Dominick
@dhellen.bsky.social
PhD, Genetics and Molecular Biology // Postdoc - Griffith Lab - MIT BE
GH: https://github.com/DominickHellen
GH: https://github.com/DominickHellen
Reposted by Dominick
Preprint out now (@graczlab.bsky.social): doi.org/10.1101/2025...
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
Quantitative 3D imaging of mouse and human intrahepatic bile ducts in homeostasis and liver injury
Intrahepatic bile ducts (IHBDs) form a complex hierarchical network essential for liver function. Remodeling and expansion of this network during ductular reaction (DR) is a hallmark of liver disease ...
doi.org
April 25, 2025 at 9:43 PM
Preprint out now (@graczlab.bsky.social): doi.org/10.1101/2025...
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8
Reposted by Dominick
Nature research paper: Multi-zonal liver organoids from human pluripotent stem cells
https://go.nature.com/3G7Pepk
https://go.nature.com/3G7Pepk
Multi-zonal liver organoids from human pluripotent stem cells - Nature
Liver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for transplantation in animal models of liver dysfunction.
go.nature.com
April 17, 2025 at 2:24 PM
Nature research paper: Multi-zonal liver organoids from human pluripotent stem cells
https://go.nature.com/3G7Pepk
https://go.nature.com/3G7Pepk
Reposted by Dominick
Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems https://www.biorxiv.org/content/10.1101/2025.01.17.633624v1
January 22, 2025 at 4:06 PM
Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems https://www.biorxiv.org/content/10.1101/2025.01.17.633624v1
Reposted by Dominick
Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
March 6, 2025 at 10:52 PM
Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Dominick
We are crowd sourcing reductions in graduate admissions and hiring freezes across biomedical research and higher ed in response to pauses in NIH funding and EO’s. If you have information if you could add to this spreadsheet, it would be greatly appreciated!: docs.google.com/spreadsheets...
Graduate Reductions Across Biomedical Sciences (2025)
docs.google.com
February 22, 2025 at 6:09 PM
We are crowd sourcing reductions in graduate admissions and hiring freezes across biomedical research and higher ed in response to pauses in NIH funding and EO’s. If you have information if you could add to this spreadsheet, it would be greatly appreciated!: docs.google.com/spreadsheets...
Reposted by Dominick
Some good news: @hannahhrncir.bsky.social ‘s primary PhD paper is finally online! This study lays the groundwork for a lot of technical and conceptual things the lab is currently working on, including light sheet microscopy for imaging entire biliary trees in mouse liver: rdcu.be/d90Br 1/4
Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis
Nature Communications - The bile ducts of the liver form a network of large ducts and small ductules, though how they are patterned remains unclear. Hrncir et al. show that Sox9 is required for the...
rdcu.be
February 16, 2025 at 7:30 PM
Some good news: @hannahhrncir.bsky.social ‘s primary PhD paper is finally online! This study lays the groundwork for a lot of technical and conceptual things the lab is currently working on, including light sheet microscopy for imaging entire biliary trees in mouse liver: rdcu.be/d90Br 1/4
Reposted by Dominick
A Microphysiological Model of Progressive Human Hepatic Insulin Resistance https://www.biorxiv.org/content/10.1101/2025.01.08.631261v1
January 8, 2025 at 10:46 PM
A Microphysiological Model of Progressive Human Hepatic Insulin Resistance https://www.biorxiv.org/content/10.1101/2025.01.08.631261v1