Dewson Lab
@dewsonlab.bsky.social
Studying the mighty mitochondria and their impact on life, death, and everything in between.
Reposted by Dewson Lab
Great to welcome prospective Honours, Masters and PhD students to WEHI’s 2025 Student Open Day.
Attendees heard from staff and students, explored our laboratories, discussed research projects with supervisors and connected with peers. 🧪🔬
💻 More info: www.wehi.edu.au/education/st...
Attendees heard from staff and students, explored our laboratories, discussed research projects with supervisors and connected with peers. 🧪🔬
💻 More info: www.wehi.edu.au/education/st...
September 5, 2025 at 7:02 AM
Great to welcome prospective Honours, Masters and PhD students to WEHI’s 2025 Student Open Day.
Attendees heard from staff and students, explored our laboratories, discussed research projects with supervisors and connected with peers. 🧪🔬
💻 More info: www.wehi.edu.au/education/st...
Attendees heard from staff and students, explored our laboratories, discussed research projects with supervisors and connected with peers. 🧪🔬
💻 More info: www.wehi.edu.au/education/st...
Reposted by Dewson Lab
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.
🔗 www.wehi.edu.au/news/eureka-...
🔗 www.wehi.edu.au/news/eureka-...
September 3, 2025 at 9:54 PM
Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works.
🔗 www.wehi.edu.au/news/eureka-...
🔗 www.wehi.edu.au/news/eureka-...
Join us for Prof. Michele Callisaya's talk on how ParkinsonsNet is going to improve access to high quality Parkinsons care in Australia. teams.microsoft.com/l/meetup-joi...
July 23, 2025 at 5:27 AM
Join us for Prof. Michele Callisaya's talk on how ParkinsonsNet is going to improve access to high quality Parkinsons care in Australia. teams.microsoft.com/l/meetup-joi...
Reposted by Dewson Lab
Final version of our paper on targeting BAK / BAX to modulate apoptosis is out✌️! Can't wait to see where these tool compounds can be used💊. Honour to work in this team with screening scientists, chemists, biologists & more @dcshuang.bsky.social @dewsonlab.bsky.social @wehi-research.bsky.social
www.science.org/doi/10.1126/...
Our new paper out now by Kaiming Li using a tool compound that highlights the coordination of BAX and BAK apoptotic activity through interaction with VDAC2 that may be targeted therapeutically.
Our new paper out now by Kaiming Li using a tool compound that highlights the coordination of BAX and BAK apoptotic activity through interaction with VDAC2 that may be targeted therapeutically.
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
Opposing regulation of BAX and BAK by VDAC2 dictates their role as executioners of apoptosis and their therapeutic targeting.
www.science.org
March 29, 2025 at 9:10 AM
Final version of our paper on targeting BAK / BAX to modulate apoptosis is out✌️! Can't wait to see where these tool compounds can be used💊. Honour to work in this team with screening scientists, chemists, biologists & more @dcshuang.bsky.social @dewsonlab.bsky.social @wehi-research.bsky.social
Reposted by Dewson Lab
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
Reposted by Dewson Lab
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
www.wehi.edu.au/news/scienti...
www.wehi.edu.au/news/scienti...
Scientists solve decades-long Parkinson’s mystery
WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.
www.wehi.edu.au
March 13, 2025 at 9:58 PM
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
www.wehi.edu.au/news/scienti...
www.wehi.edu.au/news/scienti...
www.science.org/doi/10.1126/...
Our new paper out now by Kaiming Li using a tool compound that highlights the coordination of BAX and BAK apoptotic activity through interaction with VDAC2 that may be targeted therapeutically.
Our new paper out now by Kaiming Li using a tool compound that highlights the coordination of BAX and BAK apoptotic activity through interaction with VDAC2 that may be targeted therapeutically.
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules
Opposing regulation of BAX and BAK by VDAC2 dictates their role as executioners of apoptosis and their therapeutic targeting.
www.science.org
March 9, 2025 at 6:51 AM
www.science.org/doi/10.1126/...
Our new paper out now by Kaiming Li using a tool compound that highlights the coordination of BAX and BAK apoptotic activity through interaction with VDAC2 that may be targeted therapeutically.
Our new paper out now by Kaiming Li using a tool compound that highlights the coordination of BAX and BAK apoptotic activity through interaction with VDAC2 that may be targeted therapeutically.
Reposted by Dewson Lab
Session 11: Sylvie Callegari -Structure of human PINK1 stabilised at a novel mitochondrial translocase. Sense mito damage, stabilised on TOM complex, activate ub kinase activity, ub phosphorylation. 100 kDa band disulphide to PINK1 Cys40 with peroxide treatment? #LorneProteins2025
February 12, 2025 at 5:57 AM
Session 11: Sylvie Callegari -Structure of human PINK1 stabilised at a novel mitochondrial translocase. Sense mito damage, stabilised on TOM complex, activate ub kinase activity, ub phosphorylation. 100 kDa band disulphide to PINK1 Cys40 with peroxide treatment? #LorneProteins2025