Pukkila-Worley Lab
@rpwlab.bsky.social
Research Scientist. Infectious Diseases Physician. Professor of Medicine. UMass Chan Medical School. Innate immunity, intestinal epithelial cells and worms.
Pinned
Pukkila-Worley Lab
@rpwlab.bsky.social
· Apr 28
Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology
In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...
www.nature.com
In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...
Check out the cover of @cp-trendsimmuno.bsky.social !! Art by lab alumna Sammy Tse, highlighting our lab's review in the issue by Khursheed Wani on enzymatic TIR proteins in innate immunity!!! www.cell.com/trends/immun...
June 12, 2025 at 4:27 PM
Check out the cover of @cp-trendsimmuno.bsky.social !! Art by lab alumna Sammy Tse, highlighting our lab's review in the issue by Khursheed Wani on enzymatic TIR proteins in innate immunity!!! www.cell.com/trends/immun...
Incredibly proud of Mo Nasrallah @umasschan.bsky.social MD,PhD graduate from my lab. So much fun to celebrate his accomplishments and those of his classmates this weekend. #UMassChan2025
June 2, 2025 at 10:59 AM
Incredibly proud of Mo Nasrallah @umasschan.bsky.social MD,PhD graduate from my lab. So much fun to celebrate his accomplishments and those of his classmates this weekend. #UMassChan2025
Excited to share another review from the lab, this one by @khursheed01.bsky.social, out this week in
@cp-trendsimmuno.bsky.social . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! www.cell.com/trends/immun...
@cp-trendsimmuno.bsky.social . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! www.cell.com/trends/immun...
Evolutionarily ancient functions of enzymatic TIR proteins in innate immunity
Proteins with a Toll/interleukin-1 receptor/resistance (TIR) domain are among the
most ancient immune regulators and include well-known pattern recognition receptors
(PRRs). A specialized subset of TI...
www.cell.com
May 21, 2025 at 5:47 PM
Excited to share another review from the lab, this one by @khursheed01.bsky.social, out this week in
@cp-trendsimmuno.bsky.social . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! www.cell.com/trends/immun...
@cp-trendsimmuno.bsky.social . Join us for a fun tour of what we think are the coolest proteins in all of innate immunity! www.cell.com/trends/immun...
In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...
Patterns of pathogenesis in innate immunity: insights from C. elegans - Nature Reviews Immunology
In this Review, Tse-Kang, Wani and Pukkila-Worley discuss how nematodes, such as Caenorhabditis elegans, rely on ‘patterns of pathogenesis’ as opposed to the sensing of specific ligands by pattern-rec...
www.nature.com
April 28, 2025 at 3:49 PM
In my first bsky post, I am excited to share our recent review out in @natrevimmunol.bsky.social. We discuss mechanisms that identify patterns of pathogenesis -- specific ligands or symptoms in the host that indicate active infection with an infectious microorganism. www.nature.com/articles/s41...