Dave Weisman
@dweisman.bsky.social
Neurologist, trialist, focused on Alzheimer’s disease.
Skeptical doesn’t mean cynical.
Skeptical doesn’t mean cynical.
Earned that poutine.
October 25, 2025 at 11:41 PM
Earned that poutine.
I love Canada. Got to speak at the CAGP-CCSMH 2025 Annual Scientific Meeting.
October 25, 2025 at 9:53 PM
I love Canada. Got to speak at the CAGP-CCSMH 2025 Annual Scientific Meeting.
Wrapping up Vermont riding.
September 25, 2025 at 1:00 AM
Wrapping up Vermont riding.
Another mouseheimer's paper blown up beyond all reason. Please, do not take Lithium for memory or Alzheimer's disease.
wapo.st/47uJMrU
wapo.st/47uJMrU
How lithium went from 7Up to treatment for mental illness — and maybe Alzheimer’s
A new study suggests lithium may play a crucial role in developing Alzheimer’s treatments, but the substance has long been used to treat mood disorders like bipolar disorder.
wapo.st
August 11, 2025 at 2:35 PM
Another mouseheimer's paper blown up beyond all reason. Please, do not take Lithium for memory or Alzheimer's disease.
wapo.st/47uJMrU
wapo.st/47uJMrU
The basis of informed consent is falsifying medical records?
July 15, 2025 at 5:00 PM
The basis of informed consent is falsifying medical records?
How to implement anti-amyloid therapies lecanemab or donanemab:
practicalneurology.com/diseases-dia...
practicalneurology.com/diseases-dia...
Building an Infrastructure to Administer Amyloid-Targeting Treatments
With the introduction of amyloid-targeting therapies, clinicians face a paradigm shift, requiring new clinical systems, interdisciplinary teams, and exper…
practicalneurology.com
July 11, 2025 at 12:41 PM
How to implement anti-amyloid therapies lecanemab or donanemab:
practicalneurology.com/diseases-dia...
practicalneurology.com/diseases-dia...
New titration of donanemab is approved. Not aware of anyone who use the previous titration, but good to see this.
www.biospace.com/policy/lilly...
www.biospace.com/policy/lilly...
Lilly Gets FDA Label Update for Alzheimer’s Drug To Mitigate Safety Concerns
The FDA will allow a new dosing schedule for Eli Lilly’s Alzheimer’s drug Kisunla that could lessen a known side effect of the monoclonal antibody drug class that has led to several deaths.
www.biospace.com
July 11, 2025 at 11:11 AM
New titration of donanemab is approved. Not aware of anyone who use the previous titration, but good to see this.
www.biospace.com/policy/lilly...
www.biospace.com/policy/lilly...
This entire Sage story added nothing to patient care or to the economy. Just wasted efforts to rearrange the deck chairs. Then set all the staff adrift.
www.biospace.com/business/sag...
www.biospace.com/business/sag...
Sage’s Search for Lifeline Ran Into Defiant Biogen CEO
After the FDA rejection of Zurzuvae in one type of depression and the triple failure of neuro asset dalzanemdor, Sage was searching for a path forward at the end of December 2024. Biogen CEO Chris Vie...
www.biospace.com
July 4, 2025 at 10:48 PM
This entire Sage story added nothing to patient care or to the economy. Just wasted efforts to rearrange the deck chairs. Then set all the staff adrift.
www.biospace.com/business/sag...
www.biospace.com/business/sag...
I did a thing for Medscape. Very good patient-physician interactions, and the structure and thinking behind those conversations.
www.medscape.org/sites/pwr/ad...
www.medscape.org/sites/pwr/ad...
Life in the Dementia Clinic: Contextualizing Treatment Options for Early Stages of Alzheimer's Disease
Unlock Better Conversations: Guiding Patients Through Benefits and Risks of Anti-Amyloid Alzheimer's Therapy
www.medscape.org
June 28, 2025 at 3:00 PM
I did a thing for Medscape. Very good patient-physician interactions, and the structure and thinking behind those conversations.
www.medscape.org/sites/pwr/ad...
www.medscape.org/sites/pwr/ad...
How many humans will die as a result of this? Pathogens don't respect borders.
www.nytimes.com/2025/06/25/h...
www.nytimes.com/2025/06/25/h...
Kennedy Withdraws Funding Pledge to International Vaccine Agency
www.nytimes.com
June 25, 2025 at 3:19 PM
How many humans will die as a result of this? Pathogens don't respect borders.
www.nytimes.com/2025/06/25/h...
www.nytimes.com/2025/06/25/h...
Can the UK legislate itself to biotech greatness? At least they're trying.
www.fiercepharma.com/pharma/uk-la...
www.fiercepharma.com/pharma/uk-la...
UK lays out strategy to become a top 3 life sciences economy by 2035
With a goal of boosting its life sciences economy into the top three of the global rankings by 2035, the U.K. | With a goal of boosting its life sciences economy into the top three of the global ranki...
www.fiercepharma.com
June 25, 2025 at 11:24 AM
Can the UK legislate itself to biotech greatness? At least they're trying.
www.fiercepharma.com/pharma/uk-la...
www.fiercepharma.com/pharma/uk-la...
Incrementalism works. This is great news. www.nytimes.com/2025/06/03/h...
From No Hope to a Potential Cure for a Deadly Blood Cancer
www.nytimes.com
June 5, 2025 at 9:02 PM
Incrementalism works. This is great news. www.nytimes.com/2025/06/03/h...
This comes up all the time. Great idea, I hope this is implemented widely.
Know anyone diagnosed with Alzheimer's? So challenging for him/her & the family. @alzassociation.bsky.social just put out this great app for these folks- to connect them w/resources & to help them navigate this hard time. Please spread the word about this app. #endalz
www.alz.org/news/2025/mo...
www.alz.org/news/2025/mo...
Alzheimer’s Association Launches Free Mobile App to Support Newly Diagnosed Individuals and Care Partners
My ALZ Journey offers early-stage individuals and their care partners personalized guidance, tools, and local resources to navigate Alzheimer's and dementia.
www.alz.org
May 28, 2025 at 11:26 PM
This comes up all the time. Great idea, I hope this is implemented widely.
"Unless these journals change dramatically, we are going to stop NIH scientists from publishing there, and we're going to create our own journals... They're going to become the pre-eminent journals, because if you get NIH funding, it is anointing you as a good, legitimate scientist." -K Jr.
What?
What?
May 28, 2025 at 11:20 PM
"Unless these journals change dramatically, we are going to stop NIH scientists from publishing there, and we're going to create our own journals... They're going to become the pre-eminent journals, because if you get NIH funding, it is anointing you as a good, legitimate scientist." -K Jr.
What?
What?
Excellent takedown of an Alzheimer’s quack.
My only critique of the piece is that we need more photos of that cat.
Great job @nytimes.com - almost making up for the APOE article.
www.nytimes.com/2025/05/21/w...
My only critique of the piece is that we need more photos of that cat.
Great job @nytimes.com - almost making up for the APOE article.
www.nytimes.com/2025/05/21/w...
An Expensive Alzheimer’s Lifestyle Plan Offers False Hope, Experts Say
www.nytimes.com
May 22, 2025 at 4:32 PM
Excellent takedown of an Alzheimer’s quack.
My only critique of the piece is that we need more photos of that cat.
Great job @nytimes.com - almost making up for the APOE article.
www.nytimes.com/2025/05/21/w...
My only critique of the piece is that we need more photos of that cat.
Great job @nytimes.com - almost making up for the APOE article.
www.nytimes.com/2025/05/21/w...
A pediatrician at Feinberg Northwestern just denied an amyloid PET scan on the phone with me. Does this world even make sense anymore?
May 19, 2025 at 9:47 PM
A pediatrician at Feinberg Northwestern just denied an amyloid PET scan on the phone with me. Does this world even make sense anymore?
The Wash U lecanemab paper is a hard act to follow. But here’s a combo experience with a private clinic and U Wash.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Monoclonal antibody administration in an academic institution and private neurological practice: a tale of two clinics - Journal of Neurology
The emergence of monoclonal antibody (MABs) drugs since the FDA approval of lecanemab has resulted in dramatic changes in the clinical approach and management of early-stage Alzheimer’s disease (AD). ...
link.springer.com
May 14, 2025 at 12:03 PM
The Wash U lecanemab paper is a hard act to follow. But here’s a combo experience with a private clinic and U Wash.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Probably the best data since lecanamab RCT and OLE on patient safety. @suzanneeschindler.bsky.social et al did RCT level trial work on every patient getting leqembi with HUGE n, kept things boring, with many lessons learned here.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Lecanemab Treatment in a Specialty Memory Clinic
This study examines the feasibility and safety of treating patients in specialty memory clinics with lecanemab.
jamanetwork.com
May 12, 2025 at 5:40 PM
Probably the best data since lecanamab RCT and OLE on patient safety. @suzanneeschindler.bsky.social et al did RCT level trial work on every patient getting leqembi with HUGE n, kept things boring, with many lessons learned here.
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
I’m up in the mountains of Denver. Trails going up need oxygen.
May 3, 2025 at 12:09 AM
I’m up in the mountains of Denver. Trails going up need oxygen.
New point when doing insurance “peer to peers.”
April 26, 2025 at 5:03 PM
New point when doing insurance “peer to peers.”
