Elise Bornet
@elisebor.bsky.social
Microbiology/ science / and other hobbies 🦜🌸🍺🐶🧬
Westermann Lab
Westermann Lab
Reposted by Elise Bornet
New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848
doi.org/10.1101/2025.09.08.672848
An RNA regulates iron homeostasis and host mucus colonization in Bacteroides thetaiotaomicron
Symbiotic bacteria in the human intestinal microbiota provide many pivotal functions to human health and occupy distinct biogeographic niches within the gut. Yet the molecular basis underlying niche-s...
doi.org
September 9, 2025 at 7:49 AM
New preprint from the lab, in collaboration with Wenhan Zhu (U Vanderbilt): using dual RNA-seq during B. theta colonization of the host mucous layer, we identify IroR--an iron-response sRNA that tunes capsule expression and facilitates adaptation to iron limitation.
doi.org/10.1101/2025.09.08.672848
doi.org/10.1101/2025.09.08.672848
Second that !!!! Super excited and honoured to see this work on Bactetoides morphotypes spotlighted by Qinnan Yang and Eric Martens in Trends in Microbiology.
Very honored that our recent study on Bacteroides morphotypes was spotlighted 🔦 in Trends in Microbiology by Eric Martens & Qinnan Yang: www.cell.com/trends/micro....
Low biomass bacterial transcriptomics takes shape
Bornet et al. apply a low-input bacterial RNA-seq pipeline to transcriptionally profile
small, medium, and large cell populations of the human gut symbiont Bacteroides thetaiotaomicron
separated by fl...
www.cell.com
July 14, 2025 at 12:57 PM
Second that !!!! Super excited and honoured to see this work on Bactetoides morphotypes spotlighted by Qinnan Yang and Eric Martens in Trends in Microbiology.
Reposted by Elise Bornet
Congrats to Gianluca Prezza (@gprezza.bsky.social) for reveiving the 2025 PhD Award from the Friends of the Helmholtz Centre for Infection Research (HZI)!👏 The award honours excellent PhD theses from the field of life sciences at HZI partner universities. His thesis focused Bacteroides' RNA biology.
Beim gestrigen Festakt wurden zudem die HZI-Promotionspreise an Wenchao Li @ciim-hannover.bsky.social und @gprezza.bsky.social aus der Gruppe von @westermannlab.bsky.social @helmholtz-hiri.bsky.social verliehen. Wir gratulieren den beiden zu ihren ausgezeichneten Doktorarbeiten!
July 11, 2025 at 9:35 AM
Congrats to Gianluca Prezza (@gprezza.bsky.social) for reveiving the 2025 PhD Award from the Friends of the Helmholtz Centre for Infection Research (HZI)!👏 The award honours excellent PhD theses from the field of life sciences at HZI partner universities. His thesis focused Bacteroides' RNA biology.
Reposted by Elise Bornet
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Bornet et al. investigate the morphological heterogeneity of Bacteroides thetaiotaomicron cells observed both in laboratory culture and inside the mammalian GI tract. The authors show that cell size is only partially dictated by cell-cycle progression and is associated with distinct gene expression programs that suggest metabolic differentiation.
dlvr.it
June 22, 2025 at 7:51 PM
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Reposted by Elise Bornet
Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Bornet et al. investigate the morphological heterogeneity of Bacteroides thetaiotaomicron
cells observed both in laboratory culture and inside the mammalian GI tract. The authors
show that cell size i...
www.cell.com
June 17, 2025 at 7:11 PM
Our latest: www.cell.com/cell-reports/fulltext/S2211-1247(25)00615-1. Links Bacteroides cell size w/ gene expression. Protocol works even for single cells. 🦠
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Shoutout to @elisebor.bsky.social, @emmanuel-saliba.bsky.social, @lbarquist.bsky.social, @jorg-vogel-lab.bsky.social, Till Strowig & KC Huang.
Excited to share my PhD work!
We used a low-input RNA-seq protocol to dig into what drives cell shape differences in Bacteroides thetaiotaomicron.
Congrats and big thanks to all co-authors 🧫🧬.
We used a low-input RNA-seq protocol to dig into what drives cell shape differences in Bacteroides thetaiotaomicron.
Congrats and big thanks to all co-authors 🧫🧬.
The study was published in the journal @cp-cellreports.bsky.social: www.sciencedirect.com/science/arti...
Low-input RNA-seq suggests metabolic specialization underlying morphological heterogeneity in a gut commensal bacterium
Isogenic bacteria can be phenotypically diverse. This heterogeneity is evident in the Bacteroidota, a predominant phylum of the human gut microbiota. …
www.sciencedirect.com
June 17, 2025 at 4:10 PM
Excited to share my PhD work!
We used a low-input RNA-seq protocol to dig into what drives cell shape differences in Bacteroides thetaiotaomicron.
Congrats and big thanks to all co-authors 🧫🧬.
We used a low-input RNA-seq protocol to dig into what drives cell shape differences in Bacteroides thetaiotaomicron.
Congrats and big thanks to all co-authors 🧫🧬.
Reposted by Elise Bornet
📣Fully funded PhD position available in our lab at @uniwuerzburg.bsky.social, in collaboration with Dr. Connolly at Newcastle University (@ruamicro.bsky.social). "Dissecting the RNA-centric landscape of microbiota-pathogen interactions in the gut”. 🦠
Apply here: www.uni-wuerzburg.de/karriere/sin...
Apply here: www.uni-wuerzburg.de/karriere/sin...
PhD student position at the Chair for Microbiology
www.uni-wuerzburg.de
February 14, 2025 at 8:25 AM
📣Fully funded PhD position available in our lab at @uniwuerzburg.bsky.social, in collaboration with Dr. Connolly at Newcastle University (@ruamicro.bsky.social). "Dissecting the RNA-centric landscape of microbiota-pathogen interactions in the gut”. 🦠
Apply here: www.uni-wuerzburg.de/karriere/sin...
Apply here: www.uni-wuerzburg.de/karriere/sin...
Reposted by Elise Bornet
Interested in collecting, sharing, and interacting with large collections of bacterial functional genomics data (RNA-seq, Tn-seq/TraDIS, etc.)? Check out our new web platform, Micromix, with case studies for Salmonella and Bacteroides! 🧫🧬🖥️🧪 Thread 1/n
academic.oup.com/gigascience/...
academic.oup.com/gigascience/...
Micromix: web infrastructure for visualizing and remixing microbial ‘omics data
Abstract. Micromix is a flexible web platform for sharing and integrating microbial omics data, including RNA sequencing and transposon-insertion sequencin
academic.oup.com
February 4, 2025 at 8:22 PM
Interested in collecting, sharing, and interacting with large collections of bacterial functional genomics data (RNA-seq, Tn-seq/TraDIS, etc.)? Check out our new web platform, Micromix, with case studies for Salmonella and Bacteroides! 🧫🧬🖥️🧪 Thread 1/n
academic.oup.com/gigascience/...
academic.oup.com/gigascience/...
Reposted by Elise Bornet
Is it anything Hfq-like (RNA chaperone)? Or similar to CsrA (global translation modulator)? We don't know yet. But as it stands, Bacteroidota RRM proteins appear as excellent candidates to map post-transcriptional networks in a substantial fraction of the microbiota. www.nature.com/articles/s41...
January 9, 2025 at 9:33 AM
Is it anything Hfq-like (RNA chaperone)? Or similar to CsrA (global translation modulator)? We don't know yet. But as it stands, Bacteroidota RRM proteins appear as excellent candidates to map post-transcriptional networks in a substantial fraction of the microbiota. www.nature.com/articles/s41...