlab
In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...
Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology
In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...
www.nature.com
April 28, 2025 at 3:49 PM
In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...
New review from my lab out today in @cp-trendsimmuno.bsky.social we discuss in born errors in human inflammasomes and disease signatures beyond IL-1. @umasschan.bsky.social @umassmedicine.bsky.social
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Inflammasomopathies: mechanisms and disease signatures
Inflammasomes form in response to infection, cellular stress, or damage. Gain-of-function
(GOF) mutations in inflammasome receptors have been identified as the underlying cause
of severe inflammatory ...
www.cell.com
April 23, 2025 at 7:30 AM
New review from my lab out today in @cp-trendsimmuno.bsky.social we discuss in born errors in human inflammasomes and disease signatures beyond IL-1. @umasschan.bsky.social @umassmedicine.bsky.social
www.cell.com/trends/immun...
www.cell.com/trends/immun...
Reposted by fighumphlab
Review @cp-trendsimmuno.bsky.social
Inflammasomopathies: mechanisms and disease signatures
www.cell.com/trends/immun...
Inflammasomopathies: mechanisms and disease signatures
www.cell.com/trends/immun...
April 22, 2025 at 3:14 PM
Review @cp-trendsimmuno.bsky.social
Inflammasomopathies: mechanisms and disease signatures
www.cell.com/trends/immun...
Inflammasomopathies: mechanisms and disease signatures
www.cell.com/trends/immun...
Reposted by fighumphlab
MARCO is an IFN-restricted immunometabolic decoy LPS receptor
doi.org/10.1101/2025...
doi.org/10.1101/2025...
March 17, 2025 at 6:46 PM
MARCO is an IFN-restricted immunometabolic decoy LPS receptor
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Sharing my labs first pre-print ! We discovered a remarkable innate checkpoint in macrophages ! Congrats to tall the authors @umassmedicine.bsky.social @umasschan.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
MARCO is an IFN-restricted immunometabolic decoy LPS receptor
Intracellular sensing of lipopolysaccharide is an essential component of pathogen detection that governs the innate immune response. However, how this process is controlled to maintain homeostasis and...
www.biorxiv.org
March 17, 2025 at 4:08 PM
Sharing my labs first pre-print ! We discovered a remarkable innate checkpoint in macrophages ! Congrats to tall the authors @umassmedicine.bsky.social @umasschan.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...