Doug Epstein
@epsteind.bsky.social
Professor of Genetics, Perelman School of Medicine, University of Pennsylvania
hearing loss, brain development, gene regulation
hearing loss, brain development, gene regulation
Penn Genetics is excited to host Harmit Malik who will be giving the Bernard Cohen Memorial Lecture today.
May 20, 2025 at 2:12 PM
Penn Genetics is excited to host Harmit Malik who will be giving the Bernard Cohen Memorial Lecture today.
Reposted by Doug Epstein
Jehuda Lindenblatt wanted the writer Taffy Brodesser-Akner to tell his story of survival for years. In finally doing so, she reckons with how many people in her generation push away thoughts of the Holocaust to cope, only to find themselves dealing with them anyway.
The Holocaust Story I Said I Wouldn’t Write
For years, my friend’s father asked me to recount his childhood escape from the Nazis. Why did it take me this long?
nyti.ms
April 6, 2025 at 8:40 PM
Jehuda Lindenblatt wanted the writer Taffy Brodesser-Akner to tell his story of survival for years. In finally doing so, she reckons with how many people in her generation push away thoughts of the Holocaust to cope, only to find themselves dealing with them anyway.
Reposted by Doug Epstein
Breaking News: Mark Carney, a banker, will replace Justin Trudeau as Canada’s Liberal Party leader and the country’s prime minister. The party chose him to take on President Trump amid a generational crisis in Canada’s relationship with the U.S. www.nytimes.com/2025/03/09/w...
March 9, 2025 at 10:56 PM
Breaking News: Mark Carney, a banker, will replace Justin Trudeau as Canada’s Liberal Party leader and the country’s prime minister. The party chose him to take on President Trump amid a generational crisis in Canada’s relationship with the U.S. www.nytimes.com/2025/03/09/w...
Understanding the real costs of research
Facilities and Administrative (F&A) Costs Explainer
YouTube video by Association of American Universities
youtu.be
March 7, 2025 at 10:24 PM
Understanding the real costs of research
Reposted by Doug Epstein
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
February 26, 2025 at 1:35 AM
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Reposted by Doug Epstein
Happy International Cochlear Implant Day! Over the years we’ve shared so so many stories from families and individuals who are able to benefit from this life-changing technology (which we helped fund in the 1970s and '80s)! Cheers to these miracle ears! #cochlearimplants #keeplistening
February 25, 2025 at 2:35 PM
Happy International Cochlear Implant Day! Over the years we’ve shared so so many stories from families and individuals who are able to benefit from this life-changing technology (which we helped fund in the 1970s and '80s)! Cheers to these miracle ears! #cochlearimplants #keeplistening
Reposted by Doug Epstein
We did it. Fly Eagles Fly🦅🦅🦅
SUPER BOWL CHAMPIONS!
THIS ONE’S FOR YOU PHILLY!
THIS ONE’S FOR YOU PHILLY!
February 10, 2025 at 3:52 AM
We did it. Fly Eagles Fly🦅🦅🦅
Reposted by Doug Epstein
"Pioneering gene therapy offers hope for restoring hearing in patients with genetic hearing loss. With 155 genes linked to hearing loss and new discoveries every day, navigating this complex genetic landscape presents a monumental challenge.” From: hearinghealthmatters.org/hearing-news...
Ear Science Institute Australia Leads Biobank Initiative to Advance Genetic Therapies and Personalized Treatment for Hearing Loss | Hearing Health & Technology Matters
Ear Science Institute Australia will develop a WA-headquartered Australasian first biobank to advance genetic therapies for childhood and adult hearing loss. The Australasian Hearing Registry and Biob...
hearinghealthmatters.org
January 16, 2025 at 9:55 PM
"Pioneering gene therapy offers hope for restoring hearing in patients with genetic hearing loss. With 155 genes linked to hearing loss and new discoveries every day, navigating this complex genetic landscape presents a monumental challenge.” From: hearinghealthmatters.org/hearing-news...
Reposted by Doug Epstein
Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S
Casey Brown Lecture Series - YouTube
shorturl.at
January 4, 2025 at 2:54 PM
Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S
Reposted by Doug Epstein
New paper alert! @cambupenn G&E student @ngaboreden in the @blobellab on: LDB1 establishes multi-enhancer networks to regulate gene expression
LDB1 establishes multi-enhancer networks to regulate gene expression - PubMed
How specific enhancer-promoter pairing is established remains mostly unclear. Besides the CTCF/cohesin machinery, few nuclear factors have been studied for a direct role in physically connecting…
buff.ly
January 2, 2025 at 8:51 PM
New paper alert! @cambupenn G&E student @ngaboreden in the @blobellab on: LDB1 establishes multi-enhancer networks to regulate gene expression
Reposted by Doug Epstein
How can some vertebrates naturally recover from deafness?
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
December 13, 2024 at 4:58 PM
How can some vertebrates naturally recover from deafness?
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...
Reposted by Doug Epstein
December 6, 2024 at 4:58 PM
Reposted by Doug Epstein
medical scientist training program (MSTP)
December 3, 2024 at 3:32 AM
medical scientist training program (MSTP)
Reposted by Doug Epstein
Following a suggestion from @benecal.bsky.social I will refer to these threads as "skeetorials" and will use this gif logo.
Today's skeetorial is about the NIH Director's New Innovator Award with three different heroes (all in government).
1/n
Today's skeetorial is about the NIH Director's New Innovator Award with three different heroes (all in government).
1/n
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
November 23, 2024 at 1:05 PM
Following a suggestion from @benecal.bsky.social I will refer to these threads as "skeetorials" and will use this gif logo.
Today's skeetorial is about the NIH Director's New Innovator Award with three different heroes (all in government).
1/n
Today's skeetorial is about the NIH Director's New Innovator Award with three different heroes (all in government).
1/n
Our study with @ericjoyce.bsky.social led by Jailynn Harke is out. We show that allelic configurations at the Shh locus are predominately compact in the mouse forebrain, and that long range E-P interactions rely on transcription dependent and independent mechanisms. www.cell.com/molecular-ce...
Multiple allelic configurations govern long-range Shh enhancer-promoter communication in the embryonic forebrain
Harke et al. use sequential DNA-FISH to achieve single-allele resolution of the Sonic
hedgehog (Shh) regulatory domain in the mouse forebrain. They show that multiple allelic
configurations occur inde...
www.cell.com
November 22, 2024 at 4:36 PM
Our study with @ericjoyce.bsky.social led by Jailynn Harke is out. We show that allelic configurations at the Shh locus are predominately compact in the mouse forebrain, and that long range E-P interactions rely on transcription dependent and independent mechanisms. www.cell.com/molecular-ce...