Fiamma Salerno
@fiammasalerno.bsky.social
Molecular Immunologist || T & B cell enthusiast || RNA-binding protein lover
Tenure-track group leader @LUMC Leiden
Tenure-track group leader @LUMC Leiden
Reposted by Fiamma Salerno
Germinal center B cells rely on ZFP36L1 and ZFP36L2 to control cell division and avoid replication stress that leads to apoptosis @sciimmunology.bsky.social @martint-babraham.bsky.social
www.science.org/doi/10.1126/...
@babrahaminst.bsky.social
www.science.org/doi/10.1126/...
@babrahaminst.bsky.social
October 31, 2025 at 8:50 PM
Germinal center B cells rely on ZFP36L1 and ZFP36L2 to control cell division and avoid replication stress that leads to apoptosis @sciimmunology.bsky.social @martint-babraham.bsky.social
www.science.org/doi/10.1126/...
@babrahaminst.bsky.social
www.science.org/doi/10.1126/...
@babrahaminst.bsky.social
special thanks to all my collaborators! in particular to my former supervisor @martint-babraham.bsky.social
November 3, 2025 at 8:51 AM
special thanks to all my collaborators! in particular to my former supervisor @martint-babraham.bsky.social
🚨 New paper alert!!
RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells.
A new mechanism showing how post-transcriptional control keeps our immune cells in check!
#RNA #Bcells #GenomeStability
www.science.org/doi/10.1126/...
RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells.
A new mechanism showing how post-transcriptional control keeps our immune cells in check!
#RNA #Bcells #GenomeStability
www.science.org/doi/10.1126/...
RNA binding proteins control the G2-M checkpoint of the germinal center B cell
Germinal center B cells rely on ZFP36L1 and ZFP36L2 to control cell division and avoid replication stress that leads to apoptosis.
www.science.org
November 3, 2025 at 8:46 AM
🚨 New paper alert!!
RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells.
A new mechanism showing how post-transcriptional control keeps our immune cells in check!
#RNA #Bcells #GenomeStability
www.science.org/doi/10.1126/...
RNA-binding proteins ZFP36L1 & ZFP36L2 act as guardians of genome stability in fast-dividing germinal center B cells.
A new mechanism showing how post-transcriptional control keeps our immune cells in check!
#RNA #Bcells #GenomeStability
www.science.org/doi/10.1126/...
This is great!
Exciting news for the RNA research community!
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130...
#RNA #bioinformatics #RNAstructure #modomics
Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology
The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...
genomebiology.biomedcentral.com
October 27, 2025 at 8:43 AM
This is great!
I am deeply honored and humbled to receive the 2025 KNAW Early Career Award from the Royal Netherlands Academy of Arts and Sciences! 🌟
This recognition means a lot, especially as a scientist working on fundamental immunology. Grateful to everyone who has supported and inspired me along the way! 🙏🏼
This recognition means a lot, especially as a scientist working on fundamental immunology. Grateful to everyone who has supported and inspired me along the way! 🙏🏼
October 16, 2025 at 10:18 AM
I am deeply honored and humbled to receive the 2025 KNAW Early Career Award from the Royal Netherlands Academy of Arts and Sciences! 🌟
This recognition means a lot, especially as a scientist working on fundamental immunology. Grateful to everyone who has supported and inspired me along the way! 🙏🏼
This recognition means a lot, especially as a scientist working on fundamental immunology. Grateful to everyone who has supported and inspired me along the way! 🙏🏼
Happy to share the first pre-print of the lab! 📢
💡Do you want to know how CD4 T cells decide their fate?
We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation.
www.biorxiv.org/content/10.1...
💡Do you want to know how CD4 T cells decide their fate?
We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation.
www.biorxiv.org/content/10.1...
Requirements for development of T-helper1 and T-follicular helper cells from a common precursor
Activated CD4 T cells become either T-helper (Th) or T-follicular helper (Tfh) cells that support cellular or humoral immunity. We have investigated how polyclonal, vaccine induced T cells in mice bif...
www.biorxiv.org
September 14, 2025 at 6:11 PM
Happy to share the first pre-print of the lab! 📢
💡Do you want to know how CD4 T cells decide their fate?
We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation.
www.biorxiv.org/content/10.1...
💡Do you want to know how CD4 T cells decide their fate?
We used a mouse vaccination model to trace endogenous polyclonal CD4 T cells on their journey towards Th1 or Tfh differentiation.
www.biorxiv.org/content/10.1...
Reposted by Fiamma Salerno
@biorxivpreprint.bsky.social Requirements for development of T-helper1 and T-follicular helper cells from a common precursor @unileiden.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 14, 2025 at 5:20 PM
@biorxivpreprint.bsky.social Requirements for development of T-helper1 and T-follicular helper cells from a common precursor @unileiden.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fiamma Salerno
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology
Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...
www.nature.com
September 12, 2025 at 2:20 AM
Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social
Thread below...
Reposted by Fiamma Salerno
it is finally out! 👇 our #ML pipeline SONAR, which can predict the protein abundance in #immune cells. Using sequence features present in the #RNA. With @bnicolet.bsky.social
Supported by the @erc.europa.eu and@oncodeinstitute.bsky.social
www.science.org/doi/epdf/10....
Supported by the @erc.europa.eu and@oncodeinstitute.bsky.social
www.science.org/doi/epdf/10....
Learning the sequence code of protein expression in human immune cells
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www.science.org
July 23, 2025 at 7:07 PM
it is finally out! 👇 our #ML pipeline SONAR, which can predict the protein abundance in #immune cells. Using sequence features present in the #RNA. With @bnicolet.bsky.social
Supported by the @erc.europa.eu and@oncodeinstitute.bsky.social
www.science.org/doi/epdf/10....
Supported by the @erc.europa.eu and@oncodeinstitute.bsky.social
www.science.org/doi/epdf/10....
Many congratulations Kaspar, this is amazing news!! 🎉
July 31, 2025 at 7:16 AM
Many congratulations Kaspar, this is amazing news!! 🎉
Congratulations to you all! It's a pleasure to see this beautiful work online 🎉
ZFP36-family of RNA-binding proteins enables Treg cells to enforce immune homeostasis.
www.nature.com/articles/s41...
ZFP36-family of RNA-binding proteins enables Treg cells to enforce immune homeostasis.
www.nature.com/articles/s41...
May 7, 2025 at 7:43 PM
Congratulations to you all! It's a pleasure to see this beautiful work online 🎉
ZFP36-family of RNA-binding proteins enables Treg cells to enforce immune homeostasis.
www.nature.com/articles/s41...
ZFP36-family of RNA-binding proteins enables Treg cells to enforce immune homeostasis.
www.nature.com/articles/s41...
We celebrate the first birthday of the lab! 🎂 Stay tuned for the great science we have in the pipeline 🎉
April 3, 2025 at 6:06 AM
We celebrate the first birthday of the lab! 🎂 Stay tuned for the great science we have in the pipeline 🎉
Reposted by Fiamma Salerno
Amazing stuff from @marvintanenbaum.bsky.social!
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
#RNAsky #RNABiology
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
#RNAsky #RNABiology
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 1, 2025 at 6:57 AM
Amazing stuff from @marvintanenbaum.bsky.social!
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
#RNAsky #RNABiology
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
#RNAsky #RNABiology
Congratulations! Looking forward to reading the paper 😊
January 11, 2025 at 7:52 AM
Congratulations! Looking forward to reading the paper 😊
I would love to be added. Thanks for organising this!
January 5, 2025 at 11:59 AM
I would love to be added. Thanks for organising this!